Basic Information:

  VIRBase ID:  

HHID00069599

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1294:  MIMAT0005884          CCND2:  NM_001759     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1294	CCND2
miRBase Accession/Entrez ID	MIMAT0005884	894
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAK0002//MPPH3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1294	rs1162939290 chr5:154347163    G/T rs1179835339 chr5:154347171    G/GTATA rs1237976003 chr5:154347166    T/C rs1255234532 chr5:154347174    T/A rs1465013068 chr5:154347169    T/C rs189565536 chr5:154347168    G/T rs1211754242 chr5:154347158    G/A rs1341512450 chr5:154347155    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCND2	chr12:4407683(+) A-I      intronic chr12:4406504(+) A-I      intronic chr12:4408273(+) A-I      intronic chr12:4408319(+) A-I      intronic chr12:4407661(+) A-I      intronic chr12:4408272(+) A-I      intronic chr12:4406535(+) A-I      intronic chr12:4408325(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCND2	chr12:4406341(+) A-T intron -    22484847 chr12:4406592(+) C-T intron -    22484847 chr12:4406734(+) C-T intron -    22484847 chr12:4406735(+) T-C intron -    22484847 chr12:4406736(+) C-A intron -    22484847 chr12:4407661(+) A-G intron -    22484847 chr12:4404682(+) T-C intron -    22484847 chr12:4408272(+) A-G intron -    22484847 chr12:4408273(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCND2	chr12:4382959-4382960(+) m6A 5'UTR       25456834//24981863 chr12:4382977-4382978(+) m6A 5'UTR       25456834//24981863 chr12:4383080-4383081(+) m6A 5'UTR       25456834//24981863 chr12:4383140-4383141(+) m6A 5'UTR       24981863 chr12:4383146-4383147(+) m6A 5'UTR       - chr12:4383154-4383155(+) m6A 5'UTR       - chr12:4409504-4409505(+) m6A 3'UTR       22608085 chr12:4409518-4409519(+) m6A 3'UTR       24981863//22608085 chr12:4409578-4409579(+) m6A 3'UTR       24209618//24981863//22608085 chr12:4409622-4409623(+) m6A 3'UTR       24209618//24981863//22608085 chr12:4409650-4409651(+) m6A 3'UTR       24209618//24981863//22608085 chr12:4409673-4409674(+) m6A 3'UTR       24209618//24981863//22608085 chr12:4409694-4409695(+) m6A 3'UTR       24209618//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1294	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	CCND2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1294
Interactor2: CCND2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.