Basic Information:

  VIRBase ID:  

HHID00069651

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1294:  MIMAT0005884          PHF12:  NM_001033561     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1294	PHF12
miRBase Accession/Entrez ID	MIMAT0005884	57649
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PF1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1294	rs1162939290 chr5:154347163    G/T rs1179835339 chr5:154347171    G/GTATA rs1237976003 chr5:154347166    T/C rs1255234532 chr5:154347174    T/A rs1465013068 chr5:154347169    T/C rs189565536 chr5:154347168    G/T rs1211754242 chr5:154347158    G/A rs1341512450 chr5:154347155    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PHF12	chr17:27269642(-) A-I      intronic chr17:27269751(-) A-I      intronic chr17:27269758(-) A-I      intronic chr17:27270402(-) A-I      intronic chr17:27270418(-) A-I      intronic chr17:27270561(-) A-I      intronic chr17:27270566(-) A-I      intronic chr17:27270586(-) A-I      intronic chr17:27270642(-) A-I      intronic chr17:27271589(-) A-I      intronic chr17:27271659(-) A-I      intronic chr17:27272170(-) A-I      intronic chr17:27274130(-) A-I      intronic chr17:27274496(-) A-I      intronic chr17:27250015(-) A-I      intronic chr17:27243348(-) A-I      intronic chr17:27243357(-) A-I      intronic chr17:27249974(-) A-I      intronic chr17:27249976(-) A-I      intronic chr17:27256428(-) A-I      intronic chr17:27257968(-) A-I      intronic chr17:27257978(-) A-I      intronic chr17:27257982(-) A-I      intronic chr17:27258014(-) A-I      intronic chr17:27258021(-) A-I      intronic chr17:27258035(-) A-I      intronic chr17:27259344(-) A-I      intronic chr17:27259351(-) A-I      intronic chr17:27259364(-) A-I      intronic chr17:27259397(-) A-I      intronic chr17:27259398(-) A-I      intronic chr17:27259801(-) A-I      intronic chr17:27259815(-) A-I      intronic chr17:27259816(-) A-I      intronic chr17:27259820(-) A-I      intronic chr17:27261813(-) A-I      intronic chr17:27261820(-) A-I      intronic chr17:27259338(-) A-I      intronic chr17:27268705(-) A-I      intronic chr17:27268728(-) A-I      intronic chr17:27268801(-) A-I      intronic chr17:27268802(-) A-I      intronic chr17:27268818(-) A-I      intronic chr17:27268826(-) A-I      intronic chr17:27274549(-) A-I      intronic chr17:27255007(-) A-I      intronic chr17:27255098(-) A-I      intronic chr17:27258065(-) A-I      intronic chr17:27258073(-) A-I      intronic chr17:27258385(-) A-I      intronic chr17:27258411(-) A-I      intronic chr17:27258453(-) A-I      intronic chr17:27258457(-) A-I      intronic chr17:27259353(-) A-I      intronic chr17:27259371(-) A-I      intronic chr17:27259792(-) A-I      intronic chr17:27259901(-) A-I      intronic chr17:27260883(-) A-I      intronic chr17:27261003(-) A-I      intronic chr17:27261756(-) A-I      intronic chr17:27261851(-) A-I      intronic chr17:27265385(-) A-I      intronic chr17:27265386(-) A-I      intronic chr17:27268718(-) A-I      intronic chr17:27268730(-) A-I      intronic chr17:27268733(-) A-I      intronic chr17:27268800(-) A-I      intronic chr17:27268803(-) A-I      intronic chr17:27268804(-) A-I      intronic chr17:27268871(-) A-I      intronic chr17:27268875(-) A-I      intronic chr17:27269444(-) A-I      intronic chr17:27243361(-) A-I      intronic chr17:27243369(-) A-I      intronic chr17:27246534(-) A-I      intronic chr17:27246658(-) A-I      intronic chr17:27246672(-) A-I      intronic chr17:27246676(-) A-I      intronic chr17:27246721(-) A-I      intronic chr17:27247719(-) A-I      intronic chr17:27247754(-) A-I      intronic chr17:27247759(-) A-I      intronic chr17:27247763(-) A-I      intronic chr17:27247846(-) A-I      intronic chr17:27262569(-) A-I      intronic chr17:27255934(-) A-I      intronic chr17:27265501(-) A-I      intronic chr17:27268691(-) A-I      intronic chr17:27268727(-) A-I      intronic chr17:27256112(-) A-I      intronic chr17:27258738(-) A-I      intronic chr17:27258774(-) A-I      intronic chr17:27258794(-) A-I      intronic chr17:27258837(-) A-I      intronic chr17:27259278(-) A-I      intronic chr17:27259298(-) A-I      intronic chr17:27274452(-) A-I      intronic chr17:27274430(-) A-I      intronic chr17:27274424(-) A-I      intronic chr17:27274200(-) A-I      intronic