Detail Information

Basic Information:


  VIRBase ID:  

HHID00068873

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320c:           CD274:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-320c CD274
miRBase
Accession/Entrez ID		 MIMAT0005793 29126
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - B7-H//B7H1//hPD-L1//PD-L1//PDCD1L1//PDCD1LG1//PDL1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-320c
rs1240746422 chr18:21683578    T/TAAAA
rs1280160499 chr18:21683572    A/G
rs1443511707 chr18:21683574    AGGGT/A
rs772189670 chr18:21683576    G/T
rs778052898 chr18:21683578    T/C
rs1285199699 chr18:24321732    G/A
rs1285199699 chr18:24321732    G/C
rs748073401 chr18:24321734    G/A
rs756244906 chr18:24321728    G/A
rs769415707 chr18:24321724    G/C
rs769415707 chr18:24321724    G/T
rs780317956 chr18:24321733    G/A
rs958657957 chr18:24321725    G/A
rs991776304 chr18:24321726    T/C
rs1344472820 chr18:21683563    G/A
rs748166297 chr18:21683564    C/G
rs751288880 chr18:21683557    GGAAAA/G
rs1159517960 chr18:24321717    A/G
rs1327994455 chr18:24321720    G/A

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CD274
chr9:5457102-5457103(+) m6A CDS//exon//intron       24981863
chr9:5457163-5457164(+) m6A CDS//exon//intron       24981863
chr9:5457171-5457172(+) m6A CDS//exon//intron       24981863
chr9:5457213-5457214(+) m6A CDS//exon//intron       24981863
chr9:5457243-5457244(+) m6A CDS//exon//intron       24981863
chr9:5457271-5457272(+) m6A CDS//exon//intron       24981863
chr9:5457294-5457295(+) m6A CDS//exon//intron       24981863
chr9:5462940-5462941(+) m6A CDS//exon       24981863
chr9:5462973-5462974(+) m6A CDS//exon//intron       24981863
chr9:5466811-5466812(+) m6A CDS//exon       24981863
chr9:5467874-5467875(+) m6A 3'UTR       24981863
chr9:5467979-5467980(+) m6A 3'UTR       24981863
chr9:5468008-5468009(+) m6A 3'UTR       24981863
chr9:5468052-5468053(+) m6A 3'UTR       24981863
chr9:5468071-5468072(+) m6A 3'UTR       24981863
chr9:5468138-5468139(+) m6A 3'UTR       24981863
chr9:5468294-5468295(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-320c
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Ovarian follicular fluid     22116803
Exosome Plasma     23663360
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
CD274
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-320c
Interactor2: CD274

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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