Detail Information

Basic Information:


  VIRBase ID:  

HHID00070662

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1274a GMFB
miRBase
Accession/Entrez ID		 MIMAT0005927 2764
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - GMF

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR GMFB
chr14:54954141(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GMFB
chr14:54942712-54942713(-) m6A 3'UTR       27773535
chr14:54944747-54944748(-) m6A 3'UTR//exon       27773535
chr14:54944799-54944800(-) m6A 3'UTR//exon       27773535
chr14:54944823-54944824(-) m6A 3'UTR//CDS//exon       27773535
chr14:54944851-54944852(-) m6A 3'UTR//CDS//exon       27773535
chr14:54946512-54946513(-) m6A 3'UTR//CDS//exon       27773535
chr14:54946520-54946521(-) m6A 3'UTR//CDS//exon       27773535
chr14:54946563-54946564(-) m6A 3'UTR//CDS//exon       27773535
chr14:54950405-54950406(-) m6A CDS//exon       24209618//24981863//27773535
chr14:54950684-54950685(-) m6A CDS//intron       24209618//24981863
chr14:54950736-54950737(-) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate GMFB
Exosome Blood     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1274a
Eloxatine 5310940 Drug interaction    RC00007819
Epirubicin 41867 Drug interaction    RC00007817
Paclitaxel 36314 Drug interaction    RC00007816
Sorafenib 216239 Drug interaction    RC00007818
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1274a
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Nvp-aew541       11476171

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1274a
Interactor2: GMFB

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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