Basic Information:

  VIRBase ID:  

HHID00068763

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320b:  MIMAT0005792          ZFYVE16:  NR_146173     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320b	ZFYVE16
miRBase Accession/Entrez ID	MIMAT0005792	9765
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PPP1R69

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320b	rs1156276707 chr1:116671796    G/T rs1311857670 chr1:116671805    GCAAA/G rs1373244526 chr1:116671806    C/T rs1434535374 chr1:116671803    G/C rs755613466 chr1:116671797    T/C rs779451916 chr1:116671801    G/C rs1303311077 chr1:224257059    A/T rs1313950455 chr1:224257062    C/A rs1333032274 chr1:224257051    G/T rs1445839645 chr1:224257055    T/C rs1465806287 chr1:224257050    TGCCC/T rs745315768 chr1:224257052    C/T rs769446888 chr1:224257054    C/T rs1189118293 chr1:116671788    A/G rs1199375375 chr1:116671794    G/A rs1411861918 chr1:116671791    G/T rs1469116635 chr1:116671792    C/CTGGGTTGAGAGGGCAAACAAATTAACTAAT rs1030808536 chr1:224257064    A/T rs774951709 chr1:224257069    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZFYVE16	chr5:79763654(+) A-I      intronic chr5:79763639(+) A-I      intronic chr5:79763634(+) A-I      intronic chr5:79763632(+) A-I      intronic chr5:79762321(+) A-I      intronic chr5:79762334(+) A-I      intronic chr5:79763665(+) A-I      intronic chr5:79763625(+) A-I      intronic chr5:79763619(+) A-I      intronic chr5:79763612(+) A-I      intronic chr5:79763611(+) A-I      intronic chr5:79763610(+) A-I      intronic chr5:79763675(+) A-I      intronic chr5:79763674(+) A-I      intronic chr5:79763670(+) A-I      intronic chr5:79763669(+) A-I      intronic chr5:79763667(+) A-I      intronic chr5:79763659(+) A-I      intronic chr5:79763656(+) A-I      intronic chr5:79763655(+) A-I      intronic chr5:79763607(+) A-I      intronic chr5:79763603(+) A-I      intronic chr5:79763602(+) A-I      intronic chr5:79763592(+) A-I      intronic chr5:79762404(+) A-I      intronic chr5:79763589(+) A-I      intronic chr5:79763587(+) A-I      intronic chr5:79762372(+) A-I      intronic chr5:79762368(+) A-I      intronic chr5:79762367(+) A-I      intronic chr5:79762359(+) A-I      intronic chr5:79762349(+) A-I      intronic chr5:79762306(+) A-I      intronic chr5:79708730(+) A-I      intronic chr5:79708738(+) A-I      intronic chr5:79708744(+) A-I      intronic chr5:79708755(+) A-I      intronic chr5:79708761(+) A-I      intronic chr5:79708765(+) A-I      intronic chr5:79762340(+) A-I      intronic chr5:79708884(+) A-I      intronic chr5:79708891(+) A-I      intronic chr5:79715387(+) A-I      intronic chr5:79719539(+) A-I      intronic chr5:79743027(+) A-I      intronic chr5:79741815(+) A-I      intronic chr5:79706649(+) A-I      intronic chr5:79723740(+) A-I      intronic chr5:79741844(+) A-I      intronic chr5:79706529(+) A-I      intronic chr5:79706519(+) A-I      intronic chr5:79742927(+) A-I      intronic chr5:79742936(+) A-I      intronic chr5:79743018(+) A-I      intronic chr5:79743046(+) A-I      intronic chr5:79754886(+) A-I      intronic chr5:79754961(+) A-I      intronic chr5:79755009(+) A-I      intronic chr5:79765055(+) A-I      intronic chr5:79765061(+) A-I      intronic chr5:79765067(+) A-I      intronic chr5:79765985(+) A-I      intronic chr5:79766127(+) A-I      intronic chr5:79708864(+) A-I      intronic chr5:79741466(+) A-I      intronic chr5:79753698(+) A-I      intronic chr5:79708812(+) A-I      intronic chr5:79741912(+) A-I      intronic chr5:79771902(+) A-I      intronic chr5:79706887(+) A-I      intronic chr5:79753591(+) A-I      intronic chr5:79708934(+) A-I      intronic chr5:79754880(+) A-I      intronic chr5:79741990(+) A-I      intronic chr5:79741650(+) A-I      intronic chr5:79742825(+) A-I      intronic chr5:79742826(+) A-I      intronic chr5:79765297(+) A-I      intronic chr5:79771866(+) A-I      