Basic Information:

  VIRBase ID:  

HHID00068805

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320b:  MIMAT0005792          SIK1:  NM_173354     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320b	SIK1
miRBase Accession/Entrez ID	MIMAT0005792	150094
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DEE30//MSK//SIK//SIK-1//SIK1B//SNF1LK

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320b	rs1156276707 chr1:116671796    G/T rs1311857670 chr1:116671805    GCAAA/G rs1373244526 chr1:116671806    C/T rs1434535374 chr1:116671803    G/C rs755613466 chr1:116671797    T/C rs779451916 chr1:116671801    G/C rs1303311077 chr1:224257059    A/T rs1313950455 chr1:224257062    C/A rs1333032274 chr1:224257051    G/T rs1445839645 chr1:224257055    T/C rs1465806287 chr1:224257050    TGCCC/T rs745315768 chr1:224257052    C/T rs769446888 chr1:224257054    C/T rs1189118293 chr1:116671788    A/G rs1199375375 chr1:116671794    G/A rs1411861918 chr1:116671791    G/T rs1469116635 chr1:116671792    C/CTGGGTTGAGAGGGCAAACAAATTAACTAAT rs1030808536 chr1:224257064    A/T rs774951709 chr1:224257069    T/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SIK1	chr21:44834548-44834549(-) m6A 3'UTR       26404942 chr21:44834808-44834809(-) m6A 3'UTR       26404942 chr21:44834876-44834877(-) m6A 3'UTR       24284625//26404942//27773535 chr21:44834932-44834933(-) m6A 3'UTR       24284625//26404942//27773535 chr21:44834956-44834957(-) m6A 3'UTR       24284625//26404942//27773535//22575960 chr21:44834984-44834985(-) m6A 3'UTR       24284625//26404942//27773535//22575960 chr21:44835195-44835196(-) m6A 3'UTR       24284625//26404942 chr21:44835210-44835211(-) m6A 3'UTR       24284625//26404942 chr21:44835248-44835249(-) m6A 3'UTR       24284625 chr21:44835330-44835331(-) m6A 3'UTR       22575960 chr21:44835676-44835677(-) m6A 3'UTR       26404942 chr21:44835730-44835731(-) m6A 3'UTR       26404942 chr21:44835793-44835794(-) m6A 3'UTR       26404942//22575960 chr21:44835924-44835925(-) m6A 3'UTR       26404942//27371828//22575960 chr21:44835962-44835963(-) m6A 3'UTR       26404942//27371828//22575960 chr21:44835987-44835988(-) m6A 3'UTR       26404942//27371828 chr21:44836012-44836013(-) m6A 3'UTR       26404942 chr21:44836048-44836049(-) m6A 3'UTR       26404942 chr21:44836057-44836058(-) m6A 3'UTR       26404942 chr21:44836141-44836142(-) m6A 3'UTR       26404942 chr21:44836148-44836149(-) m6A 3'UTR       26404942 chr21:44836356-44836357(-) m6A 3'UTR       24284625//24209618//26404942//27773535 chr21:44836413-44836414(-) Am 3'UTR       - chr21:44836425-44836426(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535 chr21:44836432-44836433(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535 chr21:44836535-44836536(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr21:44836557-44836558(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr21:44836596-44836597(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr21:44836664-44836665(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr21:44836679-44836680(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr21:44836787-44836788(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr21:44836827-44836828(-) m6A CDS       24284625//24209618//24981863//27371828//22575960 chr21:44837590-44837591(-) m6A CDS       24284625//25456834//24981863//26404942//27371828//27773536//22575960 chr21:44837595-44837596(-) m6A CDS       24284625//25456834//24981863//26404942//27371828//27773536//22575960 chr21:44837612-44837613(-) m6A CDS       24284625//24981863//26404942//27371828//27773536//22575960 chr21:44837621-44837622(-) m6A CDS       24284625//24981863//26404942//27371828//27773536//22575960 chr21:44838156-44838157(-) m6A CDS       24284625//24981863//27371828//27773536//22575960 chr21:44838376-44838377(-) m6A CDS       24284625 chr21:44838986-44838987(-) m6A CDS       24284625//26404942//22575960 chr21:44839040-44839041(-) m6A CDS       24284625//22575960 chr21:44839260-44839261(-) m6A CDS       24284625//22575960 chr21:44839294-44839295(-) m6A CDS       24284625//22575960 chr21:44839754-44839755(-) m6A CDS       24284625//22575960 chr21:44840132-44840133(-) m6A CDS       24284625//26404942 chr21:44840145-44840146(-) m6A CDS       24284625//26404942 chr21:44840227-44840228(-) m6A CDS       24284625 chr21:44840300-44840301(-) m6A CDS       24284625 chr21:44840938-44840939(-) m6A CDS       24284625//22575960 chr21:44841224-44841225(-) Cm CDS//exon       - chr21:44845964-44845965(-) m6A CDS       22575960 chr21:44846029-44846030(-) m6A CDS       24284625//24209618//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320b	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Ovarian follicular fluid     22116803 Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Hepatoma cells     23771658 Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	SIK1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320b	Eloxatine 5310940 Drug interaction    RC00007663 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007662 Benzene 241 Drug interaction    RC00007661 Marine fungal metabolite 1386A - Drug interaction    RC00007664

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320b	Topotecan       60700

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320b
Interactor2: SIK1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.