Basic Information:

  VIRBase ID:  

HHID00070385

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548n:  MIMAT0005916          CD2AP:  NM_012120     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548n	CD2AP
miRBase Accession/Entrez ID	MIMAT0005916	23607
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CMS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548n	rs1167799411 chr7:34940804    A/G rs1349024540 chr7:34940825    G/C rs1440338026 chr7:34940814    C/G rs1440338026 chr7:34940814    C/T rs1014154255 chr7:34940819    A/G rs1170899735 chr7:34940820    C/T rs541369935 chr7:34940820    CT/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CD2AP	chr6:47520070(+) A-I      intronic chr6:47520080(+) A-I      intronic chr6:47509005(+) A-I      intronic chr6:47584840(+) A-I      intronic chr6:47496163(+) A-I      intronic chr6:47496094(+) A-I      intronic chr6:47507763(+) A-I      intronic chr6:47507768(+) A-I      intronic chr6:47583652(+) A-I      intronic chr6:47508989(+) A-I      intronic chr6:47507789(+) A-I      intronic chr6:47508994(+) A-I      intronic chr6:47457921(+) A-I      intronic chr6:47457955(+) A-I      intronic chr6:47482713(+) A-I      intronic chr6:47475343(+) A-I      intronic chr6:47496036(+) A-I      intronic chr6:47457727(+) A-I      intronic chr6:47457728(+) A-I      intronic chr6:47457729(+) A-I      intronic chr6:47457816(+) A-I      intronic chr6:47583645(+) A-I      intronic chr6:47509001(+) A-I      intronic chr6:47583718(+) A-I      intronic chr6:47584735(+) A-I      intronic chr6:47584757(+) A-I      intronic chr6:47584783(+) A-I      intronic chr6:47584784(+) A-I      intronic chr6:47584935(+) A-I      intronic chr6:47584936(+) A-I      intronic chr6:47584940(+) A-I      intronic chr6:47585845(+) A-I      intronic chr6:47585941(+) A-I      intronic chr6:47475405(+) A-I      intronic chr6:47585945(+) A-I      intronic chr6:47545500(+) A-I      intronic chr6:47478623(+) A-I      intronic chr6:47478718(+) A-I      intronic chr6:47478751(+) A-I      intronic chr6:47482533(+) A-I      intronic chr6:47482709(+) A-I      intronic chr6:47499999(+) A-I      intronic chr6:47502233(+) A-I      intronic chr6:47502320(+) A-I      intronic chr6:47502321(+) A-I      intronic chr6:47502672(+) A-I      intronic chr6:47505549(+) A-I      intronic chr6:47505621(+) A-I      intronic chr6:47506103(+) A-I      intronic chr6:47506104(+) A-I      intronic chr6:47506167(+) A-I      intronic chr6:47506211(+) A-I      intronic chr6:47507668(+) A-I      intronic chr6:47507815(+) A-I      intronic chr6:47507660(+) A-I      intronic chr6:47570361(+) A-I      intronic chr6:47467500(+) A-I      intronic chr6:47507865(+) A-I      intronic chr6:47457781(+) A-I      intronic chr6:47584975(+) A-I      intronic chr6:47507659(+) A-I      intronic chr6:47507766(+) A-I      intronic chr6:47475321(+) A-I      intronic chr6:47507673(+) A-I      intronic chr6:47457815(+) A-I      intronic chr6:47456542(+) A-I      intronic chr6:47457908(+) A-I      intronic chr6:47510725(+) A-I      intronic chr6:47482668(+) A-I      intronic chr6:47475455(+) A-I      intronic chr6:47475403(+) A-I      intronic chr6:47546996(+) A-I      intronic chr6:47583726(+) A-I      intronic chr6:47499954(+) A-I      intronic chr6:47536432(+) A-I      intronic chr6:47507738(+) A-I      intronic chr6:47468941(+) A-I      intronic chr6:47476420(+) A-I      intronic chr6:47456506(+) A-I      intronic chr6:47546006(+) A-I      intronic chr6:47502261(+) A-I      intronic chr6:47546187(+) A-I      intronic