intronic chr5:79741950(+) A-I      intronic chr5:79741977(+) A-I      intronic chr5:79741459(+) A-I      intronic chr5:79709179(+) A-I      intronic chr5:79742890(+) A-I      intronic chr5:79743047(+) A-I      intronic chr5:79708966(+) A-I      intronic chr5:79741935(+) A-I      intronic chr5:79743007(+) A-I      intronic chr5:79742972(+) A-I      intronic chr5:79709143(+) A-I      intronic chr5:79741860(+) A-I      intronic chr5:79707801(+) A-I      intronic chr5:79772243(+) A-I      intronic chr5:79741519(+) A-I      intronic chr5:79737992(+) A-I      intronic chr5:79741954(+) A-I      intronic chr5:79742944(+) A-I      intronic chr5:79743006(+) A-I      intronic chr5:79709027(+) A-I      intronic chr5:79731264(+) A-I      intronic chr5:79709295(+) A-I      intronic chr5:79741898(+) A-I      intronic chr5:79741609(+) A-I      intronic chr5:79741595(+) A-I      intronic chr5:79757619(+) A-I      intronic chr5:79742962(+) A-I      intronic chr5:79742871(+) A-I      intronic chr5:79755008(+) A-I      intronic chr5:79741506(+) A-I      intronic chr5:79743001(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZFYVE16	chr5:79745469(+) A-I exon CDS    15342557 chr5:79748004(+) A-I intron -    15342557 chr5:79748029(+) A-I intron -    15342557 chr5:79748067(+) A-I intron -    15342557 chr5:79748068(+) A-I intron -    15342557 chr5:79748076(+) A-I intron -    15342557 chr5:79748078(+) A-I intron -    15342557 chr5:79748107(+) A-I intron -    15342557 chr5:79748123(+) A-I intron -    15342557 chr5:79748133(+) A-I intron -    15342557 chr5:79748147(+) A-I intron -    15342557 chr5:79748169(+) A-I intron -    15342557 chr5:79748179(+) A-I intron -    15342557 chr5:79748240(+) A-I intron -    15342557 chr5:79750406(+) A-I intron -    15342557 chr5:79750430(+) A-I intron -    15342557 chr5:79750443(+) A-I intron -    15342557 chr5:79750511(+) A-I intron -    15342557 chr5:79750520(+) A-I intron -    15342557 chr5:79750536(+) A-I intron -    15342557 chr5:79750540(+) A-I intron -    15342557 chr5:79750591(+) A-I intron -    15342557 chr5:79751157(+) A-I intron -    15342557 chr5:79751166(+) A-I intron -    15342557 chr5:79751167(+) A-I intron -    15342557 chr5:79751177(+) A-I intron -    15342557 chr5:79751206(+) A-I intron -    15342557 chr5:79751230(+) A-I intron -    15342557 chr5:79751232(+) A-I intron -    15342557 chr5:79751233(+) A-I intron -    15342557 chr5:79751278(+) A-I intron -    15342557 chr5:79751282(+) A-I intron -    15342557 chr5:79751295(+) A-I intron -    15342557 chr5:79751310(+) A-I intron -    15342557 chr5:79751332(+) A-I intron -    15342557 chr5:79774171(+) A-I exon 3'UTR    15342557 chr5:79750410(+) T-C intron -    21725310 chr5:79706975(+) G-T intron -    22484847 chr5:79709027(+) A-G intron -    22484847 chr5:79741860(+) A-G intron -    22484847 chr5:79741898(+) A-G intron -    22484847 chr5:79741912(+) A-G intron -    22484847 chr5:79741924(+) A-G intron -    22484847 chr5:79741935(+) A-G intron -    22484847 chr5:79741949(+) A-G intron -    22484847 chr5:79741950(+) A-G intron -    22484847 chr5:79742825(+) A-G intron -    22484847 chr5:79742879(+) A-G intron -    22484847 chr5:79742890(+) A-G intron -    22484847 chr5:79743011(+) A-G intron -    22484847 chr5:79750511(+) A-G intron -    22484847 chr5:79750536(+) A-G intron -    22484847 chr5:79751166(+) A-G intron -    22484847 chr5:79751167(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZFYVE16	chr5:79703891-79703892(+) m6A 5'UTR//exon       24981863 chr5:79705529-79705530(+) m6A exon//intron       24981863 chr5:79705542-79705543(+) m6A exon//intron       24981863 chr5:79732578-79732579(+) m6A 5'UTR//CDS//exon       24284625 chr5:79732660-79732661(+) m6A 5'UTR//CDS//exon       24284625//24981863//22608085 chr5:79732679-79732680(+) m6A 5'UTR//CDS//exon       24284625//24981863//22608085 chr5:79732714-79732715(+) m6A 