Basic Information:

  VIRBase ID:  

HHID00069688

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1299:  MIMAT0005887          ACTR2:  NM_001005386     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1299	ACTR2
miRBase Accession/Entrez ID	MIMAT0005887	10097
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARP2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1299	rs1009712608 chr9:40929012    C/T rs747216379 chr9:40929013    C/G rs747216379 chr9:40929013    C/T rs753922180 chr9:40928993    GAGGGTCTGAATGTTTGTCCC/G rs796108267 chr9:40929011    C/T rs796728500 chr9:40929010    T/C rs1042551075 chr9:40929028    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ACTR2	chr2:65496906(+) A-I      3'UTR chr2:65489876(+) A-I      intronic chr2:65480550(+) A-I      intronic chr2:65480507(+) A-I      intronic chr2:65480510(+) A-I      intronic chr2:65480518(+) A-I      intronic chr2:65496864(+) A-I      3'UTR chr2:65480527(+) A-I      intronic chr2:65496865(+) A-I      3'UTR chr2:65496866(+) A-I      3'UTR chr2:65462724(+) A-I      intronic chr2:65491069(+) A-I      intronic chr2:65489958(+) A-I      intronic chr2:65489842(+) A-I      intronic chr2:65489637(+) A-I      intronic chr2:65488126(+) A-I      intronic chr2:65488111(+) A-I      intronic chr2:65488086(+) A-I      intronic chr2:65488055(+) A-I      intronic chr2:65488049(+) A-I      intronic chr2:65488040(+) A-I      intronic chr2:65487623(+) A-I      intronic chr2:65487585(+) A-I      intronic chr2:65487533(+) A-I      intronic chr2:65487457(+) A-I      intronic chr2:65464610(+) A-I      intronic chr2:65464775(+) A-I      intronic chr2:65487378(+) A-I      intronic chr2:65486200(+) A-I      intronic chr2:65463314(+) A-I      intronic chr2:65480593(+) A-I      intronic chr2:65491074(+) A-I      intronic chr2:65480469(+) A-I      intronic chr2:65480390(+) A-I      intronic chr2:65491146(+) A-I      intronic chr2:65491149(+) A-I      intronic chr2:65463326(+) A-I      intronic chr2:65463402(+) A-I      intronic chr2:65463415(+) A-I      intronic chr2:65463815(+) A-I      intronic chr2:65463832(+) A-I      intronic chr2:65480349(+) A-I      intronic chr2:65480333(+) A-I      intronic chr2:65480324(+) A-I      intronic chr2:65485569(+) A-I      intronic chr2:65479720(+) A-I      intronic chr2:65479690(+) A-I      intronic chr2:65463854(+) A-I      intronic chr2:65463880(+) A-I      intronic chr2:65463881(+) A-I      intronic chr2:65456640(+) A-I      intronic chr2:65456792(+) A-I      intronic chr2:65479511(+) A-I      intronic chr2:65478747(+) A-I      intronic chr2:65478715(+) A-I      intronic chr2:65478622(+) A-I      intronic chr2:65472082(+) A-I      intronic chr2:65471880(+) A-I      intronic chr2:65464867(+) A-I      intronic chr2:65464832(+) A-I      intronic chr2:65456802(+) A-I      intronic chr2:65457645(+) A-I      intronic chr2:65457992(+) A-I      intronic chr2:65458143(+) A-I      intronic chr2:65460911(+) A-I      intronic chr2:65460912(+) A-I      intronic chr2:65460919(+) A-I      intronic chr2:65460928(+) A-I      intronic chr2:65463313(+) A-I      intronic chr2:65462742(+) A-I      intronic chr2:65457851(+) A-I      intronic chr2:65457856(+) A-I      intronic chr2:65463311(+) A-I      intronic chr2:65456093(+) A-I      intronic chr2:65456139(+) A-I      intronic chr2:65457933(+) A-I      intronic chr2:65458094(+) A-I      intronic chr2:65486171(+) A-I      intronic