Basic Information:

  VIRBase ID:  

HHID00070560

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548o-3p:  MIMAT0005919          CPSF6:  NM_007007     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548o-3p	CPSF6
miRBase Accession/Entrez ID	MIMAT0005919	11052
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CFIM//CFIM68//CFIM72//HPBRII-4//HPBRII-7

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548o-3p	rs1339101861 chr20:38516618    G/T rs1456728168 chr20:38516617    A/G rs1273591644 chr7:102405749    C/T rs1307755111 chr7:102405760    G/C rs1351519463 chr7:102405754    G/A rs922259473 chr7:102405753    A/G rs1429904758 chr20:38516608    CA/C rs901320936 chr20:38516614    T/C rs1408359821 chr7:102405766    T/C rs1554571744 chr7:102405762    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CPSF6	chr12:69648917(+) A-I      intronic chr12:69648967(+) A-I      intronic chr12:69648925(+) A-I      intronic chr12:69648921(+) A-I      intronic chr12:69649886(+) A-I      intronic chr12:69639778(+) A-I      intronic chr12:69639746(+) A-I      intronic chr12:69648966(+) A-I      intronic chr12:69639588(+) A-I      intronic chr12:69648952(+) A-I      intronic chr12:69639808(+) A-I      intronic chr12:69639619(+) A-I      intronic chr12:69637713(+) A-I      intronic chr12:69640704(+) A-I      intronic chr12:69637717(+) A-I      intronic chr12:69637738(+) A-I      intronic chr12:69639688(+) A-I      intronic chr12:69637759(+) A-I      intronic chr12:69644488(+) A-I      intronic chr12:69639728(+) A-I      intronic chr12:69639634(+) A-I      intronic chr12:69639724(+) A-I      intronic chr12:69639787(+) A-I      intronic chr12:69644688(+) A-I      intronic chr12:69644662(+) A-I      intronic chr12:69644526(+) A-I      intronic chr12:69644556(+) A-I      intronic chr12:69644483(+) A-I      intronic chr12:69644501(+) A-I      intronic chr12:69640706(+) A-I      intronic chr12:69644520(+) A-I      intronic chr12:69639715(+) A-I      intronic chr12:69636634(+) A-I      intronic chr12:69637707(+) A-I      intronic chr12:69637743(+) A-I      intronic chr12:69636633(+) A-I      intronic chr12:69654614(+) A-I      intronic chr12:69639761(+) A-I      intronic chr12:69644700(+) A-I      intronic chr12:69639733(+) A-I      intronic chr12:69651595(+) A-I      NonSyn:Arg->Gly chr12:69639709(+) A-I      intronic chr12:69638806(+) A-I      intronic chr12:69640608(+) A-I      intronic chr12:69639720(+) A-I      intronic chr12:69644544(+) A-I      intronic chr12:69636734(+) A-I      intronic chr12:69636767(+) A-I      intronic chr12:69640612(+) A-I      intronic chr12:69642772(+) A-I      intronic chr12:69639608(+) A-I      intronic chr12:69642771(+) A-I      intronic chr12:69655325(+) A-I      intronic chr12:69639646(+) A-I      intronic chr12:69637714(+) A-I      intronic chr12:69638066(+) A-I      intronic chr12:69649922(+) A-I      intronic chr12:69650026(+) A-I      intronic chr12:69638828(+) A-I      intronic chr12:69639740(+) A-I      intronic chr12:69650006(+) A-I      intronic chr12:69636807(+) A-I      intronic chr12:69639707(+) A-I      intronic chr12:69639822(+) A-I      intronic chr12:69654689(+) A-I      intronic chr12:69639843(+) A-I      intronic chr12:69639788(+) A-I      intronic chr12:69648821(+) A-I      intronic chr12:69648916(+) A-I      intronic chr12:69649919(+) A-I      intronic chr12:69649882(+) A-I      intronic chr12:69636768(+) A-I      intronic chr12:69639708(+) A-I      intronic chr12:69638413(+) A-I      intronic chr12:69649830(+) A-I      intronic chr12:69649007(+) A-I      intronic chr12:69638777(+) A-I      intronic chr12:69650121(+) A-I      intronic chr12:69654673(+) A-I      intronic chr12:69639747(+) A-I      intronic chr12:69654631(+) A-I      intronic chr12:69644616(+) A-I      intronic chr12:69648994(+) A-I      intronic chr12:69649888(+) A-I      intronic chr12:69649760(+) A-I      intronic chr12:69648904(+) A-I      intronic chr12:69649903(+) A-I      intronic chr12:69649832(+) A-I      intronic chr12:69637700(+) A-I      intronic chr12:69649931(+) A-I      