Basic Information:

  VIRBase ID:  

HHID00069644

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1294:  MIMAT0005884          ZBTB44:  NR_163264     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1294	ZBTB44
miRBase Accession/Entrez ID	MIMAT0005884	29068
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BTBD15//HSPC063//ZNF851

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1294	rs1162939290 chr5:154347163    G/T rs1179835339 chr5:154347171    G/GTATA rs1237976003 chr5:154347166    T/C rs1255234532 chr5:154347174    T/A rs1465013068 chr5:154347169    T/C rs189565536 chr5:154347168    G/T rs1211754242 chr5:154347158    G/A rs1341512450 chr5:154347155    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZBTB44	chr11:130132899(-) A-I      intronic chr11:130179758(-) A-I      intronic chr11:130177076(-) A-I      intronic chr11:130181218(-) A-I      intronic chr11:130155433(-) A-I      intronic chr11:130161119(-) A-I      intronic chr11:130161142(-) A-I      intronic chr11:130161237(-) A-I      intronic chr11:130168154(-) A-I      intronic chr11:130168234(-) A-I      intronic chr11:130168240(-) A-I      intronic chr11:130168972(-) A-I      intronic chr11:130171292(-) A-I      intronic chr11:130171451(-) A-I      intronic chr11:130172634(-) A-I      intronic chr11:130172758(-) A-I      intronic chr11:130173430(-) A-I      intronic chr11:130168193(-) A-I      intronic chr11:130173454(-) A-I      intronic chr11:130177196(-) A-I      intronic chr11:130177589(-) A-I      intronic chr11:130177595(-) A-I      intronic chr11:130177780(-) A-I      intronic chr11:130177814(-) A-I      intronic chr11:130177816(-) A-I      intronic chr11:130177820(-) A-I      intronic chr11:130177853(-) A-I      intronic chr11:130179675(-) A-I      intronic chr11:130179678(-) A-I      intronic chr11:130179757(-) A-I      intronic chr11:130180760(-) A-I      intronic chr11:130180770(-) A-I      intronic chr11:130181322(-) A-I      intronic chr11:130141940(-) A-I      intronic chr11:130153917(-) A-I      intronic chr11:130179753(-) A-I      intronic chr11:130132103(-) A-I      intronic chr11:130145651(-) A-I      intronic chr11:130132131(-) A-I      intronic chr11:130145605(-) A-I      intronic chr11:130168313(-) A-I      intronic chr11:130145788(-) A-I      intronic chr11:130180007(-) A-I      intronic chr11:130132942(-) A-I      intronic chr11:130181323(-) A-I      intronic chr11:130146397(-) A-I      intronic chr11:130168158(-) A-I      intronic chr11:130145341(-) A-I      intronic chr11:130179704(-) A-I      intronic chr11:130168964(-) A-I      intronic chr11:130143974(-) A-I      intronic chr11:130139072(-) A-I      intronic chr11:130146523(-) A-I      intronic chr11:130137096(-) A-I      intronic chr11:130143921(-) A-I      intronic chr11:130161304(-) A-I      intronic chr11:130146525(-) A-I      intronic chr11:130105859(-) A-I      intronic chr11:130110002(-) A-I      intronic chr11:130114369(-) A-I      intronic chr11:130114373(-) A-I      intronic chr11:130132120(-) A-I      intronic chr11:130132172(-) A-I      intronic chr11:130132238(-) A-I      intronic chr11:130132306(-) A-I      intronic chr11:130132307(-) A-I      intronic chr11:130132313(-) A-I      intronic chr11:130132856(-) A-I      intronic chr11:130137416(-) A-I      intronic chr11:130139062(-) A-I      intronic chr11:130139115(-) A-I      intronic chr11:130141869(-) A-I      intronic chr11:130141882(-) A-I      intronic chr11:130141900(-) A-I      intronic chr11:130142040(-) A-I      intronic chr11:130143372(-) A-I      intronic chr11:130143375(-) A-I      intronic chr11:130143401(-) A-I      intronic chr11:130143402(-) A-I      intronic chr11:130143426(-) A-I      intronic chr11:130143497(-) A-I      intronic chr11:130143691(-) A-I      intronic chr11:130143698(-) A-I      intronic chr11:130143839(-) A-I      intronic chr11:130143874(-) A-I      intronic chr11:130143920(-) A-I      intronic chr11:130143440(-) A-I      intronic chr11:130145690(-) A-I      intronic chr11:130145749(-) A-I      intronic chr11:130145896(-) A-I      intronic chr11:130145941(-) A-I      intronic chr11:130146087(-) A-I      intronic chr11:130146398(-) A-I      intronic chr11:130146406(-) A-I      intronic chr11:130146422(-) A-I      intronic chr11:130146440(-) A-I      intronic chr11:130146444(-) A-I      intronic chr11:130146591(-) A-I      intronic chr11:130146596(-) A-I      intronic chr11:130146613(-) A-I      intronic chr11:130151235(-) A-I      