Basic Information:

  VIRBase ID:  

HHID00070186

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1255a:  MIMAT0005906          REEP3:  NM_001001330     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1255a	REEP3
miRBase Accession/Entrez ID	MIMAT0005906	221035
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C10orf74//Yip2b

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1255a	rs1338540362 chr4:101330377    T/C rs1399566309 chr4:101330378    T/C rs1400683289 chr4:101330374    T/C rs192307370 chr4:101330375    C/A rs376829388 chr4:101330371    C/T rs759895149 chr4:101330370    A/G rs762622379 chr4:101330366    ATCT/A rs770708830 chr4:101330368    C/T rs775836082 chr4:101330372    T/C rs777078205 chr4:101330367    T/A rs1243132595 chr4:101330384    T/C rs1313747940 chr4:101330380    C/T rs576769714 chr4:101330385    C/T rs761934781 chr4:101330386    C/T rs764272972 chr4:101330383    A/G rs764272972 chr4:101330383    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	REEP3	chr10:65378171(+) A-I      intronic chr10:65378145(+) A-I      intronic chr10:65372132(+) A-I      intronic chr10:65372119(+) A-I      intronic chr10:65372117(+) A-I      intronic chr10:65371657(+) A-I      intronic chr10:65371655(+) A-I      intronic chr10:65371645(+) A-I      intronic chr10:65371629(+) A-I      intronic chr10:65371625(+) A-I      intronic chr10:65371615(+) A-I      intronic chr10:65371611(+) A-I      intronic chr10:65371610(+) A-I      intronic chr10:65370712(+) A-I      intronic chr10:65370701(+) A-I      intronic chr10:65370681(+) A-I      intronic chr10:65370673(+) A-I      intronic chr10:65370671(+) A-I      intronic chr10:65340692(+) A-I      intronic chr10:65340679(+) A-I      intronic chr10:65340649(+) A-I      intronic chr10:65340635(+) A-I      intronic chr10:65330719(+) A-I      intronic chr10:65330697(+) A-I      intronic chr10:65330679(+) A-I      intronic chr10:65375508(+) A-I      intronic chr10:65285279(+) A-I      intronic chr10:65284284(+) A-I      intronic chr10:65284277(+) A-I      intronic chr10:65283211(+) A-I      intronic chr10:65371612(+) A-I      intronic chr10:65382663(+) A-I      3'UTR chr10:65382656(+) A-I      3'UTR chr10:65382650(+) A-I      3'UTR chr10:65382633(+) A-I      3'UTR chr10:65382597(+) A-I      3'UTR chr10:65378198(+) A-I      intronic chr10:65378192(+) A-I      intronic chr10:65371641(+) A-I      intronic chr10:65366167(+) A-I      intronic chr10:65283316(+) A-I      intronic chr10:65285282(+) A-I      intronic chr10:65371642(+) A-I      intronic chr10:65371958(+) A-I      intronic chr10:65372014(+) A-I      intronic chr10:65372301(+) A-I      intronic chr10:65372391(+) A-I      intronic chr10:65372952(+) A-I      intronic chr10:65294156(+) A-I      intronic chr10:65294150(+) A-I      intronic chr10:65372955(+) A-I      intronic chr10:65289362(+) A-I      intronic chr10:65294072(+) A-I      intronic chr10:65372969(+) A-I      intronic chr10:65373009(+) A-I      intronic chr10:65373017(+) A-I      intronic chr10:65283315(+) A-I      intronic chr10:65338843(+) A-I      intronic chr10:65287420(+) A-I      intronic chr10:65285243(+) A-I      intronic chr10:65366273(+) A-I      intronic chr10:65373032(+) A-I      intronic chr10:65373044(+) A-I      intronic chr10:65372295(+) A-I      intronic chr10:65373022(+) A-I      intronic chr10:65298457(+) A-I      intronic chr10:65372833(+) A-I      intronic chr10:65298396(+) A-I      intronic chr10:65372836(+) A-I      intronic chr10:65328545(+) A-I      intronic chr10:65361417(+) A-I      intronic