chr17:27274178(-) A-I      intronic chr17:27274177(-) A-I      intronic chr17:27274126(-) A-I      intronic chr17:27273829(-) A-I      intronic chr17:27270596(-) A-I      intronic chr17:27270526(-) A-I      intronic chr17:27270443(-) A-I      intronic chr17:27268880(-) A-I      intronic chr17:27268828(-) A-I      intronic chr17:27268813(-) A-I      intronic chr17:27268807(-) A-I      intronic chr17:27268790(-) A-I      intronic chr17:27259314(-) A-I      intronic chr17:27259319(-) A-I      intronic chr17:27259320(-) A-I      intronic chr17:27259433(-) A-I      intronic chr17:27259734(-) A-I      intronic chr17:27259747(-) A-I      intronic chr17:27259798(-) A-I      intronic chr17:27259839(-) A-I      intronic chr17:27259864(-) A-I      intronic chr17:27259881(-) A-I      intronic chr17:27259895(-) A-I      intronic chr17:27260821(-) A-I      intronic chr17:27260822(-) A-I      intronic chr17:27261822(-) A-I      intronic chr17:27261861(-) A-I      intronic chr17:27260921(-) A-I      intronic chr17:27262368(-) A-I      intronic chr17:27262414(-) A-I      intronic chr17:27262427(-) A-I      intronic chr17:27262554(-) A-I      intronic chr17:27243285(-) A-I      intronic chr17:27260953(-) A-I      intronic chr17:27268753(-) A-I      intronic chr17:27262556(-) A-I      intronic chr17:27262562(-) A-I      intronic chr17:27260836(-) A-I      intronic chr17:27260848(-) A-I      intronic chr17:27259842(-) A-I      intronic chr17:27260982(-) A-I      intronic chr17:27261063(-) A-I      intronic chr17:27261714(-) A-I      intronic chr17:27261789(-) A-I      intronic chr17:27260897(-) A-I      intronic chr17:27261792(-) A-I      intronic chr17:27261818(-) A-I      intronic chr17:27258737(-) A-I      intronic chr17:27258732(-) A-I      intronic chr17:27258052(-) A-I      intronic chr17:27258051(-) A-I      intronic chr17:27257990(-) A-I      intronic chr17:27257942(-) A-I      intronic chr17:27257926(-) A-I      intronic chr17:27256544(-) A-I      intronic chr17:27256451(-) A-I      intronic chr17:27256417(-) A-I      intronic chr17:27256385(-) A-I      intronic chr17:27256032(-) A-I      intronic chr17:27255857(-) A-I      intronic chr17:27255856(-) A-I      intronic chr17:27255762(-) A-I      intronic chr17:27255753(-) A-I      intronic chr17:27255723(-) A-I      intronic chr17:27255716(-) A-I      intronic chr17:27255692(-) A-I      intronic chr17:27255688(-) A-I      intronic chr17:27255678(-) A-I      intronic chr17:27255676(-) A-I      intronic chr17:27255668(-) A-I      intronic chr17:27255612(-) A-I      intronic chr17:27255060(-) A-I      intronic chr17:27255052(-) A-I      intronic chr17:27255046(-) A-I      intronic chr17:27255043(-) A-I      intronic chr17:27255021(-) A-I      intronic chr17:27249391(-) A-I      intronic chr17:27249283(-) A-I      intronic chr17:27248457(-) A-I      intronic chr17:27248398(-) A-I      intronic chr17:27259933(-) A-I      intronic chr17:27272105(-) A-I      intronic chr17:27259952(-) A-I      intronic chr17:27260943(-) A-I      intronic chr17:27243345(-) A-I      intronic chr17:27247851(-) A-I      intronic chr17:27249266(-) A-I      intronic chr17:27274183(-) A-I      intronic chr17:27249279(-) A-I      intronic chr17:27259304(-) A-I      intronic chr17:27273850(-) A-I      intronic chr17:27259877(-) A-I      intronic chr17:27272166(-) A-I      intronic chr17:27249311(-) A-I      intronic chr17:27246560(-) A-I      intronic chr17:27249218(-) A-I      intronic chr17:27269372(-) A-I      intronic chr17:27249245(-) A-I      intronic chr17:27256108(-) A-I      intronic chr17:27272108(-) A-I      intronic chr17:27259349(-) A-I      intronic chr17:27273752(-) A-I      intronic chr17:27273823(-) A-I      intronic chr17:27269452(-) A-I      intronic chr17:27269366(-) A-I      intronic chr17:27270565(-) A-I      intronic chr17:27256398(-) A-I      intronic chr17:27272195(-) A-I      intronic chr17:27256421(-) A-I      intronic chr17:27270490(-) A-I      intronic chr17:27249330(-) A-I      intronic chr17:27260845(-) A-I      intronic chr17:27274069(-) A-I      intronic chr17:27272111(-) A-I      intronic chr17:27243486(-) A-I      intronic chr17:27257995(-) A-I      intronic chr17:27249275(-) A-I      intronic chr17:27248087(-) A-I      intronic chr17:27258384(-) A-I      intronic chr17:27270485(-) A-I      intronic