intronic chr11:130151270(-) A-I      intronic chr11:130151628(-) A-I      intronic chr11:130151685(-) A-I      intronic chr11:130151729(-) A-I      intronic chr11:130152821(-) A-I      intronic chr11:130152846(-) A-I      intronic chr11:130153924(-) A-I      intronic chr11:130154519(-) A-I      intronic chr11:130154529(-) A-I      intronic chr11:130177208(-) A-I      intronic chr11:130154599(-) A-I      intronic chr11:130154614(-) A-I      intronic chr11:130154654(-) A-I      intronic chr11:130154761(-) A-I      intronic chr11:130155289(-) A-I      intronic chr11:130155311(-) A-I      intronic chr11:130155324(-) A-I      intronic chr11:130143859(-) A-I      intronic chr11:130155365(-) A-I      intronic chr11:130155375(-) A-I      intronic chr11:130177759(-) A-I      intronic chr11:130155380(-) A-I      intronic chr11:130155381(-) A-I      intronic chr11:130155414(-) A-I      intronic chr11:130109719(-) A-I      NonSyn:Asp->Gly chr11:130132064(-) A-I      intronic chr11:130168238(-) A-I      intronic chr11:130143329(-) A-I      intronic chr11:130168237(-) A-I      intronic chr11:130179960(-) A-I      intronic chr11:130179705(-) A-I      intronic chr11:130143871(-) A-I      intronic chr11:130168866(-) A-I      intronic chr11:130168291(-) A-I      intronic chr11:130168081(-) A-I      intronic chr11:130181360(-) A-I      intronic chr11:130132861(-) A-I      intronic chr11:130139101(-) A-I      intronic chr11:130143883(-) A-I      intronic chr11:130155275(-) A-I      intronic chr11:130164141(-) A-I      intronic chr11:130151661(-) A-I      intronic chr11:130152832(-) A-I      intronic chr11:130168295(-) A-I      intronic chr11:130177785(-) A-I      intronic chr11:130151266(-) A-I      intronic chr11:130145933(-) A-I      intronic chr11:130168290(-) A-I      intronic chr11:130141875(-) A-I      intronic chr11:130168076(-) A-I      intronic chr11:130177138(-) A-I      intronic chr11:130143281(-) A-I      intronic chr11:130155315(-) A-I      intronic chr11:130151587(-) A-I      intronic chr11:130151586(-) A-I      intronic chr11:130177090(-) A-I      intronic chr11:130139068(-) A-I      intronic chr11:130180752(-) A-I      intronic chr11:130145793(-) A-I      intronic chr11:130138612(-) A-I      intronic chr11:130177211(-) A-I      intronic chr11:130145369(-) A-I      intronic chr11:130168869(-) A-I      intronic chr11:130137059(-) A-I      intronic chr11:130177063(-) A-I      intronic chr11:130181398(-) A-I      intronic chr11:130151601(-) A-I      intronic chr11:130143333(-) A-I      intronic chr11:130153949(-) A-I      intronic chr11:130153967(-) A-I      intronic chr11:130168153(-) A-I      intronic chr11:130145360(-) A-I      intronic chr11:130168162(-) A-I      intronic chr11:130137511(-) A-I      intronic chr11:130177276(-) A-I      intronic chr11:130143861(-) A-I      intronic chr11:130132880(-) A-I      intronic chr11:130151718(-) A-I      intronic chr11:130146512(-) A-I      intronic chr11:130145771(-) A-I      intronic chr11:130137123(-) A-I      intronic chr11:130137353(-) A-I      intronic chr11:130145687(-) A-I      intronic chr11:130141933(-) A-I      intronic chr11:130161305(-) A-I      intronic chr11:130151894(-) A-I      intronic chr11:130146458(-) A-I      intronic chr11:130181347(-) A-I      intronic chr11:130132834(-) A-I      intronic chr11:130145924(-) A-I      intronic chr11:130126498(-) A-I      intronic chr11:130177614(-) A-I      intronic chr11:130171691(-) A-I      intronic chr11:130153077(-) A-I      intronic chr11:130177825(-) A-I      intronic chr11:130145865(-) A-I      intronic chr11:130144062(-) A-I      intronic chr11:130180008(-) A-I      intronic chr11:130137393(-) A-I      intronic chr11:130137903(-) A-I      intronic chr11:130177198(-) A-I      intronic chr11:130141945(-) A-I      intronic chr11:130151734(-) A-I      intronic chr11:130137417(-) A-I      intronic chr11:130177075(-) A-I      intronic chr11:130145591(-) A-I      intronic chr11:130132227(-) A-I      intronic chr11:130132237(-) A-I      intronic chr11:130154678(-) A-I      intronic chr11:130154661(-) A-I      intronic chr11:130146526(-) A-I      intronic chr11:130154507(-) A-I      intronic chr11:130142091(-) A-I      intronic chr11:130154709(-) A-I      intronic chr11:130137379(-) A-I      intronic chr11:130137574(-) A-I      intronic chr11:130146197(-) A-I      intronic chr11:130168585(-) A-I      intronic chr11:130137589(-) A-I      intronic chr11:130138628(-) A-I      intronic