Basic Information:

  VIRBase ID:  

HHID00069507

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548k:  MIMAT0005882          SH3BGRL:  NM_003022     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548k	SH3BGRL
miRBase Accession/Entrez ID	MIMAT0005882	6451
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HEL-S-115//SH3BGR

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548k	rs1287903682 chr11:70283986    A/T rs1348444734 chr11:70284001    T/G rs368851728 chr11:70283998    G/A rs549537039 chr11:70283997    C/A rs549537039 chr11:70283997    C/T rs759199954 chr11:70284000    A/G rs772907313 chr11:70283996    G/A rs1480700900 chr11:70283992    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SH3BGRL	chrX:80549337(+) A-I      intronic chrX:80549316(+) A-I      intronic chrX:80549315(+) A-I      intronic chrX:80549314(+) A-I      intronic chrX:80549313(+) A-I      intronic chrX:80549281(+) A-I      intronic chrX:80546755(+) A-I      intronic chrX:80546754(+) A-I      intronic chrX:80546723(+) A-I      intronic chrX:80546722(+) A-I      intronic chrX:80463492(+) A-I      intronic chrX:80463682(+) A-I      intronic chrX:80464526(+) A-I      intronic chrX:80464681(+) A-I      intronic chrX:80527575(+) A-I      intronic chrX:80527711(+) A-I      intronic chrX:80528205(+) A-I      intronic chrX:80530872(+) A-I      intronic chrX:80551160(+) A-I      intronic chrX:80551169(+) A-I      intronic chrX:80551166(+) A-I      intronic chrX:80551139(+) A-I      intronic chrX:80549340(+) A-I      intronic chrX:80549339(+) A-I      intronic chrX:80463500(+) A-I      intronic chrX:80464636(+) A-I      intronic chrX:80464633(+) A-I      intronic chrX:80527505(+) A-I      intronic chrX:80463501(+) A-I      intronic chrX:80463506(+) A-I      intronic chrX:80464781(+) A-I      intronic chrX:80463640(+) A-I      intronic chrX:80463570(+) A-I      intronic chrX:80464625(+) A-I      intronic chrX:80464600(+) A-I      intronic chrX:80464525(+) A-I      intronic chrX:80464607(+) A-I      intronic chrX:80464696(+) A-I      intronic chrX:80464704(+) A-I      intronic chrX:80463509(+) A-I      intronic chrX:80463576(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SH3BGRL	chrX:80546745(+) A-I intron -    21960545   //22327324 chrX:80551574(+) A-I intron -    22327324 chrX:80548711(+) A-I intron -    21960545 chrX:80551234(+) A-I intron -    21960545 chrX:80551481(+) A-I intron -    21960545 chrX:80546745(+) A-G intron -    22484847 chrX:80546746(+) A-G intron -    22484847 chrX:80546969(+) A-G intron -    22484847 chrX:80551001(+) A-G intron -    22484847 chrX:80551481(+) A-G intron -    22484847 chrX:80551574(+) A-G intron -    22484847 chrX:80463762(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SH3BGRL	chrX:80457478-80457479(+) m6A 5'UTR       24981863 chrX:80457510-80457511(+) m6A 5'UTR       24981863 chrX:80457669-80457670(+) m6A 5'UTR//exon       24981863 chrX:80457675-80457676(+) m6A 5'UTR//exon       24981863 chrX:80552859-80552860(+) m6A 3'UTR//exon       24981863//26404942 chrX:80552891-80552892(+) m6A 3'UTR//exon       24981863//26404942 chrX:80553804-80553805(+) m6A 3'UTR       26404942 chrX:80553816-80553817(+) m6A 3'UTR       26404942 chrX:80553823-80553824(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548k	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	SH3BGRL	Chromatin K562 cells     - Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548k
Interactor2: SH3BGRL

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.