Basic Information:

  VIRBase ID:  

HHID00069911

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1304-5p:  MIMAT0005892          PSME3:  NR_049772     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1304-5p	PSME3
miRBase Accession/Entrez ID	MIMAT0005892	10197
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HEL-S-283//Ki//PA28-gamma//PA28G//PA28gamma//REG-GAMMA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1304-5p	rs1360520725 chr11:93733726    C/T rs1362552303 chr11:93733733    C/T rs749880345 chr11:93733735    G/A rs749880345 chr11:93733735    G/T rs780506580 chr11:93733725    A/C rs1411147958 chr11:93733742    C/T rs748549386 chr11:93733740    C/A rs76857625 chr11:93733744    A/G rs779470949 chr11:93733739    C/T rs780392471 chr11:93733739    C/CATTGAGCCCAGGGGTT rs79759099 chr11:93733743    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PSME3	chr17:40988663(+) A-I      intronic chr17:40988706(+) A-I      intronic chr17:40988694(+) A-I      intronic chr17:40988689(+) A-I      intronic chr17:40988677(+) A-I      intronic chr17:40987076(+) A-I      intronic chr17:40987582(+) A-I      intronic chr17:40987663(+) A-I      intronic chr17:40987119(+) A-I      intronic chr17:40987563(+) A-I      intronic chr17:40989402(+) A-I      intronic chr17:40987662(+) A-I      intronic chr17:40987659(+) A-I      intronic chr17:40987654(+) A-I      intronic chr17:40988222(+) A-I      intronic chr17:40988121(+) A-I      intronic chr17:40987667(+) A-I      intronic chr17:40987583(+) A-I      intronic chr17:40987073(+) A-I      intronic chr17:40987540(+) A-I      intronic chr17:40987077(+) A-I      intronic chr17:40987692(+) A-I      intronic chr17:40987099(+) A-I      intronic chr17:40987488(+) A-I      intronic chr17:40987557(+) A-I      intronic chr17:40987085(+) A-I      intronic chr17:40987621(+) A-I      intronic chr17:40989146(+) A-I      intronic chr17:40987589(+) A-I      intronic chr17:40987555(+) A-I      intronic chr17:40988122(+) A-I      intronic chr17:40988091(+) A-I      intronic chr17:40987254(+) A-I      intronic chr17:40987565(+) A-I      intronic chr17:40987504(+) A-I      intronic chr17:40987184(+) A-I      intronic chr17:40988134(+) A-I      intronic chr17:40987595(+) A-I      intronic chr17:40992318(+) A-I      intronic chr17:40987487(+) A-I      intronic chr17:40987239(+) A-I      intronic chr17:40987149(+) A-I      intronic chr17:40987648(+) A-I      intronic chr17:40987592(+) A-I      intronic chr17:40988156(+) A-I      intronic chr17:40988196(+) A-I      intronic chr17:40987155(+) A-I      intronic chr17:40988187(+) A-I      intronic chr17:40987539(+) A-I      intronic chr17:40989476(+) A-I      intronic chr17:40988161(+) A-I      intronic chr17:40988054(+) A-I      intronic chr17:40992193(+) A-I      intronic chr17:40987631(+) A-I      intronic chr17:40987564(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PSME3	chr17:40987621(+) A-G intron -    22484847 chr17:40987648(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PSME3	chr17:40985036-40985037(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773536//22608085 chr17:40985630-40985631(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//22575960//22608085 chr17:40986790-40986791(+) m6A 3'UTR//5'UTR//CDS//exon//intron       26404942 chr17:40986801-40986802(+) m6A 3'UTR//5'UTR//CDS//exon//intron       26404942 chr17:40986883-40986884(+) m6A 3'UTR//CDS//exon//intron       26404942 chr17:40993583-40993584(+) m6A 3'UTR//CDS       25456834//24981863//26404942//27773535//22575960//22608085 chr17:40993616-40993617(+) m6A 3'UTR       25456834//24981863//26404942//27773535//22575960//22608085 chr17:40993637-40993638(+) m6A 3'UTR       25456834//24981863//27773535//22575960//22608085 chr17:40993681-40993682(+) m6A 3'UTR       25456834//24981863//27773535//22575960//22608085 chr17:40993734-40993735(+) m6A 3'UTR       22608085 chr17:40993997-40993998(+) Y 3'UTR       25219674 chr17:40994254-40994255(+) m6A 3'UTR       26404942 chr17:40994268-40994269(+) m6A 3'UTR       26404942 chr17:40994363-40994364(+) m6A 3'UTR       26404942 chr17:40995036-40995037(+) m6A 3'UTR       24284625//26404942//27773535 chr17:40995096-40995097(+) m6A 3'UTR       24981863//27773535 chr17:40995148-40995149(+) m6A 3'UTR       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1304-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PSME3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1304-5p
Interactor2: PSME3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.