Basic Information:

  VIRBase ID:  

HHID00068874

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320c:  MIMAT0005793          RNF138:  NM_016271     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320c	RNF138
miRBase Accession/Entrez ID	MIMAT0005793	51444
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	hNARF//HSD-4//NARF//STRIN

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320c	rs1240746422 chr18:21683578    T/TAAAA rs1280160499 chr18:21683572    A/G rs1443511707 chr18:21683574    AGGGT/A rs772189670 chr18:21683576    G/T rs778052898 chr18:21683578    T/C rs1285199699 chr18:24321732    G/A rs1285199699 chr18:24321732    G/C rs748073401 chr18:24321734    G/A rs756244906 chr18:24321728    G/A rs769415707 chr18:24321724    G/C rs769415707 chr18:24321724    G/T rs780317956 chr18:24321733    G/A rs958657957 chr18:24321725    G/A rs991776304 chr18:24321726    T/C rs1344472820 chr18:21683563    G/A rs748166297 chr18:21683564    C/G rs751288880 chr18:21683557    GGAAAA/G rs1159517960 chr18:24321717    A/G rs1327994455 chr18:24321720    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RNF138	chr18:29700386(+) A-I      intronic chr18:29700956(+) A-I      intronic chr18:29701023(+) A-I      intronic chr18:29698418(+) A-I      intronic chr18:29700380(+) A-I      intronic chr18:29700396(+) A-I      intronic chr18:29677686(+) A-I      intronic chr18:29701007(+) A-I      intronic chr18:29700399(+) A-I      intronic chr18:29700434(+) A-I      intronic chr18:29700987(+) A-I      intronic chr18:29700975(+) A-I      intronic chr18:29690145(+) A-I      intronic chr18:29701936(+) A-I      intronic chr18:29701949(+) A-I      intronic chr18:29702032(+) A-I      intronic chr18:29677688(+) A-I      intronic chr18:29677720(+) A-I      intronic chr18:29677721(+) A-I      intronic chr18:29678131(+) A-I      intronic chr18:29678649(+) A-I      intronic chr18:29679551(+) A-I      intronic chr18:29679603(+) A-I      intronic chr18:29679604(+) A-I      intronic chr18:29682657(+) A-I      intronic chr18:29682713(+) A-I      intronic chr18:29682855(+) A-I      intronic chr18:29682856(+) A-I      intronic chr18:29683672(+) A-I      intronic chr18:29683808(+) A-I      intronic chr18:29683818(+) A-I      intronic chr18:29689141(+) A-I      intronic chr18:29686718(+) A-I      intronic chr18:29686716(+) A-I      intronic chr18:29684250(+) A-I      intronic chr18:29684118(+) A-I      intronic chr18:29684051(+) A-I      intronic chr18:29683996(+) A-I      intronic chr18:29702525(+) A-I      intronic chr18:29701181(+) A-I      intronic chr18:29702082(+) A-I      intronic chr18:29700941(+) A-I      intronic chr18:29700913(+) A-I      intronic chr18:29699457(+) A-I      intronic chr18:29699419(+) A-I      intronic chr18:29699418(+) A-I      intronic chr18:29699411(+) A-I      intronic chr18:29702531(+) A-I      intronic chr18:29699407(+) A-I      intronic chr18:29698698(+) A-I      intronic chr18:29702707(+) A-I      intronic chr18:29702712(+) A-I      intronic chr18:29703709(+) A-I      intronic chr18:29703850(+) A-I      intronic chr18:29703854(+) A-I      intronic chr18:29703855(+) A-I      intronic chr18:29698688(+) A-I      intronic chr18:29698671(+) A-I      intronic chr18:29698336(+) A-I      intronic chr18:29698283(+) A-I      intronic chr18:29698272(+) A-I      intronic chr18:29697108(+) A-I      intronic chr18:29684116(+) A-I      intronic chr18:29697099(+) A-I      intronic chr18:29696958(+) A-I      intronic chr18:29692616(+) A-I      intronic chr18:29701275(+) A-I      intronic chr18:29701279(+) A-I      intronic chr18:29701901(+) A-I      intronic chr18:29684238(+) A-I      intronic chr18:29692528(+) A-I      intronic chr18:29692527(+) A-I      intronic chr18:29692525(+) A-I      intronic chr18:29692416(+) A-I      intronic chr18:29689777(+) A-I      intronic chr18:29689728(+) A-I      intronic chr18:29689703(+) A-I      intronic chr18:29689679(+) A-I      intronic chr18:29689672(+) A-I      intronic chr18:29689664(+) A-I      intronic chr18:29689580(+) A-I      intronic chr18:29689358(+) A-I      intronic chr18:29689246(+) A-I      intronic chr18:29689186(+) A-I      intronic chr18:29689178(+) A-I      intronic chr18:29689148(+) A-I      intronic chr18:29701337(+) A-I      intronic chr18:29701942(+) A-I      intronic chr18:29689661(+) A-I      intronic chr18:29701297(+) A-I      intronic chr18:29698227(+) A-I      intronic chr18:29679637(+) A-I      intronic chr18:29702667(+) A-I      intronic chr18:29689299(+) A-I      intronic chr18:29701301(+) A-I      intronic chr18:29689420(+) A-I      intronic chr18:29702611(+) A-I      intronic chr18:29698713(+) A-I      intronic