Detail Information

Basic Information:


  VIRBase ID:  

HHID00069642

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1294:           FBXO8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1294 FBXO8
miRBase
Accession/Entrez ID		 MIMAT0005884 26269
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DC10//FBS//FBX8

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1294
rs1162939290 chr5:154347163    G/T
rs1179835339 chr5:154347171    G/GTATA
rs1237976003 chr5:154347166    T/C
rs1255234532 chr5:154347174    T/A
rs1465013068 chr5:154347169    T/C
rs189565536 chr5:154347168    G/T
rs1211754242 chr5:154347158    G/A
rs1341512450 chr5:154347155    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FBXO8
chr4:175190828(-) A-I      intronic
chr4:175190817(-) A-I      intronic
chr4:175190792(-) A-I      intronic
chr4:175173212(-) A-I      intronic
chr4:175178987(-) A-I      intronic
chr4:175173248(-) A-I      intronic
chr4:175202744(-) A-I      intronic
chr4:175188684(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED FBXO8
chr4:175188684(-) A-G intron -    22484847
chr4:175190562(-) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FBXO8
chr4:175158389-175158390(-) m6A 3'UTR       27773535
chr4:175158508-175158509(-) m6A 3'UTR       24981863//27773535//22608085
chr4:175158525-175158526(-) m6A 3'UTR       24981863//22608085
chr4:175158544-175158545(-) m6A 3'UTR       24981863//22608085
chr4:175180931-175180932(-) m6A CDS       27773535
chr4:175183928-175183929(-) m6A CDS       27773535
chr4:175184051-175184052(-) m6A 5'UTR//CDS//intron       22608085
chr4:175184108-175184109(-) m6A 5'UTR//CDS       27773535//22608085
chr4:175184211-175184212(-) m6A 5'UTR//CDS       24981863//27773535//27773536
chr4:175190232-175190233(-) m6A 5'UTR//intron       27773535//27773536
chr4:175204691-175204692(-) m6A 5'UTR       24284625//24981863//22608085
chr4:175204874-175204875(-) m6A 5'UTR       24284625//24981863//22608085
chr4:175204899-175204900(-) m6A 5'UTR       24981863//22608085
chr4:175205017-175205018(-) m6A 5'UTR       24284625//24981863//22608085
chr4:175205084-175205085(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1294
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Serum     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
FBXO8
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1294
Interactor2: FBXO8

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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