chr2:65464426(+) A-I      intronic chr2:65457807(+) A-I      intronic chr2:65458023(+) A-I      intronic chr2:65458067(+) A-I      intronic chr2:65456006(+) A-I      intronic chr2:65463395(+) A-I      intronic chr2:65456174(+) A-I      intronic chr2:65464893(+) A-I      intronic chr2:65456103(+) A-I      intronic chr2:65456099(+) A-I      intronic chr2:65486677(+) A-I      intronic chr2:65463899(+) A-I      intronic chr2:65480590(+) A-I      intronic chr2:65460258(+) A-I      intronic chr2:65458077(+) A-I      intronic chr2:65464628(+) A-I      intronic chr2:65478697(+) A-I      intronic chr2:65457750(+) A-I      intronic chr2:65479954(+) A-I      intronic chr2:65456811(+) A-I      intronic chr2:65458030(+) A-I      intronic chr2:65462729(+) A-I      intronic chr2:65461314(+) A-I      intronic chr2:65458084(+) A-I      intronic chr2:65487520(+) A-I      intronic chr2:65458032(+) A-I      intronic chr2:65458103(+) A-I      intronic chr2:65456125(+) A-I      intronic chr2:65458066(+) A-I      intronic chr2:65487392(+) A-I      intronic chr2:65461060(+) A-I      intronic chr2:65456155(+) A-I      intronic chr2:65479912(+) A-I      intronic chr2:65458100(+) A-I      intronic chr2:65456143(+) A-I      intronic chr2:65457663(+) A-I      intronic chr2:65464485(+) A-I      intronic chr2:65455998(+) A-I      intronic chr2:65464615(+) A-I      intronic chr2:65456134(+) A-I      intronic chr2:65455988(+) A-I      intronic chr2:65456135(+) A-I      intronic chr2:65463825(+) A-I      intronic chr2:65458012(+) A-I      intronic chr2:65456713(+) A-I      intronic chr2:65486168(+) A-I      intronic chr2:65464839(+) A-I      intronic chr2:65458719(+) A-I      intronic chr2:65486127(+) A-I      intronic chr2:65458073(+) A-I      intronic chr2:65456067(+) A-I      intronic chr2:65457819(+) A-I      intronic chr2:65456184(+) A-I      intronic chr2:65479519(+) A-I      intronic chr2:65458097(+) A-I      intronic chr2:65456120(+) A-I      intronic chr2:65458109(+) A-I      intronic chr2:65460312(+) A-I      intronic chr2:65458730(+) A-I      intronic chr2:65491012(+) A-I      intronic chr2:65479978(+) A-I      intronic chr2:65487464(+) A-I      intronic chr2:65458760(+) A-I      intronic chr2:65458120(+) A-I      intronic chr2:65490986(+) A-I      intronic chr2:65489993(+) A-I      intronic chr2:65460255(+) A-I      intronic chr2:65478635(+) A-I      intronic chr2:65456708(+) A-I      intronic chr2:65461019(+) A-I      intronic chr2:65457626(+) A-I      intronic chr2:65470426(+) A-I      intronic chr2:65456730(+) A-I      intronic chr2:65489875(+) A-I      intronic chr2:65461123(+) A-I      intronic chr2:65491134(+) A-I      intronic chr2:65461028(+) A-I      intronic chr2:65457602(+) A-I      intronic chr2:65457806(+) A-I      intronic chr2:65463856(+) A-I      intronic chr2:65456094(+) A-I      intronic chr2:65490290(+) A-I      intronic chr2:65485575(+) A-I      intronic chr2:65489989(+) A-I      intronic chr2:65490291(+) A-I      intronic chr2:65487465(+) A-I      intronic chr2:65457569(+) A-I      intronic chr2:65489428(+) A-I      intronic chr2:65488071(+) A-I      intronic chr2:65480477(+) A-I      intronic chr2:65489498(+) A-I      intronic chr2:65456769(+) A-I      intronic chr2:65456732(+) A-I      intronic chr2:65486311(+) A-I      intronic chr2:65478769(+) A-I      intronic chr2:65470506(+) A-I      intronic chr2:65463270(+) A-I      intronic chr2:65487393(+) A-I      