Basic Information:

  VIRBase ID:  

HHID00070137

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1255a:  MIMAT0005906          CRKL:  NR_156180     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1255a	CRKL
miRBase Accession/Entrez ID	MIMAT0005906	1399
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1255a	rs1338540362 chr4:101330377    T/C rs1399566309 chr4:101330378    T/C rs1400683289 chr4:101330374    T/C rs192307370 chr4:101330375    C/A rs376829388 chr4:101330371    C/T rs759895149 chr4:101330370    A/G rs762622379 chr4:101330366    ATCT/A rs770708830 chr4:101330368    C/T rs775836082 chr4:101330372    T/C rs777078205 chr4:101330367    T/A rs1243132595 chr4:101330384    T/C rs1313747940 chr4:101330380    C/T rs576769714 chr4:101330385    C/T rs761934781 chr4:101330386    C/T rs764272972 chr4:101330383    A/G rs764272972 chr4:101330383    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CRKL	chr22:21276476(+) A-I      intronic chr22:21276485(+) A-I      intronic chr22:21276491(+) A-I      intronic chr22:21276496(+) A-I      intronic chr22:21276500(+) A-I      intronic chr22:21276501(+) A-I      intronic chr22:21277943(+) A-I      intronic chr22:21287888(+) A-I      intronic chr22:21303775(+) A-I      intronic chr22:21296625(+) A-I      intronic chr22:21290297(+) A-I      intronic chr22:21277645(+) A-I      intronic chr22:21278220(+) A-I      intronic chr22:21278316(+) A-I      intronic chr22:21278344(+) A-I      intronic chr22:21278458(+) A-I      intronic chr22:21282544(+) A-I      intronic chr22:21282535(+) A-I      intronic chr22:21290289(+) A-I      intronic chr22:21290284(+) A-I      intronic chr22:21290281(+) A-I      intronic chr22:21289501(+) A-I      intronic chr22:21287906(+) A-I      intronic chr22:21282424(+) A-I      intronic chr22:21287871(+) A-I      intronic chr22:21285532(+) A-I      intronic chr22:21285492(+) A-I      intronic chr22:21281320(+) A-I      intronic chr22:21285439(+) A-I      intronic chr22:21283960(+) A-I      intronic chr22:21283122(+) A-I      intronic chr22:21283096(+) A-I      intronic chr22:21282980(+) A-I      intronic chr22:21285438(+) A-I      intronic chr22:21284748(+) A-I      intronic chr22:21284686(+) A-I      intronic chr22:21282923(+) A-I      intronic chr22:21282922(+) A-I      intronic chr22:21282910(+) A-I      intronic chr22:21282876(+) A-I      intronic chr22:21282402(+) A-I      intronic chr22:21282263(+) A-I      intronic chr22:21281349(+) A-I      intronic chr22:21281247(+) A-I      intronic chr22:21281213(+) A-I      intronic chr22:21279132(+) A-I      intronic chr22:21303783(+) A-I      intronic chr22:21282936(+) A-I      intronic chr22:21279110(+) A-I      intronic chr22:21281645(+) A-I      intronic chr22:21289640(+) A-I      intronic chr22:21276413(+) A-I      intronic chr22:21282948(+) A-I      intronic chr22:21282489(+) A-I      intronic chr22:21285432(+) A-I      intronic chr22:21290288(+) A-I      intronic chr22:21281185(+) A-I      intronic chr22:21291218(+) A-I      intronic chr22:21282248(+) A-I      intronic chr22:21297049(+) A-I      intronic chr22:21303829(+) A-I      intronic chr22:21290291(+) A-I      intronic chr22:21290223(+) A-I      intronic chr22:21279365(+) A-I      intronic chr22:21285598(+) A-I      intronic chr22:21278396(+) A-I      intronic chr22:21286199(+) A-I      intronic chr22:21277027(+) A-I      intronic chr22:21279063(+) A-I      intronic chr22:21287307(+) A-I      intronic chr22:21290296(+) A-I      intronic chr22:21283917(+) A-I      intronic chr22:21284017(+) A-I      intronic chr22:21278993(+) A-I      intronic chr22:21289581(+) A-I      intronic chr22:21290222(+) A-I      intronic chr22:21290304(+) A-I      intronic chr22:21278045(+) A-I      intronic chr22:21282408(+) A-I      intronic chr22:21277695(+) A-I      intronic chr22:21281984(+) A-I      intronic chr22:21278258(+) A-I      intronic chr22:21278293(+) A-I      intronic chr22:21297577(+) A-I      intronic chr22:21303540(+) A-I      intronic chr22:21281955(+) A-I      intronic chr22:21278984(+) A-I      intronic chr22:21290359(+) A-I      intronic chr22:21274670(+) A-I      intronic chr22:21282954(+) A-I      intronic chr22:21276400(+) A-I      intronic chr22:21278365(+) A-I      intronic chr22:21277772(+) A-I      intronic chr22:21284737(+) A-I      intronic chr22:21278249(+) A-I      intronic chr22:21282311(+) A-I      intronic chr22:21282512(+) A-I      intronic chr22:21303676(+) A-I      intronic chr22:21281700(+) A-I      intronic chr22:21285177(+) A-I      intronic chr22:21290418(+) A-I      intronic chr22:21282052(+) A-I      intronic chr22:21279408(+) A-I      intronic chr22:21274522(+) A-I      intronic chr22:21278415(+) A-I      intronic chr22:21279355(+) A-I      intronic chr22:21284011(+) A-I      intronic chr22:21278983(+) A-I      intronic chr22:21287946(+) A-I      intronic chr22:21278989(+) A-I      intronic chr22:21286229(+) A-I      intronic chr22:21290380(+) A-I      intronic chr22:21281579(+) A-I      intronic chr22:21273019(+) A-I      intronic chr22:21283931(+) A-I      intronic chr22:21303784(+) A-I      intronic chr22:21289502(+) A-I      intronic chr22:21278328(+) A-I      intronic chr22:21276561(+) A-I      intronic chr22:21285634(+) A-I      intronic chr22:21284793(+) A-I      intronic chr22:21281136(+) A-I      intronic chr22:21297628(+) A-I      intronic chr22:21290327(+) A-I      