5'UTR//CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:79732726-79732727(+) m6A 5'UTR//CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085 chr5:79732753-79732754(+) m6A 5'UTR//CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085 chr5:79732764-79732765(+) m6A 5'UTR//CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085 chr5:79732800-79732801(+) m6A 5'UTR//CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085 chr5:79732875-79732876(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:79733039-79733040(+) m6A CDS//exon       24981863//27773535//22575960//22608085 chr5:79733064-79733065(+) m6A CDS//exon       24981863//27773535//22608085 chr5:79733173-79733174(+) m6A CDS//exon       24981863//27773535//22608085 chr5:79733282-79733283(+) m6A CDS//exon       24981863//22608085 chr5:79733398-79733399(+) m6A CDS//exon       24981863//26404942//22608085 chr5:79733509-79733510(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr5:79733520-79733521(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr5:79733537-79733538(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr5:79733552-79733553(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr5:79733709-79733710(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr5:79733759-79733760(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr5:79733781-79733782(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr5:79733808-79733809(+) m6A CDS//exon       24284625//24981863//22608085 chr5:79733861-79733862(+) m6A CDS//exon       24284625//22608085 chr5:79733884-79733885(+) m6A CDS//exon       24284625//22608085 chr5:79734038-79734039(+) m6A CDS//exon       24981863//26404942//22608085 chr5:79734099-79734100(+) m6A CDS//exon       24981863//22608085 chr5:79734120-79734121(+) m6A CDS//exon       24981863//22608085 chr5:79734133-79734134(+) m6A CDS//exon       24981863//27773535//22608085 chr5:79734221-79734222(+) m6A CDS//exon       24981863//27773535//22608085 chr5:79734306-79734307(+) m6A CDS//exon       26404942//27773535//22608085 chr5:79734447-79734448(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:79734478-79734479(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:79734494-79734495(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr5:79734534-79734535(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr5:79734689-79734690(+) m6A CDS//exon       24981863//22608085 chr5:79734723-79734724(+) m6A CDS//exon       24981863//26404942//22608085 chr5:79734758-79734759(+) m6A CDS//exon       24981863//26404942//22608085 chr5:79734767-79734768(+) m6A CDS//exon       24981863//26404942//22608085 chr5:79768608-79768609(+) m6A CDS//exon//intron       24981863 chr5:79768640-79768641(+) m6A CDS//exon//intron       24981863 chr5:79768648-79768649(+) m6A CDS//exon//intron       24981863 chr5:79768684-79768685(+) m6A CDS//exon//intron       24981863 chr5:79774562-79774563(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:79774598-79774599(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:79774629-79774630(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:79774676-79774677(+) m6A 3'UTR//exon       24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320b	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Ovarian follicular fluid     22116803 Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Hepatoma cells     23771658 Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	ZFYVE16	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320b	Eloxatine 5310940 Drug interaction    RC00007663 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007662 Benzene 241 Drug interaction    RC00007661 Marine fungal metabolite 1386A - Drug interaction    RC00007664

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320b	Topotecan       60700

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320b
Interactor2: ZFYVE16

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.