Basic Information:

  VIRBase ID:  

HHID00069453

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1287-5p:  MIMAT0005878          YTHDC2:  NM_022828     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1287-5p	YTHDC2
miRBase Accession/Entrez ID	MIMAT0005878	64848
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAHL//hYTHDC2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1287-5p	rs1035954011 chr10:98395283    T/C rs1217917543 chr10:98395280    C/T rs200279130 chr10:98395276    G/A rs200279130 chr10:98395276    G/C rs752651721 chr10:98395275    C/T rs747124418 chr10:98395291    C/G rs764565318 chr10:98395288    C/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	YTHDC2	chr5:112853806(+) A-I      intronic chr5:112853719(+) A-I      intronic chr5:112853715(+) A-I      intronic chr5:112857241(+) A-I      intronic chr5:112857285(+) A-I      intronic chr5:112857353(+) A-I      intronic chr5:112925335(+) A-I      intronic chr5:112925399(+) A-I      intronic chr5:112925374(+) A-I      intronic chr5:112925370(+) A-I      intronic chr5:112925203(+) A-I      intronic chr5:112894540(+) A-I      intronic chr5:112864489(+) A-I      intronic chr5:112854002(+) A-I      intronic chr5:112857317(+) A-I      intronic chr5:112924459(+) A-I      intronic chr5:112854137(+) A-I      intronic chr5:112925381(+) A-I      intronic chr5:112894539(+) A-I      intronic chr5:112857266(+) A-I      intronic chr5:112854164(+) A-I      intronic chr5:112854138(+) A-I      intronic chr5:112854133(+) A-I      intronic chr5:112925262(+) A-I      intronic chr5:112925368(+) A-I      intronic chr5:112925267(+) A-I      intronic chr5:112857173(+) A-I      intronic chr5:112893282(+) A-I      intronic chr5:112924561(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	YTHDC2	chr5:112853991(+) A-G intron -    22484847 chr5:112854133(+) A-G intron -    22484847 chr5:112854134(+) A-G intron -    22484847 chr5:112854137(+) A-G intron -    22484847 chr5:112854138(+) A-G intron -    22484847 chr5:112857251(+) A-G intron -    22484847 chr5:112906050(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	YTHDC2	chr5:112860827-112860828(+) m6A CDS//intron       24981863 chr5:112927754-112927755(+) m6A CDS//exon       24981863 chr5:112929007-112929008(+) m6A CDS//exon       22608085 chr5:112929022-112929023(+) m6A CDS//exon       22608085 chr5:112929066-112929067(+) m6A CDS//exon       24284625//24981863//22608085 chr5:112929136-112929137(+) m6A exon//intron       24284625//24981863//22608085 chr5:112929179-112929180(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929197-112929198(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929241-112929242(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929301-112929302(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929542-112929543(+) m6A 3'UTR//exon       24981863//22608085 chr5:112929593-112929594(+) m6A 3'UTR//exon       24981863//22608085 chr5:112929630-112929631(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:112929642-112929643(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:112929655-112929656(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:112929737-112929738(+) m6A 3'UTR//exon       27773535 chr5:112930025-112930026(+) m6A 3'UTR//exon       24981863 chr5:112930042-112930043(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1287-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	YTHDC2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1287-5p
Interactor2: YTHDC2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.