Basic Information:

  VIRBase ID:  

HHID00068775

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320b:  MIMAT0005792          ANGEL1:  NM_001370747     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320b	ANGEL1
miRBase Accession/Entrez ID	MIMAT0005792	23357
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Ccr4e//KIAA0759

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320b	rs1156276707 chr1:116671796    G/T rs1311857670 chr1:116671805    GCAAA/G rs1373244526 chr1:116671806    C/T rs1434535374 chr1:116671803    G/C rs755613466 chr1:116671797    T/C rs779451916 chr1:116671801    G/C rs1303311077 chr1:224257059    A/T rs1313950455 chr1:224257062    C/A rs1333032274 chr1:224257051    G/T rs1445839645 chr1:224257055    T/C rs1465806287 chr1:224257050    TGCCC/T rs745315768 chr1:224257052    C/T rs769446888 chr1:224257054    C/T rs1189118293 chr1:116671788    A/G rs1199375375 chr1:116671794    G/A rs1411861918 chr1:116671791    G/T rs1469116635 chr1:116671792    C/CTGGGTTGAGAGGGCAAACAAATTAACTAAT rs1030808536 chr1:224257064    A/T rs774951709 chr1:224257069    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ANGEL1	chr14:77272215(-) A-I      intronic chr14:77272205(-) A-I      intronic chr14:77272174(-) A-I      intronic chr14:77272221(-) A-I      intronic chr14:77272230(-) A-I      intronic chr14:77262759(-) A-I      intronic chr14:77271592(-) A-I      intronic chr14:77262703(-) A-I      intronic chr14:77262739(-) A-I      intronic chr14:77262668(-) A-I      intronic chr14:77262681(-) A-I      intronic chr14:77262702(-) A-I      intronic chr14:77271583(-) A-I      intronic chr14:77271588(-) A-I      intronic chr14:77265099(-) A-I      intronic chr14:77265816(-) A-I      intronic chr14:77265909(-) A-I      intronic chr14:77265111(-) A-I      intronic chr14:77263861(-) A-I      intronic chr14:77265179(-) A-I      intronic chr14:77264671(-) A-I      intronic chr14:77263750(-) A-I      intronic chr14:77265205(-) A-I      intronic chr14:77262816(-) A-I      intronic chr14:77267055(-) A-I      intronic chr14:77267110(-) A-I      intronic chr14:77262889(-) A-I      intronic chr14:77267736(-) A-I      intronic chr14:77268255(-) A-I      intronic chr14:77263762(-) A-I      intronic chr14:77266098(-) A-I      intronic chr14:77265775(-) A-I      intronic chr14:77266147(-) A-I      intronic chr14:77264677(-) A-I      intronic chr14:77265072(-) A-I      intronic chr14:77268249(-) A-I      intronic chr14:77267546(-) A-I      intronic chr14:77265734(-) A-I      intronic chr14:77267131(-) A-I      intronic chr14:77267142(-) A-I      intronic chr14:77262652(-) A-I      intronic chr14:77262675(-) A-I      intronic chr14:77262695(-) A-I      intronic chr14:77267167(-) A-I      intronic chr14:77266119(-) A-I      intronic chr14:77266004(-) A-I      intronic chr14:77262700(-) A-I      intronic chr14:77262701(-) A-I      intronic chr14:77262707(-) A-I      intronic chr14:77265748(-) A-I      intronic chr14:77267168(-) A-I      intronic chr14:77262723(-) A-I      intronic chr14:77262803(-) A-I      intronic chr14:77262871(-) A-I      intronic chr14:77265670(-) A-I      intronic chr14:77265733(-) A-I      intronic chr14:77265699(-) A-I      intronic chr14:77267489(-) A-I      intronic chr14:77265684(-) A-I      intronic chr14:77260951(-) A-I      intronic chr14:77265839(-) A-I      intronic chr14:77265801(-) A-I      intronic chr14:77265667(-) A-I      intronic chr14:77262870(-) A-I      intronic chr14:77262767(-) A-I      intronic chr14:77272210(-) A-I      intronic chr14:77264749(-) A-I      intronic chr14:77263770(-) A-I      intronic chr14:77262812(-) A-I      intronic chr14:77267730(-) A-I      intronic chr14:77264761(-) A-I      intronic chr14:77262844(-) A-I      intronic chr14:77271618(-) A-I      intronic chr14:77268295(-) A-I      intronic chr14:77264743(-) A-I      intronic chr14:77266171(-) A-I      intronic chr14:77271539(-) A-I      intronic chr14:77265903(-) A-I      intronic chr14:77272001(-) A-I      intronic chr14:77272145(-) A-I      intronic chr14:77262764(-) A-I      intronic chr14:77262795(-) A-I      intronic chr14:77267564(-) A-I      intronic chr14:77266152(-) A-I      intronic