chr18:29701294(+) A-I      intronic chr18:29700938(+) A-I      intronic chr18:29689799(+) A-I      intronic chr18:29689755(+) A-I      intronic chr18:29695610(+) A-I      intronic chr18:29683671(+) A-I      intronic chr18:29701298(+) A-I      intronic chr18:29696614(+) A-I      intronic chr18:29702509(+) A-I      intronic chr18:29698264(+) A-I      intronic chr18:29698538(+) A-I      intronic chr18:29695619(+) A-I      intronic chr18:29697139(+) A-I      intronic chr18:29677586(+) A-I      intronic chr18:29695633(+) A-I      intronic chr18:29690027(+) A-I      intronic chr18:29678050(+) A-I      intronic chr18:29681863(+) A-I      intronic chr18:29699487(+) A-I      intronic chr18:29689806(+) A-I      intronic chr18:29708704(+) A-I      intronic chr18:29693223(+) A-I      intronic chr18:29700873(+) A-I      intronic chr18:29678295(+) A-I      intronic chr18:29678638(+) A-I      intronic chr18:29695653(+) A-I      intronic chr18:29692566(+) A-I      intronic chr18:29695663(+) A-I      intronic chr18:29689764(+) A-I      intronic chr18:29678134(+) A-I      intronic chr18:29689505(+) A-I      intronic chr18:29689191(+) A-I      intronic chr18:29685235(+) A-I      intronic chr18:29699570(+) A-I      intronic chr18:29697087(+) A-I      intronic chr18:29700977(+) A-I      intronic chr18:29702676(+) A-I      intronic chr18:29697004(+) A-I      intronic chr18:29691005(+) A-I      intronic chr18:29689801(+) A-I      intronic chr18:29688761(+) A-I      intronic chr18:29689596(+) A-I      intronic chr18:29699516(+) A-I      intronic chr18:29678658(+) A-I      intronic chr18:29701013(+) A-I      intronic chr18:29676783(+) A-I      intronic chr18:29697039(+) A-I      intronic chr18:29695446(+) A-I      intronic chr18:29702104(+) A-I      intronic chr18:29706103(+) A-I      intronic chr18:29688913(+) A-I      intronic chr18:29702092(+) A-I      intronic chr18:29699325(+) A-I      intronic chr18:29684173(+) A-I      intronic chr18:29690191(+) A-I      intronic chr18:29698733(+) A-I      intronic chr18:29678067(+) A-I      intronic chr18:29707789(+) A-I      intronic chr18:29678237(+) A-I      intronic chr18:29689738(+) A-I      intronic chr18:29701973(+) A-I      intronic chr18:29701040(+) A-I      intronic chr18:29686709(+) A-I      intronic chr18:29699597(+) A-I      intronic chr18:29698258(+) A-I      intronic chr18:29678075(+) A-I      intronic chr18:29686694(+) A-I      intronic chr18:29701303(+) A-I      intronic chr18:29678151(+) A-I      intronic chr18:29707788(+) A-I      intronic chr18:29701441(+) A-I      intronic chr18:29696648(+) A-I      intronic chr18:29689700(+) A-I      intronic chr18:29701971(+) A-I      intronic chr18:29678089(+) A-I      intronic chr18:29700939(+) A-I      intronic chr18:29701403(+) A-I      intronic chr18:29701282(+) A-I      intronic chr18:29676769(+) A-I      intronic chr18:29702006(+) A-I      intronic chr18:29683916(+) A-I      intronic chr18:29692544(+) A-I      intronic chr18:29678230(+) A-I      intronic chr18:29698243(+) A-I      intronic chr18:29702015(+) A-I      intronic chr18:29684104(+) A-I      intronic chr18:29699444(+) A-I      intronic chr18:29689426(+) A-I      intronic chr18:29696615(+) A-I      intronic chr18:29701373(+) A-I      intronic chr18:29686693(+) A-I      intronic chr18:29701351(+) A-I      intronic chr18:29701300(+) A-I      intronic chr18:29697048(+) A-I      intronic chr18:29701931(+) A-I      intronic chr18:29700940(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RNF138	chr18:29700377(+) A-I intron -    22327324 chr18:29701942(+) A-I intron -    22327324 chr18:29700007(+) A-I intron -    21960545 chr18:29700014(+) A-I intron -    21960545 chr18:29700042(+) A-I intron -    21960545 chr18:29684173(+) A-G intron -    22484847 chr18:29701931(+) A-G intron -    22484847 chr18:29701942(+) A-G intron -    22484847 chr18:29702015(+) A-G intron -    22484847 chr18:29700377(+) A-G intron -    22484847 chr18:29700381(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RNF138	chr18:29671970-29671971(+) m6A 5'UTR//exon       24981863 chr18:29672107-29672108(+) m6A 5'UTR//exon       - chr18:29672147-29672148(+) m6A 5'UTR//exon       - chr18:29672749-29672750(+) m6A CDS//exon//intron       - chr18:29691826-29691827(+) m6A CDS//exon//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320c	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Ovarian follicular fluid     22116803 Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Serum     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	RNF138	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320c
Interactor2: RNF138

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.