Basic Information:

  VIRBase ID:  

HHID00069614

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1294:  MIMAT0005884          OAS2:  NM_002535     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1294	OAS2
miRBase Accession/Entrez ID	MIMAT0005884	4939
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1294	rs1162939290 chr5:154347163    G/T rs1179835339 chr5:154347171    G/GTATA rs1237976003 chr5:154347166    T/C rs1255234532 chr5:154347174    T/A rs1465013068 chr5:154347169    T/C rs189565536 chr5:154347168    G/T rs1211754242 chr5:154347158    G/A rs1341512450 chr5:154347155    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OAS2	chr12:113439615(+) A-I      intronic chr12:113432356(+) A-I      intronic chr12:113432246(+) A-I      intronic chr12:113443749(+) A-I      intronic chr12:113437785(+) A-I      intronic chr12:113443267(+) A-I      intronic chr12:113440196(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OAS2	chr12:113416318-113416319(+) m6A 5'UTR       - chr12:113425228-113425229(+) m6A 3'UTR//intron       - chr12:113425235-113425236(+) m6A 3'UTR//intron       - chr12:113425268-113425269(+) m6A 3'UTR//intron       - chr12:113425287-113425288(+) m6A 3'UTR//intron       - chr12:113425392-113425393(+) m6A 3'UTR//intron       - chr12:113446941-113446942(+) m6A CDS       - chr12:113447012-113447013(+) m6A CDS       24981863 chr12:113447019-113447020(+) m6A CDS       24981863 chr12:113447107-113447108(+) m6A 3'UTR//intron       24981863 chr12:113447142-113447143(+) m6A 3'UTR//intron       24981863 chr12:113447157-113447158(+) m6A 3'UTR//intron       24981863 chr12:113447178-113447179(+) m6A 3'UTR//intron       24981863 chr12:113447330-113447331(+) m6A 3'UTR//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1294	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	OAS2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1294
Interactor2: OAS2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.