chr14:77262745(-) A-I      intronic chr14:77262635(-) A-I      intronic chr14:77264546(-) A-I      intronic chr14:77264632(-) A-I      intronic chr14:77264669(-) A-I      intronic chr14:77262879(-) A-I      intronic chr14:77266934(-) A-I      intronic chr14:77264557(-) A-I      intronic chr14:77265204(-) A-I      intronic chr14:77272217(-) A-I      intronic chr14:77272229(-) A-I      intronic chr14:77267253(-) A-I      intronic chr14:77262694(-) A-I      intronic chr14:77266146(-) A-I      intronic chr14:77271573(-) A-I      intronic chr14:77262731(-) A-I      intronic chr14:77262729(-) A-I      intronic chr14:77267069(-) A-I      intronic chr14:77271638(-) A-I      intronic chr14:77267734(-) A-I      intronic chr14:77264592(-) A-I      intronic chr14:77264596(-) A-I      intronic chr14:77267655(-) A-I      intronic chr14:77265998(-) A-I      intronic chr14:77262708(-) A-I      intronic chr14:77266205(-) A-I      intronic chr14:77272216(-) A-I      intronic chr14:77262676(-) A-I      intronic chr14:77262689(-) A-I      intronic chr14:77267624(-) A-I      intronic chr14:77265815(-) A-I      intronic chr14:77260770(-) A-I      intronic chr14:77265143(-) A-I      intronic chr14:77268343(-) A-I      intronic chr14:77265992(-) A-I      intronic chr14:77264606(-) A-I      intronic chr14:77271634(-) A-I      intronic chr14:77264726(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ANGEL1	chr14:77265903(-) A-G intron -    22484847 chr14:77265909(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ANGEL1	chr14:77252720-77252721(-) m6A 3'UTR       24981863//22608085 chr14:77252810-77252811(-) m6A 3'UTR       24981863 chr14:77254365-77254366(-) m6A 3'UTR       27773535 chr14:77254370-77254371(-) m6A 3'UTR       27773535 chr14:77254397-77254398(-) m6A 3'UTR       27773535 chr14:77254421-77254422(-) m6A 3'UTR       27773535 chr14:77255422-77255423(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr14:77255472-77255473(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr14:77255487-77255488(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr14:77255515-77255516(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr14:77255619-77255620(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr14:77255707-77255708(-) m6A CDS       27773535 chr14:77256956-77256957(-) m6A CDS       27773535 chr14:77256961-77256962(-) m6A CDS       27773535 chr14:77269802-77269803(-) m6A 5'UTR//CDS       27371828//27773536 chr14:77270238-77270239(-) m6A 5'UTR//CDS       - chr14:77270246-77270247(-) m6A 5'UTR//CDS       - chr14:77272840-77272841(-) m6A 5'UTR//CDS       24284625//25456834//24981863//22608085 chr14:77272881-77272882(-) m6A CDS       24284625//25456834//24981863//22608085 chr14:77272894-77272895(-) m6A CDS       24284625//25456834//24981863//22608085 chr14:77272968-77272969(-) Y CDS       26075521 chr14:77275520-77275521(-) m6A CDS       24284625//24981863//27371828//22608085 chr14:77275571-77275572(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr14:77275685-77275686(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr14:77275730-77275731(-) m6A CDS//exon       24284625//25456834//24981863//27371828//27773536//22608085 chr14:77275795-77275796(-) m6A CDS//exon       24284625//25456834//24981863//27371828//22608085 chr14:77275946-77275947(-) m6A 5'UTR//CDS//exon       24284625 chr14:77279216-77279217(-) m6A 5'UTR//intron       24981863 chr14:77279249-77279250(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320b	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Ovarian follicular fluid     22116803 Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Hepatoma cells     23771658 Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	ANGEL1	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320b	Eloxatine 5310940 Drug interaction    RC00007663 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007662 Benzene 241 Drug interaction    RC00007661 Marine fungal metabolite 1386A - Drug interaction    RC00007664

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320b	Topotecan       60700

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320b
Interactor2: ANGEL1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.