Basic Information:

  VIRBase ID:  

HHID00068749

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320b:  MIMAT0005792          SLC5A3:  NM_006933     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320b	SLC5A3
miRBase Accession/Entrez ID	MIMAT0005792	6526
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BCW2//SMIT//SMIT1//SMIT2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320b	rs1156276707 chr1:116671796    G/T rs1311857670 chr1:116671805    GCAAA/G rs1373244526 chr1:116671806    C/T rs1434535374 chr1:116671803    G/C rs755613466 chr1:116671797    T/C rs779451916 chr1:116671801    G/C rs1303311077 chr1:224257059    A/T rs1313950455 chr1:224257062    C/A rs1333032274 chr1:224257051    G/T rs1445839645 chr1:224257055    T/C rs1465806287 chr1:224257050    TGCCC/T rs745315768 chr1:224257052    C/T rs769446888 chr1:224257054    C/T rs1189118293 chr1:116671788    A/G rs1199375375 chr1:116671794    G/A rs1411861918 chr1:116671791    G/T rs1469116635 chr1:116671792    C/CTGGGTTGAGAGGGCAAACAAATTAACTAAT rs1030808536 chr1:224257064    A/T rs774951709 chr1:224257069    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC5A3	chr21:35477030(+) A-I      3'UTR chr21:35458140(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC5A3	chr21:35445872-35445873(+) m6A 5'UTR       - chr21:35445960-35445961(+) m6A 5'UTR       22575960 chr21:35467185-35467186(+) m6A 5'UTR       - chr21:35467304-35467305(+) m6A 5'UTR       24284625//24981863//26404942//22575960//22608085 chr21:35467344-35467345(+) m6A 5'UTR       24284625//25456834//24981863//22575960//22608085 chr21:35467351-35467352(+) m6A 5'UTR       24284625//25456834//24981863//22575960//22608085 chr21:35467359-35467360(+) m6A 5'UTR       24284625//25456834//24981863//22575960//22608085 chr21:35467365-35467366(+) m6A 5'UTR       24284625//25456834//24981863//22575960//22608085 chr21:35467418-35467419(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr21:35467455-35467456(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr21:35467513-35467514(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr21:35467522-35467523(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr21:35468050-35468051(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr21:35468301-35468302(+) m6A CDS       24981863//22608085 chr21:35468368-35468369(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr21:35468635-35468636(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr21:35468684-35468685(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr21:35468897-35468898(+) m6A CDS       24284625//24209618//22575960//22608085 chr21:35469019-35469020(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr21:35469065-35469066(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr21:35469113-35469114(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr21:35469123-35469124(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr21:35469148-35469149(+) m6A CDS       24284625//24981863//26404942//22575960//22608085 chr21:35469166-35469167(+) m6A CDS       24284625//24981863//26404942//22575960//22608085 chr21:35469185-35469186(+) m6A CDS       24284625//24981863//26404942//22608085 chr21:35469237-35469238(+) m6A CDS       24284625//24981863//22608085 chr21:35469274-35469275(+) m6A CDS       24284625//24981863//22575960//22608085 chr21:35469372-35469373(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr21:35469472-35469473(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr21:35469523-35469524(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr21:35469567-35469568(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr21:35469599-35469600(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr21:35469654-35469655(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr21:35469672-35469673(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr21:35469685-35469686(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr21:35469800-35469801(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr21:35469854-35469855(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr21:35469863-35469864(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr21:35469914-35469915(+) m6A 3'UTR       24284625//24981863//22608085 chr21:35470004-35470005(+) m6A 3'UTR       24284625//22608085 chr21:35470083-35470084(+) m6A 3'UTR       24284625//22608085 chr21:35470096-35470097(+) m6A 3'UTR       24284625//22608085 chr21:35470156-35470157(+) m6A 3'UTR       22608085 chr21:35470275-35470276(+) m6A 3'UTR       22608085 chr21:35472620-35472621(+) m6A 3'UTR       - chr21:35472679-35472680(+) m6A 3'UTR       - chr21:35472918-35472919(+) Y 3'UTR       26075521 chr21:35476957-35476958(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320b	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Ovarian follicular fluid     22116803 Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Hepatoma cells     23771658 Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	SLC5A3	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320b	Eloxatine 5310940 Drug interaction    RC00007663 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007662 Benzene 241 Drug interaction    RC00007661 Marine fungal metabolite 1386A - Drug interaction    RC00007664

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320b	Topotecan       60700

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320b
Interactor2: SLC5A3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.