intronic chr2:65485591(+) A-I      intronic chr2:65486826(+) A-I      intronic chr2:65480345(+) A-I      intronic chr2:65457938(+) A-I      intronic chr2:65480455(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ACTR2	chr2:65455988(+) A-I intron -    22028664 chr2:65455998(+) A-I intron -    22028664 chr2:65456006(+) A-I intron -    22028664 chr2:65456022(+) A-I intron -    22028664 chr2:65456052(+) A-I intron -    22028664 chr2:65456067(+) A-I intron -    22028664 chr2:65456093(+) A-I intron -    22028664 chr2:65456094(+) A-I intron -    22028664 chr2:65456099(+) A-I intron -    22028664 chr2:65456103(+) A-I intron -    22028664 chr2:65456120(+) A-I intron -    22028664 chr2:65456125(+) A-I intron -    22028664 chr2:65456134(+) A-I intron -    22028664 chr2:65456135(+) A-I intron -    22028664 chr2:65456139(+) A-I intron -    22028664 chr2:65456143(+) A-I intron -    22028664 chr2:65456155(+) A-I intron -    22028664 chr2:65456174(+) A-I intron -    22028664 chr2:65456184(+) A-I intron -    22028664 chr2:65457806(+) A-I intron -    22028664 chr2:65457807(+) A-I intron -    22028664 chr2:65457813(+) A-I intron -    22028664 chr2:65457819(+) A-I intron -    22028664 chr2:65457851(+) A-I intron -    22028664 chr2:65457856(+) A-I intron -    22028664 chr2:65457861(+) A-I intron -    22028664 chr2:65457932(+) A-I intron -    22028664 chr2:65457933(+) A-I intron -    22028664 chr2:65457938(+) A-I intron -    22028664 chr2:65457959(+) A-I intron -    22028664 chr2:65458012(+) A-I intron -    22028664 chr2:65458023(+) A-I intron -    22028664 chr2:65458029(+) A-I intron -    22028664 chr2:65458030(+) A-I intron -    22028664 chr2:65458066(+) A-I intron -    22028664 chr2:65458067(+) A-I intron -    22028664 chr2:65458068(+) A-I intron -    22028664 chr2:65458073(+) A-I intron -    22028664 chr2:65458077(+) A-I intron -    22028664 chr2:65458084(+) A-I intron -    22028664 chr2:65458094(+) A-I intron -    22028664 chr2:65458097(+) A-I intron -    22028664 chr2:65458100(+) A-I intron -    22028664 chr2:65458103(+) A-I intron -    22028664 chr2:65458109(+) A-I intron -    22028664 chr2:65487520(+) A-I intron -    21960545 chr2:65456769(+) A-G intron -    22484847 chr2:65457569(+) A-G intron -    22484847 chr2:65457626(+) A-G intron -    22484847 chr2:65457646(+) A-G intron -    22484847 chr2:65457663(+) A-G intron -    22484847 chr2:65457807(+) A-G intron -    22484847 chr2:65457813(+) A-G intron -    22484847 chr2:65457932(+) A-G intron -    22484847 chr2:65457933(+) A-G intron -    22484847 chr2:65457938(+) A-G intron -    22484847 chr2:65457959(+) A-G intron -    22484847 chr2:65458011(+) A-G intron -    22484847 chr2:65458029(+) A-G intron -    22484847 chr2:65458030(+) A-G intron -    22484847 chr2:65458041(+) A-G intron -    22484847 chr2:65458068(+) A-G intron -    22484847 chr2:65458120(+) A-G intron -    22484847 chr2:65462729(+) A-G intron -    22484847 chr2:65463311(+) A-G intron -    22484847 chr2:65463394(+) T-C intron -    22484847 chr2:65463395(+) A-G intron -    22484847 chr2:65463789(+) A-G intron -    22484847 chr2:65463825(+) A-G intron -    22484847 chr2:65463856(+) A-G intron -    22484847 chr2:65463896(+) A-G intron -    22484847 chr2:65464480(+) A-G intron -    22484847 chr2:65464485(+) A-G intron -    22484847 chr2:65464893(+) A-G intron -    22484847 chr2:65478552(+) A-G intron -    22484847 chr2:65478554(+) A-G intron -    22484847 