Detail Information

Basic Information:


  VIRBase ID:  

HHID00070151

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1255a:           ZFP36:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1255a ZFP36
miRBase
Accession/Entrez ID		 MIMAT0005906 7538
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - G0S24//GOS24//NUP475//RNF162A//TIS11//TTP//zfp-36

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1255a
rs1338540362 chr4:101330377    T/C
rs1399566309 chr4:101330378    T/C
rs1400683289 chr4:101330374    T/C
rs192307370 chr4:101330375    C/A
rs376829388 chr4:101330371    C/T
rs759895149 chr4:101330370    A/G
rs762622379 chr4:101330366    ATCT/A
rs770708830 chr4:101330368    C/T
rs775836082 chr4:101330372    T/C
rs777078205 chr4:101330367    T/A
rs1243132595 chr4:101330384    T/C
rs1313747940 chr4:101330380    C/T
rs576769714 chr4:101330385    C/T
rs761934781 chr4:101330386    C/T
rs764272972 chr4:101330383    A/G
rs764272972 chr4:101330383    A/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZFP36
chr19:39897641-39897642(+) m6A CDS//intron       24981863
chr19:39897729-39897730(+) m6A CDS//intron       24981863
chr19:39898093-39898094(+) m6A CDS//intron       25456834//24981863
chr19:39898100-39898101(+) m6A CDS//intron       25456834//24981863
chr19:39898115-39898116(+) m6A CDS//intron       25456834
chr19:39898433-39898434(+) m6A 3'UTR//CDS       25456834
chr19:39898465-39898466(+) m6A 3'UTR//CDS       24284625
chr19:39898673-39898674(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942
chr19:39898688-39898689(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942
chr19:39898792-39898793(+) m6A 3'UTR//CDS       24284625//25456834//24981863//26404942
chr19:39898869-39898870(+) m6A CDS       24284625//24209618//25456834//24981863//26404942
chr19:39898943-39898944(+) m6A CDS       24284625//24209618//25456834//24981863
chr19:39899028-39899029(+) m6A CDS       24284625//25456834//24981863
chr19:39899088-39899089(+) m6A CDS       24284625//25456834//24981863
chr19:39899168-39899169(+) m6A CDS       24284625//24981863
chr19:39899413-39899414(+) m6A 3'UTR       25456834//24981863//26404942
chr19:39899430-39899431(+) m6A 3'UTR       25456834//24981863//26404942
chr19:39899439-39899440(+) m6A 3'UTR       25456834//24981863//26404942
chr19:39899703-39899704(+) m6A 3'UTR       27773535
chr19:39899735-39899736(+) m6A 3'UTR       27773535
chr19:39899804-39899805(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1255a
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
ZFP36
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1255a
Atorvastatin 60823 Drug interaction    RC00007783
Doxorubicin 31703 Drug interaction    RC00007782
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1255a
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Crizotinib       11626560
Nvp-aew541       11476171
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1255a
Interactor2: ZFP36

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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