Basic Information:

  VIRBase ID:  

HHID00069369

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548j-5p:  MIMAT0005875          ZFYVE21:  NM_001198953     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548j-5p	ZFYVE21
miRBase Accession/Entrez ID	MIMAT0005875	79038
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCVP7TP1//ZF21

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548j-5p	rs1210209539 chr22:26555275    C/T rs545900525 chr22:26555280    G/C rs565141718 chr22:26555283    C/A rs565141718 chr22:26555283    C/G rs565141718 chr22:26555283    C/T rs751780445 chr22:26555284    G/A rs753744163 chr22:26555282    C/A rs757533254 chr22:26555285    C/A rs367750295 chr22:26555290    A/G rs976434292 chr22:26555292    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZFYVE21	chr14:104185726(+) A-I      intronic chr14:104189052(+) A-I      intronic chr14:104188778(+) A-I      intronic chr14:104188792(+) A-I      intronic chr14:104188893(+) A-I      intronic chr14:104188973(+) A-I      intronic chr14:104185721(+) A-I      intronic chr14:104193483(+) A-I      intronic chr14:104185650(+) A-I      intronic chr14:104185713(+) A-I      intronic chr14:104193492(+) A-I      intronic chr14:104185741(+) A-I      intronic chr14:104193480(+) A-I      intronic chr14:104189097(+) A-I      intronic chr14:104197432(+) A-I      intronic chr14:104188901(+) A-I      intronic chr14:104189035(+) A-I      intronic chr14:104189176(+) A-I      intronic chr14:104189261(+) A-I      intronic chr14:104188818(+) A-I      intronic chr14:104187260(+) A-I      intronic chr14:104188759(+) A-I      intronic chr14:104187183(+) A-I      intronic chr14:104187259(+) A-I      intronic chr14:104188831(+) A-I      intronic chr14:104185780(+) A-I      intronic chr14:104187277(+) A-I      intronic chr14:104188748(+) A-I      intronic chr14:104189101(+) A-I      intronic chr14:104197437(+) A-I      intronic chr14:104188902(+) A-I      intronic chr14:104188821(+) A-I      intronic chr14:104185686(+) A-I      intronic chr14:104188715(+) A-I      intronic chr14:104185494(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZFYVE21	chr14:104197572(+) A-I intron -    21960545 chr14:104197527(+) G-A intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZFYVE21	chr14:104191030-104191031(+) m6A exon//intron       - chr14:104199347-104199348(+) m6A CDS//exon       24981863 chr14:104199396-104199397(+) m6A 3'UTR//exon       24981863 chr14:104199411-104199412(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548j-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ZFYVE21	Chromatin K562 cells     - Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548j-5p
Interactor2: ZFYVE21

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.