Basic Information:

  VIRBase ID:  

HHID00070478

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548n:  MIMAT0005916          ACTR6:  NM_022496     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548n	ACTR6
miRBase Accession/Entrez ID	MIMAT0005916	64431
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARP6//CDA12//hARP6//hARPX//HSPC281//MSTP136

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548n	rs1167799411 chr7:34940804    A/G rs1349024540 chr7:34940825    G/C rs1440338026 chr7:34940814    C/G rs1440338026 chr7:34940814    C/T rs1014154255 chr7:34940819    A/G rs1170899735 chr7:34940820    C/T rs541369935 chr7:34940820    CT/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ACTR6	chr12:100605167(+) A-I      intronic chr12:100604341(+) A-I      intronic chr12:100615993(+) A-I      intronic chr12:100600135(+) A-I      intronic chr12:100604345(+) A-I      intronic chr12:100600906(+) A-I      intronic chr12:100606971(+) A-I      intronic chr12:100604347(+) A-I      intronic chr12:100600162(+) A-I      intronic chr12:100614638(+) A-I      intronic chr12:100614523(+) A-I      intronic chr12:100604370(+) A-I      intronic chr12:100603136(+) A-I      intronic chr12:100600098(+) A-I      intronic chr12:100600125(+) A-I      intronic chr12:100601122(+) A-I      intronic chr12:100600002(+) A-I      intronic chr12:100603156(+) A-I      intronic chr12:100616972(+) A-I      intronic chr12:100616861(+) A-I      intronic chr12:100616860(+) A-I      intronic chr12:100616440(+) A-I      intronic chr12:100617022(+) A-I      intronic chr12:100602807(+) A-I      intronic chr12:100603141(+) A-I      intronic chr12:100617071(+) A-I      intronic chr12:100616383(+) A-I      intronic chr12:100600001(+) A-I      intronic chr12:100615955(+) A-I      intronic chr12:100616298(+) A-I      intronic chr12:100616414(+) A-I      intronic chr12:100602695(+) A-I      intronic chr12:100608462(+) A-I      intronic chr12:100603153(+) A-I      intronic chr12:100610051(+) A-I      intronic chr12:100603219(+) A-I      intronic chr12:100615452(+) A-I      intronic chr12:100604346(+) A-I      intronic chr12:100615453(+) A-I      intronic chr12:100604883(+) A-I      intronic chr12:100602799(+) A-I      intronic chr12:100606691(+) A-I      intronic chr12:100602650(+) A-I      intronic chr12:100614722(+) A-I      intronic chr12:100596474(+) A-I      intronic chr12:100610059(+) A-I      intronic chr12:100608392(+) A-I      intronic chr12:100601086(+) A-I      intronic chr12:100615444(+) A-I      intronic chr12:100600200(+) A-I      intronic chr12:100601087(+) A-I      intronic chr12:100602592(+) A-I      intronic chr12:100602599(+) A-I      intronic chr12:100614740(+) A-I      intronic chr12:100600527(+) A-I      intronic chr12:100600911(+) A-I      intronic chr12:100601095(+) A-I      intronic chr12:100600526(+) A-I      intronic chr12:100602651(+) A-I      intronic chr12:100615474(+) A-I      intronic chr12:100603188(+) A-I      intronic chr12:100615826(+) A-I      intronic chr12:100606596(+) A-I      intronic chr12:100600961(+) A-I      intronic chr12:100615833(+) A-I      intronic chr12:100600939(+) A-I      intronic chr12:100608406(+) A-I      intronic chr12:100596590(+) A-I      intronic chr12:100596514(+) A-I      intronic chr12:100615954(+) A-I      intronic chr12:100614690(+) A-I      intronic chr12:100596498(+) A-I      intronic chr12:100595820(+) A-I      intronic chr12:100614685(+) A-I      intronic chr12:100615913(+) A-I      intronic chr12:100614654(+) A-I      intronic chr12:100601057(+) A-I      intronic chr12:100614650(+) A-I      intronic chr12:100614618(+) A-I      intronic chr12:100603047(+) A-I      intronic chr12:100615688(+) A-I      intronic chr12:100614574(+) A-I      intronic chr12:100615651(+) A-I      intronic chr12:100596547(+) A-I      intronic chr12:100615953(+) A-I      intronic chr12:100602710(+) A-I      intronic chr12:100603109(+) A-I      intronic chr12:100614534(+) A-I      intronic chr12:100603125(+) A-I      intronic chr12:100603140(+) A-I      intronic chr12:100615498(+) A-I      intronic chr12:100615475(+) A-I      intronic chr12:100602625(+) A-I      intronic chr12:100616270(+) A-I      intronic chr12:100616297(+) A-I      intronic chr12:100600958(+) A-I      intronic chr12:100596563(+) A-I      intronic chr12:100600145(+) A-I      intronic chr12:100606582(+) A-I      intronic chr12:100603114(+) A-I      intronic chr12:100602624(+) A-I      intronic chr12:100616439(+) A-I      intronic chr12:100596580(+) A-I      intronic chr12:100616447(+) A-I      intronic chr12:100603056(+) A-I      intronic chr12:100600141(+) A-I      intronic chr12:100600547(+) A-I      intronic chr12:100614671(+) A-I      intronic chr12:100596524(+) A-I      intronic chr12:100596576(+) A-I      intronic chr12:100596544(+) A-I      intronic chr12:100595675(+) A-I      intronic chr12:100603110(+) A-I      intronic chr12:100602708(+) A-I      intronic chr12:100614644(+) A-I      intronic chr12:100603206(+) A-I      intronic chr12:100600965(+) A-I      intronic chr12:100596520(+) A-I      intronic chr12:100595529(+) A-I      intronic chr12:100606948(+) A-I      intronic chr12:100596585(+) A-I      intronic chr12:100603205(+) A-I      intronic chr12:100596473(+) A-I      intronic chr12:100600944(+) A-I      intronic chr12:100614658(+) A-I      intronic chr12:100602543(+) A-I      intronic chr12:100606917(+) A-I      intronic chr12:100602714(+) A-I      intronic chr12:100606900(+) A-I      intronic chr12:100616271(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ACTR6	chr12:100614644(+) A-I intron -    22327324 chr12:100596473(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACTR6	chr12:100594549-100594550(+) m6A 5'UTR//intron       24981863 chr12:100594597-100594598(+) m6A 5'UTR//exon//intron       24284625//24981863 chr12:100594721-100594722(+) m6A 5'UTR//intron       24284625//24981863 chr12:100617659-100617660(+) m6A 3'UTR//CDS//intron       27773535 chr12:100617763-100617764(+) m6A 3'UTR//intron       27773535 chr12:100618060-100618061(+) m6A 3'UTR//intron       27773535 chr12:100618112-100618113(+) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548n	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ACTR6	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548n
Interactor2: ACTR6

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.