chr17:27248083(-) A-I      intronic chr17:27235428(-) A-I      intronic chr17:27258879(-) A-I      intronic chr17:27249931(-) A-I      intronic chr17:27249328(-) A-I      intronic chr17:27243341(-) A-I      intronic chr17:27255948(-) A-I      intronic chr17:27274087(-) A-I      intronic chr17:27259955(-) A-I      intronic chr17:27243393(-) A-I      intronic chr17:27246521(-) A-I      intronic chr17:27249385(-) A-I      intronic chr17:27243240(-) A-I      intronic chr17:27273847(-) A-I      intronic chr17:27247686(-) A-I      intronic chr17:27272157(-) A-I      intronic chr17:27274488(-) A-I      intronic chr17:27270479(-) A-I      intronic chr17:27258873(-) A-I      intronic chr17:27241652(-) A-I      intronic chr17:27243350(-) A-I      intronic chr17:27258846(-) A-I      intronic chr17:27256399(-) A-I      intronic chr17:27250554(-) A-I      intronic chr17:27268798(-) A-I      intronic chr17:27270482(-) A-I      intronic chr17:27259218(-) A-I      intronic chr17:27271613(-) A-I      intronic chr17:27259343(-) A-I      intronic chr17:27260957(-) A-I      intronic chr17:27249300(-) A-I      intronic chr17:27258827(-) A-I      intronic chr17:27248397(-) A-I      intronic chr17:27249310(-) A-I      intronic chr17:27274044(-) A-I      intronic chr17:27274179(-) A-I      intronic chr17:27270572(-) A-I      intronic chr17:27260965(-) A-I      intronic chr17:27269350(-) A-I      intronic chr17:27272972(-) A-I      intronic chr17:27249358(-) A-I      intronic chr17:27274550(-) A-I      intronic chr17:27255951(-) A-I      intronic chr17:27241434(-) A-I      intronic chr17:27274113(-) A-I      intronic chr17:27270413(-) A-I      intronic chr17:27260900(-) A-I      intronic chr17:27249926(-) A-I      intronic chr17:27241643(-) A-I      intronic chr17:27246675(-) A-I      intronic chr17:27274180(-) A-I      intronic chr17:27243385(-) A-I      intronic chr17:27271634(-) A-I      intronic chr17:27274439(-) A-I      intronic chr17:27273806(-) A-I      intronic chr17:27273390(-) A-I      intronic chr17:27249968(-) A-I      intronic chr17:27274094(-) A-I      intronic chr17:27274064(-) A-I      intronic chr17:27249836(-) A-I      intronic chr17:27273764(-) A-I      intronic chr17:27249915(-) A-I      intronic chr17:27259431(-) A-I      intronic chr17:27259852(-) A-I      intronic chr17:27242901(-) A-I      intronic chr17:27246594(-) A-I      intronic chr17:27248287(-) A-I      intronic chr17:27256442(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PHF12	chr17:27274592(-) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PHF12	chr17:27232443-27232444(-) m6A 3'UTR       24981863//27773535 chr17:27232516-27232517(-) m6A 3'UTR       27773535 chr17:27232833-27232834(-) m6A 3'UTR       25456834//24981863//27773535 chr17:27232893-27232894(-) m6A 3'UTR       24209618//25456834//24981863//27773535//22575960 chr17:27232912-27232913(-) m6A 3'UTR       24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:27232925-27232926(-) m6A 3'UTR       24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:27232948-27232949(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:27232962-27232963(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:27233060-27233061(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr17:27233096-27233097(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr17:27233130-27233131(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:27233157-27233158(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr17:27233198-27233199(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr17:27233305-27233306(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//27773536//22575960 chr17:27233449-27233450(-) m6A 3'UTR//CDS       24284625//24981863//27371828 chr17:27233515-27233516(-) m6A 3'UTR//CDS       24284625//24981863//27371828 chr17:27233595-27233596(-) m6A 3'UTR//intron       - chr17:27233924-27233925(-) m6A 3'UTR//CDS       27773535 chr17:27233959-27233960(-) m6A 3'UTR//CDS       27773535 chr17:27233969-27233970(-) m6A 3'UTR//CDS       27773535 chr17:27233986-27233987(-) m6A 3'UTR//CDS       27773535 chr17:27234003-27234004(-) m6A 3'UTR//CDS       27773535 chr17:27234044-27234045(-) m6A 3'UTR//intron       27773535 chr17:27234116-27234117(-) m6A 3'UTR//intron       27773535 chr17:27234147-27234148(-) m6A 3'UTR//intron       27773535 chr17:27234200-27234201(-) m6A 