Basic Information:

  VIRBase ID:  

HHID00070375

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548n:  MIMAT0005916          EFR3A:  NR_136616     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548n	EFR3A
miRBase Accession/Entrez ID	MIMAT0005916	23167
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548n	rs1167799411 chr7:34940804    A/G rs1349024540 chr7:34940825    G/C rs1440338026 chr7:34940814    C/G rs1440338026 chr7:34940814    C/T rs1014154255 chr7:34940819    A/G rs1170899735 chr7:34940820    C/T rs541369935 chr7:34940820    CT/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EFR3A	chr8:132922658(+) A-I      intronic chr8:132921636(+) A-I      intronic chr8:132922550(+) A-I      intronic chr8:132921647(+) A-I      intronic chr8:132922557(+) A-I      intronic chr8:132922599(+) A-I      intronic chr8:132998934(+) A-I      intronic chr8:132921663(+) A-I      intronic chr8:132921699(+) A-I      intronic chr8:132921673(+) A-I      intronic chr8:132922794(+) A-I      intronic chr8:132921671(+) A-I      intronic chr8:132921602(+) A-I      intronic chr8:132922623(+) A-I      intronic chr8:132922648(+) A-I      intronic chr8:133006391(+) A-I      intronic chr8:132921612(+) A-I      intronic chr8:132921536(+) A-I      intronic chr8:132921616(+) A-I      intronic chr8:132921629(+) A-I      intronic chr8:132921534(+) A-I      intronic chr8:132921597(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EFR3A	chr8:132921520(+) A-G intron -    22484847 chr8:132921534(+) A-G intron -    22484847 chr8:132921536(+) A-G intron -    22484847 chr8:132921597(+) A-G intron -    22484847 chr8:132921616(+) A-G intron -    22484847 chr8:132921629(+) A-G intron -    22484847 chr8:132921651(+) A-G intron -    22484847 chr8:132921713(+) A-G intron -    22484847 chr8:132922703(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EFR3A	chr8:132958758-132958759(+) m6A CDS       - chr8:132991643-132991644(+) m6A CDS       24981863 chr8:132991648-132991649(+) m6A CDS       24981863 chr8:132996434-132996435(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548n	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	EFR3A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548n
Interactor2: EFR3A

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.