Detail Information

Basic Information:


  VIRBase ID:  

HHID00068739

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320b:           MCL1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-320b MCL1
miRBase
Accession/Entrez ID		 MIMAT0005792 4170
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bcl2-L-3//BCL2L3//EAT//Mcl-1//MCL1-ES//mcl1/EAT//MCL1L//MCL1S//TM

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-320b
rs1156276707 chr1:116671796    G/T
rs1311857670 chr1:116671805    GCAAA/G
rs1373244526 chr1:116671806    C/T
rs1434535374 chr1:116671803    G/C
rs755613466 chr1:116671797    T/C
rs779451916 chr1:116671801    G/C
rs1303311077 chr1:224257059    A/T
rs1313950455 chr1:224257062    C/A
rs1333032274 chr1:224257051    G/T
rs1445839645 chr1:224257055    T/C
rs1465806287 chr1:224257050    TGCCC/T
rs745315768 chr1:224257052    C/T
rs769446888 chr1:224257054    C/T
rs1189118293 chr1:116671788    A/G
rs1199375375 chr1:116671794    G/A
rs1411861918 chr1:116671791    G/T
rs1469116635 chr1:116671792    C/CTGGGTTGAGAGGGCAAACAAATTAACTAAT
rs1030808536 chr1:224257064    A/T
rs774951709 chr1:224257069    T/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MCL1
chr1:150547166-150547167(-) Y 3'UTR       25219674
chr1:150547424-150547425(-) m6A 3'UTR       24981863//26404942
chr1:150547472-150547473(-) m6A 3'UTR       26404942
chr1:150547590-150547591(-) Y 3'UTR       25219674
chr1:150547632-150547633(-) m6A 3'UTR       26404942
chr1:150547747-150547748(-) m6A 3'UTR       26404942
chr1:150547800-150547801(-) m6A 3'UTR       26404942
chr1:150547820-150547821(-) m6A 3'UTR       26404942
chr1:150547851-150547852(-) m6A 3'UTR       26404942
chr1:150547875-150547876(-) m6A 3'UTR       26404942
chr1:150547902-150547903(-) m6A 3'UTR       26404942
chr1:150547985-150547986(-) m6A 3'UTR       26404942
chr1:150548068-150548069(-) m6A 3'UTR       26404942
chr1:150548154-150548155(-) m6A 3'UTR       26404942
chr1:150548172-150548173(-) m6A 3'UTR       26404942
chr1:150548209-150548210(-) m6A 3'UTR       26404942
chr1:150548222-150548223(-) m6A 3'UTR       26404942
chr1:150548589-150548590(-) m6A 3'UTR       24981863//26404942
chr1:150548638-150548639(-) m6A 3'UTR       26404942
chr1:150549312-150549313(-) m6A 3'UTR       26404942
chr1:150549407-150549408(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:150549533-150549534(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549538-150549539(-) Y 3'UTR//exon       25219674
chr1:150549553-150549554(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549588-150549589(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549619-150549620(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549692-150549693(-) Tm 3'UTR//exon       -
chr1:150549779-150549780(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549797-150549798(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549935-150549936(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550731-150550732(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550744-150550745(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550754-150550755(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550791-150550792(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550810-150550811(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550817-150550818(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550827-150550828(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550876-150550877(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550948-150550949(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550953-150550954(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550989-150550990(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551007-150551008(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551235-150551236(-) m6A exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551372-150551373(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551422-150551423(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551449-150551450(-) Y CDS       26075521
chr1:150551791-150551792(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960
chr1:150551973-150551974(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150552109-150552110(-) m6A 5'UTR       -
chr1:150552124-150552125(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-320b
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Ovarian follicular fluid     22116803
Exosome Plasma     23663360
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Serum     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
MCL1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-320b
Eloxatine 5310940 Drug interaction    RC00007663
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007662
Benzene 241 Drug interaction    RC00007661
Marine fungal metabolite 1386A - Drug interaction    RC00007664
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-320b
Topotecan       60700

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-320b
Interactor2: MCL1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

Starting a new search, please wait ...