3'UTR//intron       27773535 chr17:27234336-27234337(-) m6A 3'UTR//intron       27773535 chr17:27237279-27237280(-) m6A 3'UTR//CDS//exon       - chr17:27237735-27237736(-) m6A exon//intron       - chr17:27237755-27237756(-) m6A exon//intron       - chr17:27237761-27237762(-) m6A exon//intron       - chr17:27239635-27239636(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085 chr17:27239655-27239656(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085 chr17:27239678-27239679(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085 chr17:27239778-27239779(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr17:27239804-27239805(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr17:27239906-27239907(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr17:27239963-27239964(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr17:27239982-27239983(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr17:27239994-27239995(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr17:27240032-27240033(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr17:27240132-27240133(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr17:27240144-27240145(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr17:27240211-27240212(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:27240218-27240219(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:27240253-27240254(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:27240933-27240934(-) m6A 3'UTR//CDS//exon//intron       24284625 chr17:27244369-27244370(-) m6A 3'UTR//CDS//exon       27773535 chr17:27244378-27244379(-) m6A 3'UTR//CDS//exon       27773535 chr17:27244408-27244409(-) m6A 3'UTR//CDS//exon       27773535 chr17:27248772-27248773(-) m6A CDS//exon       24284625//24981863//27773535//27371828 chr17:27248796-27248797(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22608085 chr17:27250951-27250952(-) m6A CDS//exon//intron       24284625//24981863//27773535//27371828//22608085 chr17:27250979-27250980(-) m6A CDS//exon//intron       24284625//24981863//27773535//27371828//22608085 chr17:27251042-27251043(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr17:27251062-27251063(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr17:27251084-27251085(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:27251118-27251119(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:27251200-27251201(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr17:27251205-27251206(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr17:27251222-27251223(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr17:27251256-27251257(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr17:27251273-27251274(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr17:27251281-27251282(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr17:27251387-27251388(-) m6A exon//intron       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr17:27253985-27253986(-) m6A exon//intron       24284625//24981863//22608085 chr17:27255218-27255219(-) m6A 5'UTR//intron       24284625//24981863//22608085 chr17:27255245-27255246(-) m6A 5'UTR//intron       24284625 chr17:27276846-27276847(-) m6A 5'UTR//intron       27371828//27773536 chr17:27277314-27277315(-) m6A CDS//intron       24284625//27773535//27371828//27773536 chr17:27277335-27277336(-) m6A CDS//intron       27371828//27773536 chr17:27277368-27277369(-) m6A CDS//intron       - chr17:27277934-27277935(-) m6A CDS//exon//intron       27773536 chr17:27277959-27277960(-) m6A CDS//exon//intron       27371828//27773536 chr17:27278094-27278095(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//27773536 chr17:27278139-27278140(-) m6A 5'UTR//intron       25456834//27371828//27773536 chr17:27278194-27278195(-) m6A 5'UTR//intron       27371828//27773536 chr17:27278224-27278225(-) m6A 5'UTR//intron       27371828//27773536 chr17:27278260-27278261(-) m6A 5'UTR//intron       27371828//27773536 chr17:27278295-27278296(-) m6A 5'UTR//intron       24981863//27371828//27773536 chr17:27278414-27278415(-) m6A 5'UTR//intron       24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1294	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	PHF12	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1294
Interactor2: PHF12

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.