Basic Information:

  VIRBase ID:  

HHID00068747

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320b:  MIMAT0005792          RGS10:  NM_001005339     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320b	RGS10
miRBase Accession/Entrez ID	MIMAT0005792	6001
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320b	rs1156276707 chr1:116671796    G/T rs1311857670 chr1:116671805    GCAAA/G rs1373244526 chr1:116671806    C/T rs1434535374 chr1:116671803    G/C rs755613466 chr1:116671797    T/C rs779451916 chr1:116671801    G/C rs1303311077 chr1:224257059    A/T rs1313950455 chr1:224257062    C/A rs1333032274 chr1:224257051    G/T rs1445839645 chr1:224257055    T/C rs1465806287 chr1:224257050    TGCCC/T rs745315768 chr1:224257052    C/T rs769446888 chr1:224257054    C/T rs1189118293 chr1:116671788    A/G rs1199375375 chr1:116671794    G/A rs1411861918 chr1:116671791    G/T rs1469116635 chr1:116671792    C/CTGGGTTGAGAGGGCAAACAAATTAACTAAT rs1030808536 chr1:224257064    A/T rs774951709 chr1:224257069    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RGS10	chr10:121288222(-) A-I      intronic chr10:121288224(-) A-I      intronic chr10:121278355(-) A-I      intronic chr10:121278381(-) A-I      intronic chr10:121274052(-) A-I      intronic chr10:121287610(-) A-I      intronic chr10:121282517(-) A-I      intronic chr10:121268518(-) A-I      intronic chr10:121288201(-) A-I      intronic chr10:121288237(-) A-I      intronic chr10:121274083(-) A-I      intronic chr10:121273944(-) A-I      intronic chr10:121282014(-) A-I      intronic chr10:121287722(-) A-I      intronic chr10:121273787(-) A-I      intronic chr10:121274094(-) A-I      intronic chr10:121273978(-) A-I      intronic chr10:121273987(-) A-I      intronic chr10:121274046(-) A-I      intronic chr10:121287600(-) A-I      intronic chr10:121266381(-) A-I      intronic chr10:121273786(-) A-I      intronic chr10:121287739(-) A-I      intronic chr10:121278331(-) A-I      intronic chr10:121273747(-) A-I      intronic chr10:121272188(-) A-I      intronic chr10:121268933(-) A-I      intronic chr10:121278313(-) A-I      intronic chr10:121271095(-) A-I      intronic chr10:121266377(-) A-I      intronic chr10:121263839(-) A-I      intronic chr10:121272915(-) A-I      intronic chr10:121262833(-) A-I      intronic chr10:121283170(-) A-I      intronic chr10:121272197(-) A-I      intronic chr10:121278345(-) A-I      intronic chr10:121273952(-) A-I      intronic chr10:121278464(-) A-I      intronic chr10:121272220(-) A-I      intronic chr10:121283171(-) A-I      intronic chr10:121272235(-) A-I      intronic chr10:121282985(-) A-I      intronic chr10:121281006(-) A-I      intronic chr10:121288714(-) A-I      intronic chr10:121282933(-) A-I      intronic chr10:121272890(-) A-I      intronic chr10:121272237(-) A-I      intronic chr10:121274007(-) A-I      intronic chr10:121281043(-) A-I      intronic chr10:121282959(-) A-I      intronic chr10:121282932(-) A-I      intronic chr10:121269067(-) A-I      intronic chr10:121270328(-) A-I      intronic chr10:121262800(-) A-I      intronic chr10:121274113(-) A-I      intronic chr10:121272248(-) A-I      intronic chr10:121289518(-) A-I      intronic chr10:121273990(-) A-I      intronic chr10:121270414(-) A-I      intronic chr10:121268994(-) A-I      intronic chr10:121266416(-) A-I      intronic chr10:121262696(-) A-I      intronic chr10:121282012(-) A-I      intronic chr10:121282581(-) A-I      intronic chr10:121288730(-) A-I      intronic chr10:121287680(-) A-I      intronic chr10:121270913(-) A-I      intronic chr10:121272333(-) A-I      intronic chr10:121288857(-) A-I      intronic chr10:121271084(-) A-I      intronic chr10:121263816(-) A-I      intronic chr10:121282506(-) A-I      intronic chr10:121272200(-) A-I      intronic chr10:121282474(-) A-I      intronic chr10:121268485(-) A-I      intronic chr10:121272233(-) A-I      intronic chr10:121288189(-) A-I      intronic chr10:121289541(-) A-I      intronic chr10:121288183(-) A-I      intronic chr10:121271036(-) A-I      intronic chr10:121288111(-) A-I      intronic chr10:121266406(-) A-I      intronic chr10:121268417(-) A-I      intronic chr10:121287769(-) A-I      intronic chr10:121299877(-) A-I      intronic chr10:121299901(-) A-I      intronic chr10:121272877(-) A-I      intronic chr10:121266395(-) A-I      intronic chr10:121274048(-) A-I      intronic chr10:121280987(-) A-I      intronic chr10:121272341(-) A-I      intronic chr10:121272349(-) A-I      intronic chr10:121272889(-) A-I      intronic chr10:121287736(-) A-I      intronic chr10:121287710(-) A-I      intronic chr10:121287635(-) A-I      intronic chr10:121273788(-) A-I      intronic chr10:121287632(-) A-I      intronic chr10:121287615(-) A-I      intronic chr10:121288208(-) A-I      intronic chr10:121273913(-) A-I      intronic chr10:121289384(-) A-I      intronic chr10:121274087(-) A-I      intronic chr10:121280638(-) A-I      intronic chr10:121287816(-) A-I      intronic chr10:121288126(-) A-I      intronic chr10:121282975(-) A-I      intronic chr10:121270886(-) A-I      intronic chr10:121299887(-) A-I      intronic chr10:121287628(-) A-I      intronic chr10:121282960(-) A-I      intronic chr10:121282602(-) A-I      intronic chr10:121283095(-) A-I      intronic chr10:121288935(-) A-I      