Basic Information:

  VIRBase ID:  

HHID00070526

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548n:  MIMAT0005916          C18orf54:  NM_001288980     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548n	C18orf54
miRBase Accession/Entrez ID	MIMAT0005916	162681
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LAS2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548n	rs1167799411 chr7:34940804    A/G rs1349024540 chr7:34940825    G/C rs1440338026 chr7:34940814    C/G rs1440338026 chr7:34940814    C/T rs1014154255 chr7:34940819    A/G rs1170899735 chr7:34940820    C/T rs541369935 chr7:34940820    CT/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C18orf54	chr18:51885024-51885025(+) m6A 5'UTR//intron       25456834 chr18:51886921-51886922(+) m6A 5'UTR//intron       24981863 chr18:51886957-51886958(+) m6A CDS//intron       24981863 chr18:51886962-51886963(+) m6A CDS//intron       24981863 chr18:51886968-51886969(+) m6A CDS//intron       24981863 chr18:51887214-51887215(+) m6A CDS//intron       24981863//22608085 chr18:51887219-51887220(+) m6A CDS//intron       24981863//22608085 chr18:51888021-51888022(+) m6A CDS//intron       24981863//22608085 chr18:51888045-51888046(+) m6A CDS//intron       24284625//24981863//22608085 chr18:51888064-51888065(+) m6A CDS//intron       24284625//24981863//22608085 chr18:51888084-51888085(+) m6A CDS//intron       24284625//24981863//22608085 chr18:51888118-51888119(+) m6A CDS//intron       24284625//24981863//22608085 chr18:51888157-51888158(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:51888183-51888184(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:51888202-51888203(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:51888216-51888217(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr18:51888244-51888245(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr18:51888330-51888331(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr18:51888337-51888338(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr18:51888350-51888351(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr18:51888408-51888409(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr18:51888418-51888419(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr18:51888534-51888535(+) m6A CDS//intron       24981863//22608085 chr18:51888601-51888602(+) m6A CDS//intron       24981863//22608085 chr18:51888623-51888624(+) m6A CDS//intron       24981863//22608085 chr18:51888670-51888671(+) m6A CDS//intron       22608085 chr18:51888678-51888679(+) m6A CDS//intron       22608085 chr18:51898937-51898938(+) m6A CDS//exon       - chr18:51898963-51898964(+) m6A CDS//exon       - chr18:51904572-51904573(+) m6A CDS//exon       24981863//27773535//22608085 chr18:51904629-51904630(+) m6A 3'UTR       24981863//27773535//22608085 chr18:51904659-51904660(+) m6A 3'UTR       24981863//27773535//22608085 chr18:51904687-51904688(+) m6A 3'UTR       24209618//24981863//27773535//22575960//22608085 chr18:51904752-51904753(+) m6A 3'UTR//intron       24284625//24209618//24981863//22575960//22608085 chr18:51904759-51904760(+) m6A 3'UTR//intron       24284625//24209618//24981863//22575960//22608085 chr18:51904785-51904786(+) m6A 3'UTR//intron       24284625//24209618//24981863//22575960//22608085 chr18:51904822-51904823(+) m6A 3'UTR//intron       24284625//24209618//24981863//22575960//22608085 chr18:51904831-51904832(+) m6A 3'UTR//intron       24284625//24209618//24981863//22575960//22608085 chr18:51904983-51904984(+) m6A 3'UTR//intron       24981863//22608085 chr18:51905022-51905023(+) m6A 3'UTR//intron       24981863//22608085 chr18:51905056-51905057(+) m6A 3'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548n	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	C18orf54	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548n
Interactor2: C18orf54

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.