chr2:65478573(+) A-G intron -    22484847 chr2:65478635(+) A-G intron -    22484847 chr2:65478641(+) A-G intron -    22484847 chr2:65478697(+) A-G intron -    22484847 chr2:65480345(+) A-G intron -    22484847 chr2:65486168(+) A-G intron -    22484847 chr2:65486513(+) A-G intron -    22484847 chr2:65486779(+) T-C intron -    22484847 chr2:65486826(+) A-G intron -    22484847 chr2:65487392(+) A-G intron -    22484847 chr2:65487393(+) A-G intron -    22484847 chr2:65487403(+) A-G intron -    22484847 chr2:65487417(+) A-G intron -    22484847 chr2:65487464(+) A-G intron -    22484847 chr2:65487465(+) A-G intron -    22484847 chr2:65487520(+) A-G intron -    22484847 chr2:65487529(+) A-G intron -    22484847 chr2:65487882(+) G-T intron -    22484847 chr2:65487994(+) A-G intron -    22484847 chr2:65488071(+) A-G intron -    22484847 chr2:65488116(+) A-G intron -    22484847 chr2:65489427(+) A-G intron -    22484847 chr2:65489428(+) A-G intron -    22484847 chr2:65489875(+) A-G intron -    22484847 chr2:65489957(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACTR2	chr2:65454975-65454976(+) m1A 5'UTR//exon       26863196//26863410 chr2:65455047-65455048(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr2:65455329-65455330(+) m6A 5'UTR//intron       - chr2:65455340-65455341(+) m6A 5'UTR//intron       - chr2:65455369-65455370(+) m6A 5'UTR//intron       - chr2:65467023-65467024(+) m6A 5'UTR//CDS//exon       24209618//25456834//24981863//27773535 chr2:65467050-65467051(+) m6A 5'UTR//CDS//exon       24209618//27773535 chr2:65467082-65467083(+) m6A 5'UTR//CDS//exon       24209618//27773535 chr2:65473755-65473756(+) m6A CDS//exon       22575960 chr2:65473766-65473767(+) m6A CDS//exon       22575960 chr2:65473779-65473780(+) m6A CDS//exon       22575960 chr2:65495719-65495720(+) m6A CDS       24284625 chr2:65495782-65495783(+) m6A CDS       24284625//24981863//22608085 chr2:65495788-65495789(+) m6A CDS       24284625//24981863//22608085 chr2:65495846-65495847(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr2:65495868-65495869(+) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr2:65495932-65495933(+) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr2:65495949-65495950(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr2:65496387-65496388(+) m6A 3'UTR       - chr2:65496414-65496415(+) m6A 3'UTR       - chr2:65497780-65497781(+) m6A 3'UTR       24981863//27773535 chr2:65497799-65497800(+) m6A 3'UTR       24981863//27773535 chr2:65497808-65497809(+) m6A 3'UTR       24981863//27773535 chr2:65498201-65498202(+) m6A 3'UTR       27773535 chr2:65498220-65498221(+) m6A 3'UTR       27773535 chr2:65498235-65498236(+) m6A 3'UTR       27773535 chr2:65498319-65498320(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1299	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular Vesicle Plasma     28588009 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ACTR2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1299	Gemcitabine 60750 Drug interaction    RC00007746 Eloxatine 5310940 Drug interaction    RC00007748 Doxorubicin 31703 Drug interaction    RC00007745 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007744

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1299	Topotecan       60700 l-685,458       5479543 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1299
Interactor2: ACTR2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.