intronic chr12:69637753(+) A-I      intronic chr12:69648780(+) A-I      intronic chr12:69649937(+) A-I      intronic chr12:69636746(+) A-I      intronic chr12:69639702(+) A-I      intronic chr12:69649077(+) A-I      intronic chr12:69637816(+) A-I      intronic chr12:69637836(+) A-I      intronic chr12:69644527(+) A-I      intronic chr12:69642853(+) A-I      intronic chr12:69636808(+) A-I      intronic chr12:69639705(+) A-I      intronic chr12:69639756(+) A-I      intronic chr12:69640718(+) A-I      intronic chr12:69649751(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CPSF6	chr12:69648821(+) A-I intron -    21960545   //22327324 chr12:69648916(+) A-I intron -    21960545 chr12:69648966(+) A-I intron -    21960545 chr12:69648994(+) A-I intron -    21960545 chr12:69649007(+) A-I intron -    21960545 chr12:69649077(+) A-I intron -    21960545 chr12:69649832(+) A-I intron -    21960545 chr12:69649882(+) A-I intron -    21960545 chr12:69649886(+) A-I intron -    21960545 chr12:69649888(+) A-I intron -    21960545 chr12:69649931(+) A-I intron -    21960545 chr12:69654689(+) A-I intron -    21960545 chr12:69655127(+) A-I intron -    21960545 chr12:69648821(+) A-G intron -    22484847 chr12:69649751(+) A-G intron -    22484847 chr12:69649830(+) A-G intron -    22484847 chr12:69649832(+) A-G intron -    22484847 chr12:69649882(+) A-G intron -    22484847 chr12:69649919(+) A-G intron -    22484847 chr12:69649931(+) A-G intron -    22484847 chr12:69649937(+) A-G intron -    22484847 chr12:69638777(+) A-G intron -    22484847 chr12:69639646(+) A-G intron -    22484847 chr12:69639702(+) A-G intron -    22484847 chr12:69639708(+) A-G intron -    22484847 chr12:69639740(+) A-G intron -    22484847 chr12:69639747(+) A-G intron -    22484847 chr12:69639756(+) A-G intron -    22484847 chr12:69639788(+) A-G intron -    22484847 chr12:69646049(+) G-A intron -    22484847 chr12:69654673(+) A-G intron -    22484847 chr12:69637816(+) A-G intron -    22484847 chr12:69639720(+) A-G intron -    22484847 chr12:69639733(+) A-G intron -    22484847 chr12:69639761(+) A-G intron -    22484847 chr12:69639822(+) A-G intron -    22484847 chr12:69644520(+) A-G intron -    22484847 chr12:69644527(+) A-G intron -    22484847 chr12:69644544(+) A-G intron -    22484847 chr12:69655325(+) A-G intron -    22484847 chr12:69659507(+) G-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CPSF6	chr12:69633380-69633381(+) m6A 5'UTR       25456834//24981863 chr12:69633442-69633443(+) m6A CDS//exon       24981863//22575960 chr12:69633451-69633452(+) m6A CDS//exon       24981863//22575960 chr12:69644993-69644994(+) m6A CDS//exon//intron       - chr12:69652373-69652374(+) m6A CDS//intron       24284625 chr12:69652517-69652518(+) m6A CDS//intron       24284625//24981863 chr12:69652619-69652620(+) m6A CDS//intron       24284625//24981863 chr12:69652709-69652710(+) m6A CDS//intron       24284625//24981863//22575960 chr12:69652747-69652748(+) m6A CDS//intron       24284625//24981863//22575960 chr12:69653875-69653876(+) m6A CDS//intron       27773535 chr12:69656175-69656176(+) m6A CDS//intron       24981863//27773535 chr12:69656190-69656191(+) Gm CDS//intron       - chr12:69656226-69656227(+) m6A CDS//intron       24981863//27773535 chr12:69656292-69656293(+) m6A CDS       24981863//26404942//27773535//22575960//22608085 chr12:69663317-69663318(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr12:69663322-69663323(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr12:69663378-69663379(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr12:69663383-69663384(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr12:69663410-69663411(+) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22608085 chr12:69663505-69663506(+) m6A 3'UTR       24981863//22608085 chr12:69663664-69663665(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548o-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	CPSF6	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548o-3p
Interactor2: CPSF6

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.