chr6:47583655(+) A-I      intronic chr6:47546188(+) A-I      intronic chr6:47507839(+) A-I      intronic chr6:47584981(+) A-I      intronic chr6:47508881(+) A-I      intronic chr6:47536321(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CD2AP	chr6:47592459(+) A-I exon 3'UTR    15258596 chr6:47592461(+) A-I exon 3'UTR    15258596 chr6:47592463(+) A-I exon 3'UTR    15258596 chr6:47592465(+) A-I exon 3'UTR    15258596 chr6:47499163(+) A-G intron -    22484847 chr6:47456542(+) A-G intron -    22484847 chr6:47470060(+) A-T intron -    22484847 chr6:47475321(+) A-G intron -    22484847 chr6:47475403(+) A-G intron -    22484847 chr6:47475455(+) A-G intron -    22484847 chr6:47476405(+) T-C intron -    22484847 chr6:47482668(+) A-G intron -    22484847 chr6:47502261(+) A-G intron -    22484847 chr6:47506122(+) C-T intron -    22484847 chr6:47508879(+) A-G intron -    22484847 chr6:47508881(+) A-G intron -    22484847 chr6:47546187(+) A-G intron -    22484847 chr6:47546421(+) G-A intron -    22484847 chr6:47546996(+) A-G intron -    22484847 chr6:47584073(+) A-C intron -    22484847 chr6:47584846(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CD2AP	chr6:47445649-47445650(+) m6A 5'UTR       24981863 chr6:47445693-47445694(+) m6A 5'UTR       24981863 chr6:47445805-47445806(+) m6A 5'UTR       24209618 chr6:47471133-47471134(+) m6A CDS       24981863//27773535 chr6:47501438-47501439(+) m6A CDS//exon       24981863 chr6:47512399-47512400(+) m6A CDS//exon       24981863 chr6:47512469-47512470(+) m6A exon//intron       24981863 chr6:47541910-47541911(+) m6A CDS       24981863 chr6:47541935-47541936(+) m6A CDS       24981863 chr6:47541942-47541943(+) m6A CDS       24981863 chr6:47541948-47541949(+) m6A CDS       24981863//27773535 chr6:47541963-47541964(+) m6A CDS       24981863//27773535 chr6:47541977-47541978(+) m6A CDS       24981863//27773535 chr6:47544282-47544283(+) m6A CDS//exon       24981863//27773535 chr6:47544289-47544290(+) m6A CDS//exon       24981863//27773535 chr6:47544313-47544314(+) m6A CDS//exon       24981863//27773535 chr6:47544761-47544762(+) m6A CDS//exon       24981863//27773535 chr6:47544796-47544797(+) m6A CDS//exon       24981863 chr6:47547123-47547124(+) m6A CDS//exon       24981863 chr6:47547152-47547153(+) m6A CDS//exon       24981863 chr6:47547181-47547182(+) m6A CDS//exon       24981863 chr6:47547206-47547207(+) m6A CDS//exon       24981863 chr6:47547217-47547218(+) m6A CDS//exon       24981863 chr6:47548601-47548602(+) m6A CDS//exon       24981863 chr6:47548610-47548611(+) m6A CDS//exon       24981863 chr6:47549751-47549752(+) m6A CDS//exon       24981863 chr6:47549998-47549999(+) m6A exon//intron       24284625//24981863 chr6:47563615-47563616(+) m6A CDS       24284625//24981863 chr6:47563621-47563622(+) m6A CDS       24284625//24981863 chr6:47563630-47563631(+) m6A CDS       24284625//24981863 chr6:47563660-47563661(+) m6A CDS       24284625//24981863 chr6:47563706-47563707(+) m6A CDS       24284625//24981863 chr6:47563732-47563733(+) m6A CDS       24284625//24981863 chr6:47576912-47576913(+) Y CDS//exon       26075521 chr6:47576980-47576981(+) m6A CDS//exon       24981863 chr6:47577103-47577104(+) m6A exon//intron       24981863 chr6:47577175-47577176(+) m6A exon//intron       24981863 chr6:47577213-47577214(+) m6A exon//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548n	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CD2AP	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548n
Interactor2: CD2AP

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.