Basic Information:

  VIRBase ID:  

HHID00069617

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1294:  MIMAT0005884          PMAIP1:  NM_001382623     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1294	PMAIP1
miRBase Accession/Entrez ID	MIMAT0005884	5366
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	APR//NOXA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1294	rs1162939290 chr5:154347163    G/T rs1179835339 chr5:154347171    G/GTATA rs1237976003 chr5:154347166    T/C rs1255234532 chr5:154347174    T/A rs1465013068 chr5:154347169    T/C rs189565536 chr5:154347168    G/T rs1211754242 chr5:154347158    G/A rs1341512450 chr5:154347155    T/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PMAIP1	chr18:57567196-57567197(+) m6A 5'UTR       25456834//24981863 chr18:57567277-57567278(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:57567307-57567308(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:57567421-57567422(+) m1A CDS//exon       26863410//26863196 chr18:57567689-57567690(+) m6A CDS//exon//intron       24284625//24209618//24981863//22608085 chr18:57567874-57567875(+) m6A exon//intron       - chr18:57567883-57567884(+) m6A exon//intron       24209618//25456834//24981863//22608085 chr18:57569920-57569921(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr18:57569929-57569930(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr18:57569942-57569943(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:57569963-57569964(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:57569979-57569980(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:57569996-57569997(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:57570010-57570011(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:57570064-57570065(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:57570189-57570190(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr18:57570199-57570200(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr18:57570232-57570233(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:57570350-57570351(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr18:57570369-57570370(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr18:57570480-57570481(+) m6A 3'UTR       24209618//27773535//22608085 chr18:57570493-57570494(+) m6A 3'UTR       24209618//27773535 chr18:57570631-57570632(+) m6A 3'UTR       24981863//27773535 chr18:57570641-57570642(+) m6A 3'UTR       24981863//27773535 chr18:57570709-57570710(+) m6A 3'UTR       24981863//27773535//22608085 chr18:57570714-57570715(+) m6A 3'UTR       24981863//27773535//22608085 chr18:57570734-57570735(+) m6A 3'UTR       24981863//27773535//22608085 chr18:57570805-57570806(+) m6A 3'UTR       22608085 chr18:57570815-57570816(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1294	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	PMAIP1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1294
Interactor2: PMAIP1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.