Detail Information

Basic Information:


  VIRBase ID:  

HHID00068471

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-939-5p:           LIMD2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-939-5p LIMD2
miRBase
Accession/Entrez ID		 MIMAT0004982 80774
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-939-5p
rs1327403764 chr8:144394195    C/T
rs1384036144 chr8:144394216    A/G
rs374825674 chr8:144394197    C/A
rs376683753 chr8:144394207    C/G
rs530381565 chr8:144394198    C/T
rs781946129 chr8:144394196    C/G
rs1311227571 chr8:144394211    T/A
rs1395761717 chr8:144394212    C/A
rs371302764 chr8:144394210    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LIMD2
chr17:61773277-61773278(-) m6A 3'UTR       27371828
chr17:61773338-61773339(-) m6A 3'UTR       25456834//27371828
chr17:61773351-61773352(-) m6A 3'UTR       25456834//27371828
chr17:61773421-61773422(-) m6A 3'UTR       24284625//25456834//27371828
chr17:61773466-61773467(-) m6A 3'UTR       24284625//25456834//27371828
chr17:61773514-61773515(-) m6A 3'UTR       24209618//25456834//27773535//27371828
chr17:61773520-61773521(-) m6A 3'UTR       24209618//25456834//27773535//27371828
chr17:61773674-61773675(-) m6A 3'UTR       27773535//27371828
chr17:61773714-61773715(-) m6A 3'UTR       24209618//25456834//24981863//27773535//27371828
chr17:61773800-61773801(-) m6A 3'UTR       24209618//25456834//27773535//27371828
chr17:61773832-61773833(-) m6A 3'UTR       24209618//25456834//27773535//27371828
chr17:61773842-61773843(-) m6A 3'UTR       24209618//25456834//27773535//27371828
chr17:61773889-61773890(-) m6A 3'UTR       24209618//25456834//24981863//27371828
chr17:61773958-61773959(-) m6A 3'UTR       25456834//27371828
chr17:61773988-61773989(-) m6A 3'UTR       25456834//27371828
chr17:61774016-61774017(-) m6A 3'UTR       25456834//27371828
chr17:61774045-61774046(-) m6A 3'UTR       25456834//27371828
chr17:61774312-61774313(-) m6A 3'UTR       25456834//27371828
chr17:61774379-61774380(-) m6A 3'UTR       25456834//24981863//27371828
chr17:61774385-61774386(-) m6A 3'UTR       25456834//24981863//27371828
chr17:61774402-61774403(-) m6A 3'UTR       25456834//24981863//27371828
chr17:61774458-61774459(-) m6A 3'UTR       25456834//24981863//27371828//27773536
chr17:61774479-61774480(-) m6A 3'UTR       25456834//24981863//27371828//27773536
chr17:61774497-61774498(-) m6A 3'UTR       25456834//24981863//27371828
chr17:61774527-61774528(-) m6A 3'UTR       25456834//24981863//27371828
chr17:61774535-61774536(-) m6A 3'UTR       25456834//24981863//27371828
chr17:61774556-61774557(-) m6A 3'UTR       25456834//24981863//27371828
chr17:61775193-61775194(-) m6A 3'UTR//exon       28052920//27773535
chr17:61775328-61775329(-) m6A 3'UTR//exon       25456834//24981863//28052920//26404942//27773536
chr17:61775338-61775339(-) m6A 3'UTR//exon       25456834//24981863//28052920//26404942//27773536
chr17:61775474-61775475(-) m6A 3'UTR//exon       28052920
chr17:61775536-61775537(-) m6A 3'UTR//exon       28052920//27773536
chr17:61775644-61775645(-) m6A 3'UTR//exon       25456834//27773535//27773536
chr17:61775714-61775715(-) m6A 3'UTR//exon       25456834//27773536
chr17:61775758-61775759(-) m6A 3'UTR//exon//intron       25456834//24981863//27773536
chr17:61775782-61775783(-) m6A 3'UTR//exon//intron       25456834//24981863//27773536
chr17:61775933-61775934(-) m6A CDS//exon       25456834
chr17:61776246-61776247(-) m6A 5'UTR//CDS//exon//intron       27773536
chr17:61776267-61776268(-) m6A 5'UTR//CDS//exon//intron       27773536
chr17:61776582-61776583(-) m6A exon//intron       27773536
chr17:61776706-61776707(-) m6A 5'UTR//exon       25456834//27773536
chr17:61776838-61776839(-) m6A exon//intron       27773536
chr17:61776895-61776896(-) m6A exon//intron       27773536
chr17:61777351-61777352(-) m6A exon//intron       27371828//27773536
chr17:61777423-61777424(-) m6A 5'UTR//exon//intron       27371828//27773536
chr17:61777483-61777484(-) m6A 5'UTR//exon//intron       25456834//27371828
chr17:61777834-61777835(-) m6A 5'UTR//intron       25456834//27371828
chr17:61777927-61777928(-) m6A 5'UTR//intron       25456834//27371828
chr17:61778032-61778033(-) m6A 5'UTR//intron       27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-939-5p
Exosome B cell line (Raji)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
LIMD2
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-939-5p
2-(2,4-Difluorophenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione 9905583 Drug sensitive
[(1R,2Z,4R,8R,9R,11R,12S)-1,12-Dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (Z)-2-methylbut-2-enoate 90475906 Drug sensitive
Artelasticin 5471311 Drug sensitive
Herveline O 5459269 Drug sensitive
3-Iodoacetamido-benzoic acid ethyl ester 398530 Drug sensitive
(-)7,8-Dihydrocalanolide A 383107 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Aplidazole C . TFA 362402 Drug sensitive
6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive
1H-Benzo[a]carbazole-1,4(11H)-dione, 11-methyl- 261066 Drug sensitive
Prumycin HCl 24197905 Drug resistant
9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive
P-Dioxane,5-bis[(benzoyloxymercuri)methyl]- 16683647 Drug sensitive
(3As,3bR)-3b-hydroxy-3a,5,5-trimethyl-3-methylidene-4H-cyclopenta[a]pentalene-2,6-dione 15699597 Drug sensitive
(2Z,9E,13Z,15E)-4',11-Dihydroxy-2,4',9-trimethylspiro[3-aza-1(2,4)-thiazolacyclohexadecaphanene-6,3'-[1,2]dithiolane]-9,13,15-triene-4,5',12-trione 2'-oxide 154730760 Drug sensitive
5-[(E)-[Amino(methyl)amino]azo]-1H-imidazole-4-carboxamide 135493930 Drug sensitive
DTIC-Dome 135398738 Drug sensitive
Melampodinin 11953936 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
(1s,2e,4r,7e,11e)-4-hydroxy-2,7,11-cembratrien-6-one - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis - Drug sensitive
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive
[bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug sensitive
2'-deoxy-2'-methoxycarbonylmethylidine-uridine - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-939-5p
Gemcitabine 60750 Drug interaction    RC00007524
Eloxatine 5310940 Drug interaction    RC00007528
Imatinib 5291 Drug interaction    RC00007523
Bortezomib 387447 Drug interaction    RC00007526
5-Fluorouracil 3385 Drug interaction    RC00007522
Tamoxifen 2733526 Drug interaction    RC00007527
Ginsenoside Rh2 119307 Drug interaction    RC00007525

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-939-5p
Interactor2: LIMD2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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