chr10:65372115(+) A-I      intronic chr10:65328516(+) A-I      intronic chr10:65318369(+) A-I      intronic chr10:65324900(+) A-I      intronic chr10:65324857(+) A-I      intronic chr10:65292245(+) A-I      intronic chr10:65284268(+) A-I      intronic chr10:65292508(+) A-I      intronic chr10:65324212(+) A-I      intronic chr10:65338953(+) A-I      intronic chr10:65337916(+) A-I      intronic chr10:65292522(+) A-I      intronic chr10:65284669(+) A-I      intronic chr10:65294153(+) A-I      intronic chr10:65338921(+) A-I      intronic chr10:65283250(+) A-I      intronic chr10:65292543(+) A-I      intronic chr10:65303185(+) A-I      intronic chr10:65366163(+) A-I      intronic chr10:65303182(+) A-I      intronic chr10:65318340(+) A-I      intronic chr10:65338988(+) A-I      intronic chr10:65343025(+) A-I      intronic chr10:65284732(+) A-I      intronic chr10:65352426(+) A-I      intronic chr10:65338416(+) A-I      intronic chr10:65284272(+) A-I      intronic chr10:65339078(+) A-I      intronic chr10:65303181(+) A-I      intronic chr10:65303173(+) A-I      intronic chr10:65339012(+) A-I      intronic chr10:65289372(+) A-I      intronic chr10:65284737(+) A-I      intronic chr10:65294059(+) A-I      intronic chr10:65303156(+) A-I      intronic chr10:65284651(+) A-I      intronic chr10:65303133(+) A-I      intronic chr10:65303111(+) A-I      intronic chr10:65303109(+) A-I      intronic chr10:65301940(+) A-I      intronic chr10:65301926(+) A-I      intronic chr10:65301871(+) A-I      intronic chr10:65300615(+) A-I      intronic chr10:65298423(+) A-I      intronic chr10:65352464(+) A-I      intronic chr10:65372071(+) A-I      intronic chr10:65338841(+) A-I      intronic chr10:65338991(+) A-I      intronic chr10:65284262(+) A-I      intronic chr10:65341291(+) A-I      intronic chr10:65341319(+) A-I      intronic chr10:65338895(+) A-I      intronic chr10:65337977(+) A-I      intronic chr10:65338871(+) A-I      intronic chr10:65352465(+) A-I      intronic chr10:65294172(+) A-I      intronic chr10:65372009(+) A-I      intronic chr10:65352661(+) A-I      intronic chr10:65356641(+) A-I      intronic chr10:65360877(+) A-I      intronic chr10:65372060(+) A-I      intronic chr10:65337908(+) A-I      intronic chr10:65284403(+) A-I      intronic chr10:65340673(+) A-I      intronic chr10:65370645(+) A-I      intronic chr10:65284278(+) A-I      intronic chr10:65329598(+) A-I      intronic chr10:65284751(+) A-I      intronic chr10:65372444(+) A-I      intronic chr10:65329597(+) A-I      intronic chr10:65329468(+) A-I      intronic chr10:65329453(+) A-I      intronic chr10:65341396(+) A-I      intronic chr10:65382647(+) A-I      3'UTR chr10:65382596(+) A-I      3'UTR chr10:65372210(+) A-I      intronic chr10:65338343(+) A-I      intronic chr10:65337940(+) A-I      intronic chr10:65324883(+) A-I      intronic chr10:65372430(+) A-I      intronic chr10:65300581(+) A-I      intronic chr10:65330754(+) A-I      intronic chr10:65366281(+) A-I      intronic chr10:65292561(+) A-I      intronic chr10:65284408(+) A-I      intronic chr10:65309230(+) A-I      intronic chr10:65371675(+) A-I      intronic chr10:65375557(+) A-I      intronic chr10:65372216(+) A-I      intronic chr10:65356555(+) A-I      intronic chr10:65293607(+) A-I      intronic chr10:65369262(+) A-I      intronic chr10:65339053(+) A-I      intronic chr10:65342891(+) A-I      intronic chr10:65294080(+) A-I      intronic chr10:65338849(+) A-I      intronic chr10:65372152(+) A-I      intronic chr10:65361656(+) A-I      intronic chr10:65309269(+) A-I      intronic