intronic chr22:21281214(+) A-I      intronic chr22:21287537(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CRKL	chr22:21307330(+) A-I exon 3'UTR    19478186 chr22:21290291(+) A-G intron -    22484847 chr22:21290327(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CRKL	chr22:21271775-21271776(+) m6A 5'UTR       24284625 chr22:21271854-21271855(+) m6A 5'UTR       24284625//22575960 chr22:21271932-21271933(+) m6A 5'UTR       24284625 chr22:21272179-21272180(+) m6A 5'UTR       24284625 chr22:21272250-21272251(+) m6A CDS       24284625 chr22:21272297-21272298(+) m6A CDS       24284625//24981863//22575960//22608085 chr22:21272361-21272362(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr22:21272385-21272386(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr22:21272445-21272446(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr22:21272502-21272503(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr22:21288142-21288143(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr22:21288176-21288177(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr22:21288228-21288229(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr22:21288248-21288249(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr22:21288360-21288361(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr22:21288388-21288389(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr22:21288462-21288463(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr22:21288514-21288515(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr22:21300943-21300944(+) Y intron       16381836 chr22:21304113-21304114(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr22:21304254-21304255(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr22:21304364-21304365(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21304451-21304452(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21304557-21304558(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21304571-21304572(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21304601-21304602(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr22:21304652-21304653(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr22:21304665-21304666(+) m6A 3'UTR//intron       24209618//24981863//22608085 chr22:21304837-21304838(+) m6A 3'UTR//intron       24209618 chr22:21304922-21304923(+) m6A 3'UTR//intron       24209618 chr22:21305004-21305005(+) m6A 3'UTR//intron       24209618 chr22:21305393-21305394(+) m6A 3'UTR//intron       24284625//24981863//26404942 chr22:21305399-21305400(+) m6A 3'UTR//intron       24284625//24981863//26404942 chr22:21305437-21305438(+) m6A 3'UTR//intron       24284625//24981863//26404942//27773535 chr22:21305478-21305479(+) m6A 3'UTR//intron       24284625//24981863//26404942//27773535 chr22:21306711-21306712(+) m6A 3'UTR//intron       24284625//24981863 chr22:21306752-21306753(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//22608085 chr22:21306761-21306762(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//22608085 chr22:21306770-21306771(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//22608085 chr22:21306827-21306828(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr22:21306893-21306894(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr22:21307031-21307032(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21307067-21307068(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21307087-21307088(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21307127-21307128(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21307185-21307186(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21307200-21307201(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr22:21307205-21307206(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr22:21307245-21307246(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr22:21307315-21307316(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr22:21307375-21307376(+) m6A 3'UTR//intron       24284625//24209618//24981863//22575960//22608085 chr22:21307461-21307462(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21307501-21307502(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21307518-21307519(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21307562-21307563(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21307630-21307631(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21307643-21307644(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21307669-21307670(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr22:21307713-21307714(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr22:21307744-21307745(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr22:21307775-21307776(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr22:21307968-21307969(+) m6A 3'UTR       27773535 chr22:21308009-21308010(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1255a	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	CRKL	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1255a	Atorvastatin 60823 Drug interaction    RC00007783 Doxorubicin 31703 Drug interaction    RC00007782

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1255a	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Crizotinib       11626560 Nvp-aew541       11476171 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1255a
Interactor2: CRKL

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.