Basic Information:

  VIRBase ID:  

HHID00068872

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320c:  MIMAT0005793          ARFIP1:  NM_001025595     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320c	ARFIP1
miRBase Accession/Entrez ID	MIMAT0005793	27236
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSU52521

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320c	rs1240746422 chr18:21683578    T/TAAAA rs1280160499 chr18:21683572    A/G rs1443511707 chr18:21683574    AGGGT/A rs772189670 chr18:21683576    G/T rs778052898 chr18:21683578    T/C rs1285199699 chr18:24321732    G/A rs1285199699 chr18:24321732    G/C rs748073401 chr18:24321734    G/A rs756244906 chr18:24321728    G/A rs769415707 chr18:24321724    G/C rs769415707 chr18:24321724    G/T rs780317956 chr18:24321733    G/A rs958657957 chr18:24321725    G/A rs991776304 chr18:24321726    T/C rs1344472820 chr18:21683563    G/A rs748166297 chr18:21683564    C/G rs751288880 chr18:21683557    GGAAAA/G rs1159517960 chr18:24321717    A/G rs1327994455 chr18:24321720    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARFIP1	chr4:153816903(+) A-I      intronic chr4:153710302(+) A-I      intronic chr4:153826914(+) A-I      intronic chr4:153711979(+) A-I      intronic chr4:153826926(+) A-I      intronic chr4:153826939(+) A-I      intronic chr4:153830438(+) A-I      intronic chr4:153830524(+) A-I      intronic chr4:153779248(+) A-I      intronic chr4:153710274(+) A-I      intronic chr4:153710266(+) A-I      intronic chr4:153735718(+) A-I      intronic chr4:153704406(+) A-I      intronic chr4:153709673(+) A-I      intronic chr4:153710262(+) A-I      intronic chr4:153709742(+) A-I      intronic chr4:153728015(+) A-I      intronic chr4:153728009(+) A-I      intronic chr4:153728030(+) A-I      intronic chr4:153730124(+) A-I      intronic chr4:153710504(+) A-I      intronic chr4:153710342(+) A-I      intronic chr4:153730161(+) A-I      intronic chr4:153731821(+) A-I      intronic chr4:153731853(+) A-I      intronic chr4:153733464(+) A-I      intronic chr4:153735448(+) A-I      intronic chr4:153735606(+) A-I      intronic chr4:153735711(+) A-I      intronic chr4:153745367(+) A-I      intronic chr4:153780434(+) A-I      intronic chr4:153780448(+) A-I      intronic chr4:153815368(+) A-I      intronic chr4:153816799(+) A-I      intronic chr4:153816806(+) A-I      intronic chr4:153816852(+) A-I      intronic chr4:153816854(+) A-I      intronic chr4:153702481(+) A-I      intronic chr4:153735480(+) A-I      intronic chr4:153704339(+) A-I      intronic chr4:153779224(+) A-I      intronic chr4:153780428(+) A-I      intronic chr4:153735408(+) A-I      intronic chr4:153735607(+) A-I      intronic chr4:153731847(+) A-I      intronic chr4:153780449(+) A-I      intronic chr4:153710343(+) A-I      intronic chr4:153709670(+) A-I      intronic chr4:153825528(+) A-I      intronic chr4:153813294(+) A-I      intronic chr4:153735775(+) A-I      intronic chr4:153812999(+) A-I      intronic chr4:153735701(+) A-I      intronic chr4:153728042(+) A-I      intronic chr4:153733480(+) A-I      intronic chr4:153710423(+) A-I      intronic chr4:153779285(+) A-I      intronic chr4:153780293(+) A-I      intronic chr4:153709753(+) A-I      intronic chr4:153702569(+) A-I      intronic chr4:153733476(+) A-I      intronic chr4:153730191(+) A-I      intronic chr4:153780313(+) A-I      intronic chr4:153709294(+) A-I      intronic chr4:153733486(+) A-I      intronic chr4:153702572(+) A-I      intronic chr4:153780435(+) A-I      intronic chr4:153735297(+) A-I      intronic chr4:153735508(+) A-I      intronic chr4:153709667(+) A-I      intronic chr4:153830273(+) A-I      intronic chr4:153735311(+) A-I      intronic chr4:153779243(+) A-I      intronic chr4:153709274(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ARFIP1	chr4:153726958(+) A-G intron -    22484847 chr4:153754647(+) A-G intron -    22484847 chr4:153754743(+) A-G intron -    22484847 chr4:153767305(+) T-C intron -    22484847 chr4:153702379(+) C-T intron -    22484847 chr4:153702481(+) A-G intron -    22484847 chr4:153702569(+) A-G intron -    22484847 chr4:153702572(+) A-G intron -    22484847 chr4:153709622(+) A-G intron -    22484847 chr4:153709667(+) A-G intron -    22484847 chr4:153709670(+) A-G intron -    22484847 chr4:153709671(+) A-G intron -    22484847 chr4:153709674(+) A-G intron -    22484847 chr4:153709753(+) A-G intron -    22484847 chr4:153710343(+) A-G intron -    22484847 chr4:153710423(+) A-G intron -    22484847 chr4:153731847(+) A-G intron -    22484847 chr4:153733476(+) A-G intron -    22484847 chr4:153733480(+) A-G intron -    22484847 chr4:153733486(+) A-G intron -    22484847 chr4:153735254(+) T-C intron -    22484847 chr4:153735404(+) A-G intron -    22484847 chr4:153735408(+) A-G intron -    22484847 chr4:153735480(+) A-G intron -    22484847 chr4:153735508(+) A-G intron -    22484847 chr4:153735607(+) A-G intron -    22484847 chr4:153735648(+) A-G intron -    22484847 chr4:153735701(+) A-G intron -    22484847 chr4:153735712(+) A-G intron -    22484847 chr4:153735775(+) A-G intron -    22484847 chr4:153779224(+) A-G intron -    22484847 chr4:153780428(+) A-G intron -    22484847 chr4:153780449(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARFIP1	chr4:153701263-153701264(+) m1A 5'UTR//exon//intron       26863196 chr4:153809320-153809321(+) m6A CDS//exon       24981863 chr4:153809332-153809333(+) m6A CDS//exon       24981863 chr4:153809346-153809347(+) m6A CDS//exon       24981863 chr4:153831295-153831296(+) m6A CDS//exon       24981863//27773535//22608085 chr4:153831307-153831308(+) m6A CDS//exon       24981863//27773535//22608085 chr4:153831329-153831330(+) m6A CDS//exon       24981863//27773535//22608085 chr4:153831364-153831365(+) m6A CDS//exon       24981863//27773535//22608085 chr4:153831417-153831418(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr4:153831491-153831492(+) m6A 3'UTR//exon       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320c	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Ovarian follicular fluid     22116803 Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Serum     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	ARFIP1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320c
Interactor2: ARFIP1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.