intronic chr10:121282425(-) A-I      intronic chr10:121270320(-) A-I      intronic chr10:121273953(-) A-I      intronic chr10:121272259(-) A-I      intronic chr10:121288127(-) A-I      intronic chr10:121273904(-) A-I      intronic chr10:121289552(-) A-I      intronic chr10:121280774(-) A-I      intronic chr10:121262627(-) A-I      intronic chr10:121271069(-) A-I      intronic chr10:121273998(-) A-I      intronic chr10:121288337(-) A-I      intronic chr10:121287681(-) A-I      intronic chr10:121267347(-) A-I      intronic chr10:121282491(-) A-I      intronic chr10:121268692(-) A-I      intronic chr10:121282513(-) A-I      intronic chr10:121283055(-) A-I      intronic chr10:121272292(-) A-I      intronic chr10:121272311(-) A-I      intronic chr10:121287683(-) A-I      intronic chr10:121270883(-) A-I      intronic chr10:121269020(-) A-I      intronic chr10:121299830(-) A-I      intronic chr10:121272158(-) A-I      intronic chr10:121267706(-) A-I      intronic chr10:121268653(-) A-I      intronic chr10:121287721(-) A-I      intronic chr10:121272310(-) A-I      intronic chr10:121293645(-) A-I      intronic chr10:121278490(-) A-I      intronic chr10:121272332(-) A-I      intronic chr10:121269101(-) A-I      intronic chr10:121282423(-) A-I      intronic chr10:121280776(-) A-I      intronic chr10:121289557(-) A-I      intronic chr10:121288191(-) A-I      intronic chr10:121274058(-) A-I      intronic chr10:121299841(-) A-I      intronic chr10:121274088(-) A-I      intronic chr10:121267784(-) A-I      intronic chr10:121273973(-) A-I      intronic chr10:121274107(-) A-I      intronic chr10:121270968(-) A-I      intronic chr10:121272255(-) A-I      intronic chr10:121270948(-) A-I      intronic chr10:121280917(-) A-I      intronic chr10:121282067(-) A-I      intronic chr10:121288114(-) A-I      intronic chr10:121288263(-) A-I      intronic chr10:121282424(-) A-I      intronic chr10:121270316(-) A-I      intronic chr10:121270988(-) A-I      intronic chr10:121272157(-) A-I      intronic chr10:121273922(-) A-I      intronic chr10:121282479(-) A-I      intronic chr10:121263840(-) A-I      intronic chr10:121283115(-) A-I      intronic chr10:121267787(-) A-I      intronic chr10:121287815(-) A-I      intronic chr10:121274123(-) A-I      intronic chr10:121283052(-) A-I      intronic chr10:121263338(-) A-I      intronic chr10:121266439(-) A-I      intronic chr10:121270874(-) A-I      intronic chr10:121281986(-) A-I      intronic chr10:121271044(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RGS10	chr10:121263338(-) A-I intron -    22327324 chr10:121274058(-) A-I intron -    22327324 chr10:121282513(-) A-I intron -    21960545 chr10:121282517(-) A-I intron -    21960545 chr10:121263338(-) A-G intron -    22484847 chr10:121270886(-) A-G intron -    22484847 chr10:121272158(-) A-G intron -    22484847 chr10:121274058(-) A-G intron -    22484847 chr10:121282424(-) A-G intron -    22484847 chr10:121282425(-) A-G intron -    22484847 chr10:121287680(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RGS10	chr10:121259353-121259354(-) m6A 3'UTR       27773535 chr10:121259382-121259383(-) m6A 3'UTR       27773535//22608085 chr10:121259404-121259405(-) m6A 3'UTR       24981863//27773535//22608085 chr10:121259515-121259516(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22608085 chr10:121259530-121259531(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22608085 chr10:121259568-121259569(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22608085 chr10:121259606-121259607(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22608085 chr10:121259662-121259663(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//22608085 chr10:121259698-121259699(-) m6A CDS//exon       24284625//24981863//28052920//26404942//27773535//22608085 chr10:121259708-121259709(-) m6A CDS//exon       24284625//24981863//28052920//26404942//27773535//22608085 chr10:121274899-121274900(-) m6A exon//intron       24284625//27773535//22608085 chr10:121274921-121274922(-) m6A exon//intron       24284625//27773535 chr10:121274932-121274933(-) m6A exon//intron       24284625//27773535 chr10:121274946-121274947(-) m6A exon//intron       27773535 chr10:121275024-121275025(-) m6A CDS//intron       27773535 chr10:121275032-121275033(-) m6A CDS//intron       27773535 chr10:121286935-121286936(-) m6A CDS       - chr10:121286949-121286950(-) m6A CDS//intron       - chr10:121295991-121295992(-) m6A 5'UTR//intron       - chr10:121296004-121296005(-) m6A 5'UTR//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320b	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Ovarian follicular fluid     22116803 Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Hepatoma cells     23771658 Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	RGS10	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-320b	Eloxatine 5310940 Drug interaction    RC00007663 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007662 Benzene 241 Drug interaction    RC00007661 Marine fungal metabolite 1386A - Drug interaction    RC00007664

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-320b	Topotecan       60700

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320b
Interactor2: RGS10

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.