chr10:65375553(+) A-I      intronic chr10:65285318(+) A-I      intronic chr10:65338996(+) A-I      intronic chr10:65338456(+) A-I      intronic chr10:65338925(+) A-I      intronic chr10:65324249(+) A-I      intronic chr10:65303104(+) A-I      intronic chr10:65372404(+) A-I      intronic chr10:65366169(+) A-I      intronic chr10:65366272(+) A-I      intronic chr10:65372289(+) A-I      intronic chr10:65285227(+) A-I      intronic chr10:65284643(+) A-I      intronic chr10:65284296(+) A-I      intronic chr10:65372028(+) A-I      intronic chr10:65328604(+) A-I      intronic chr10:65284297(+) A-I      intronic chr10:65337989(+) A-I      intronic chr10:65338356(+) A-I      intronic chr10:65372058(+) A-I      intronic chr10:65369453(+) A-I      intronic chr10:65284389(+) A-I      intronic chr10:65285242(+) A-I      intronic chr10:65338270(+) A-I      intronic chr10:65338334(+) A-I      intronic chr10:65284705(+) A-I      intronic chr10:65292527(+) A-I      intronic chr10:65338487(+) A-I      intronic chr10:65369374(+) A-I      intronic chr10:65339056(+) A-I      intronic chr10:65338339(+) A-I      intronic chr10:65372398(+) A-I      intronic chr10:65372166(+) A-I      intronic chr10:65330819(+) A-I      intronic chr10:65283337(+) A-I      intronic chr10:65293548(+) A-I      intronic chr10:65375444(+) A-I      intronic chr10:65370685(+) A-I      intronic chr10:65283263(+) A-I      intronic chr10:65294230(+) A-I      intronic chr10:65283286(+) A-I      intronic chr10:65372167(+) A-I      intronic chr10:65283190(+) A-I      intronic chr10:65371649(+) A-I      intronic chr10:65366182(+) A-I      intronic chr10:65361583(+) A-I      intronic chr10:65294028(+) A-I      intronic chr10:65338892(+) A-I      intronic chr10:65366258(+) A-I      intronic chr10:65360652(+) A-I      intronic chr10:65322227(+) A-I      intronic chr10:65372021(+) A-I      intronic chr10:65338263(+) A-I      intronic chr10:65366196(+) A-I      intronic chr10:65330696(+) A-I      intronic chr10:65292614(+) A-I      intronic chr10:65324983(+) A-I      intronic chr10:65284351(+) A-I      intronic chr10:65293658(+) A-I      intronic chr10:65372875(+) A-I      intronic chr10:65362979(+) A-I      intronic chr10:65360864(+) A-I      intronic chr10:65292511(+) A-I      intronic chr10:65284687(+) A-I      intronic chr10:65294144(+) A-I      intronic chr10:65309221(+) A-I      intronic chr10:65382739(+) A-I      3'UTR chr10:65338394(+) A-I      intronic chr10:65293568(+) A-I      intronic chr10:65369195(+) A-I      intronic chr10:65283380(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	REEP3	chr10:65284651(+) A-G intron -    22484847 chr10:65368966(+) A-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	REEP3	chr10:65281127-65281128(+) m6A 5'UTR       24981863 chr10:65370026-65370027(+) m6A 3'UTR//CDS       24981863//27773535 chr10:65370032-65370033(+) m6A 3'UTR//CDS       24981863//27773535 chr10:65370071-65370072(+) m6A 3'UTR//CDS       24981863//27773535 chr10:65379449-65379450(+) m6A 3'UTR//CDS       24981863//27773535 chr10:65379539-65379540(+) m6A 3'UTR//CDS       24981863//27773535//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1255a	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	REEP3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1255a	Atorvastatin 60823 Drug interaction    RC00007783 Doxorubicin 31703 Drug interaction    RC00007782

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1255a	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1255a
Interactor2: REEP3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.