chr11:130137580(-) A-I      intronic chr11:130151258(-) A-I      intronic chr11:130138605(-) A-I      intronic chr11:130180041(-) A-I      intronic chr11:130152994(-) A-I      intronic chr11:130177749(-) A-I      intronic chr11:130145794(-) A-I      intronic chr11:130168312(-) A-I      intronic chr11:130146470(-) A-I      intronic chr11:130177130(-) A-I      intronic chr11:130137159(-) A-I      intronic chr11:130146069(-) A-I      intronic chr11:130166011(-) A-I      intronic chr11:130145739(-) A-I      intronic chr11:130146074(-) A-I      intronic chr11:130168812(-) A-I      intronic chr11:130143343(-) A-I      intronic chr11:130143899(-) A-I      intronic chr11:130154596(-) A-I      intronic chr11:130168956(-) A-I      intronic chr11:130154649(-) A-I      intronic chr11:130153926(-) A-I      intronic chr11:130137082(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZBTB44	chr11:130109719(-) A-I exon CDS    19478186 chr11:130165965(-) A-I intron -    22327324 chr11:130166011(-) A-I intron -    22327324 chr11:130144062(-) A-G intron -    22484847 chr11:130146197(-) A-G intron -    22484847 chr11:130137082(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZBTB44	chr11:130101708-130101709(-) m6A 3'UTR//intron       27773535 chr11:130103176-130103177(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr11:130103628-130103629(-) m6A 3'UTR//intron       27773535 chr11:130103643-130103644(-) m6A 3'UTR//intron       27773535 chr11:130103654-130103655(-) m6A 3'UTR//intron       27773535 chr11:130103662-130103663(-) m6A 3'UTR//intron       27773535 chr11:130103668-130103669(-) m6A 3'UTR//intron       27773535 chr11:130104098-130104099(-) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:130104124-130104125(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr11:130104134-130104135(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr11:130104141-130104142(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr11:130104150-130104151(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr11:130106022-130106023(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr11:130106053-130106054(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr11:130106642-130106643(-) m6A exon//intron       24981863 chr11:130106654-130106655(-) m6A exon//intron       24981863 chr11:130106668-130106669(-) m6A exon//intron       24284625//24981863//22608085 chr11:130106702-130106703(-) m6A CDS//exon//intron       24284625//24981863//22608085 chr11:130106726-130106727(-) m6A CDS//exon//intron       24284625//24981863//22608085 chr11:130106784-130106785(-) m6A CDS//exon//intron       24981863//22608085 chr11:130106842-130106843(-) m6A CDS//exon//intron       22608085 chr11:130130782-130130783(-) m6A 3'UTR//CDS//exon       27773535//22608085 chr11:130130796-130130797(-) m6A 3'UTR//CDS//exon       27773535//22608085 chr11:130130813-130130814(-) m6A 3'UTR//CDS//exon       27773535//22608085 chr11:130130939-130130940(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:130130984-130130985(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:130131011-130131012(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:130131077-130131078(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr11:130131112-130131113(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr11:130131164-130131165(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085 chr11:130131251-130131252(-) m6A CDS//exon       24284625//24209618//24981863//27371828//22608085 chr11:130131336-130131337(-) m6A CDS//exon       24284625//24981863//26404942//22608085 chr11:130131565-130131566(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr11:130131591-130131592(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:130131652-130131653(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:130131684-130131685(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:130131755-130131756(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//22608085 chr11:130131822-130131823(-) m6A 5'UTR//exon       24284625//24209618//24981863//27371828//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1294	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	ZBTB44	Chromatin K562 cells     - Cytoplasm Cell line (HeLa)     22319583 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Cell line (HeLa)     22319583 Nucleus HeLa-S3 cells|K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1294
Interactor2: ZBTB44

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.