Basic Information:

  VIRBase ID:  

HHID00070114

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1246:  MIMAT0005898          CHAMP1:  NM_001164145     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1246	CHAMP1
miRBase Accession/Entrez ID	MIMAT0005898	283489
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C13orf8//CAMP//CHAMP//MRD40//ZNF828

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1246	rs1489969781 chr2:176601041    T/C rs757265617 chr2:176601037    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CHAMP1	chr13:115082968(+) A-I      intronic chr13:115082958(+) A-I      intronic chr13:115082618(+) A-I      intronic chr13:115082915(+) A-I      intronic chr13:115082846(+) A-I      intronic chr13:115082839(+) A-I      intronic chr13:115082774(+) A-I      intronic chr13:115082682(+) A-I      intronic chr13:115082676(+) A-I      intronic chr13:115082659(+) A-I      intronic chr13:115082658(+) A-I      intronic chr13:115082654(+) A-I      intronic chr13:115082622(+) A-I      intronic chr13:115082610(+) A-I      intronic chr13:115082597(+) A-I      intronic chr13:115082593(+) A-I      intronic chr13:115082592(+) A-I      intronic chr13:115082548(+) A-I      intronic chr13:115082851(+) A-I      intronic chr13:115082525(+) A-I      intronic chr13:115082867(+) A-I      intronic chr13:115081412(+) A-I      intronic chr13:115083044(+) A-I      intronic chr13:115082988(+) A-I      intronic chr13:115082984(+) A-I      intronic chr13:115083111(+) A-I      intronic chr13:115082976(+) A-I      intronic chr13:115083024(+) A-I      intronic chr13:115082045(+) A-I      intronic chr13:115082949(+) A-I      intronic chr13:115081669(+) A-I      intronic chr13:115082894(+) A-I      intronic chr13:115082899(+) A-I      intronic chr13:115081739(+) A-I      intronic chr13:115087774(+) A-I      intronic chr13:115082634(+) A-I      intronic chr13:115082992(+) A-I      intronic chr13:115082693(+) A-I      intronic chr13:115083106(+) A-I      intronic chr13:115083877(+) A-I      intronic chr13:115082762(+) A-I      intronic chr13:115082956(+) A-I      intronic chr13:115082573(+) A-I      intronic chr13:115082845(+) A-I      intronic chr13:115081386(+) A-I      intronic chr13:115082919(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CHAMP1	chr13:115089309-115089310(+) m6A 5'UTR       24284625//25456834//24981863//22575960//22608085 chr13:115089334-115089335(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr13:115089343-115089344(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr13:115089390-115089391(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:115089568-115089569(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:115089582-115089583(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:115089598-115089599(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:115089615-115089616(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:115089623-115089624(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr13:115089655-115089656(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr13:115089685-115089686(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr13:115089716-115089717(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089724-115089725(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089757-115089758(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089790-115089791(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089821-115089822(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089850-115089851(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089874-115089875(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089910-115089911(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089934-115089935(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089943-115089944(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115089994-115089995(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115090022-115090023(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115090081-115090082(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090090-115090091(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090133-115090134(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090180-115090181(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090222-115090223(+) m6A CDS       24284625//24209618//25456834//22575960 chr13:115090255-115090256(+) m6A CDS       24284625//24209618//25456834//22575960 chr13:115090312-115090313(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090330-115090331(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090354-115090355(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090363-115090364(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090387-115090388(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090396-115090397(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090504-115090505(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115090514-115090515(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115090537-115090538(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115090579-115090580(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr13:115090639-115090640(+) m6A CDS       24284625 chr13:115090688-115090689(+) m6A CDS       24284625 chr13:115090786-115090787(+) m6A CDS       24284625//24981863 chr13:115090802-115090803(+) m6A CDS       24284625//24209618//24981863//22575960 chr13:115090810-115090811(+) m6A CDS       24284625//24209618//24981863//22575960 chr13:115090897-115090898(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115090925-115090926(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:115091002-115091003(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr13:115091059-115091060(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr13:115091113-115091114(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr13:115091134-115091135(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr13:115091181-115091182(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr13:115091231-115091232(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr13:115091322-115091323(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr13:115091331-115091332(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr13:115091662-115091663(+) m6A CDS       24981863//26404942//22608085 chr13:115091728-115091729(+) m6A CDS       24981863//26404942//22608085 chr13:115091798-115091799(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1246	Exosome Sera     25388097 Exosome Human cervical cancer cell line (HeLa)     25760330 Exosome Saliva     27573701 Exosome Plasma     29143228 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Plasma     23663360 Exosome Serum     24683445 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Blood|B lymphoblastoid cells|Breast tissue|Colon tissue|Epithelial cells|Lymphoma tissue|Mast cells|Mesenchymal stem cells|Tongue tissue     - Extracellular vesicle Plasma     32498409 Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	CHAMP1	Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1246	10-Hydroxycamptothecin 97226 Drug interaction    RC00007762 Gemcitabine 60750 Drug interaction    RC00007761 Vincristine 5978 Drug interaction    RC00007758 Ascorbic acid 54670067 Drug interaction    RC00007765 Vorinostat 5311 Drug interaction    RC00007757 Eloxatine 5310940 Drug interaction    RC00007764 Bortezomib 387447 Drug interaction    RC00007763 Paclitaxel 36314 Drug interaction    RC00007760 5-Fluorouracil 3385 Drug interaction    RC00007756 Doxorubicin 31703 Drug interaction    RC00007759 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007755 Trastuzumab - Drug interaction    RC00007768 platinum-based doublet chemotherapy - Drug interaction    RC00007766 Marine fungal metabolite 1386A - Drug interaction    RC00007767

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1246	Panobinostat       6918837 Irinotecan       60838 Lapatinib       208908

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1246
Interactor2: CHAMP1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.