Detail Information

Basic Information:


  VIRBase ID:  

HHID00068468

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-939-5p:           NAT10:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-939-5p NAT10
miRBase
Accession/Entrez ID		 MIMAT0004982 55226
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ALP//Kre33//NET43

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-939-5p
rs1327403764 chr8:144394195    C/T
rs1384036144 chr8:144394216    A/G
rs374825674 chr8:144394197    C/A
rs376683753 chr8:144394207    C/G
rs530381565 chr8:144394198    C/T
rs781946129 chr8:144394196    C/G
rs1311227571 chr8:144394211    T/A
rs1395761717 chr8:144394212    C/A
rs371302764 chr8:144394210    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NAT10
chr11:34149821(+) A-I      intronic
chr11:34149842(+) A-I      intronic
chr11:34149826(+) A-I      intronic
chr11:34128610(+) A-I      intronic
chr11:34149820(+) A-I      intronic
chr11:34155590(+) A-I      intronic
chr11:34128661(+) A-I      intronic
chr11:34157729(+) A-I      intronic
chr11:34149846(+) A-I      intronic
chr11:34129213(+) A-I      intronic
chr11:34147295(+) A-I      intronic
chr11:34151418(+) A-I      intronic
chr11:34149780(+) A-I      intronic
chr11:34155600(+) A-I      intronic
chr11:34151219(+) A-I      intronic
chr11:34128784(+) A-I      intronic
chr11:34147300(+) A-I      intronic
chr11:34128698(+) A-I      intronic
chr11:34129405(+) A-I      intronic
chr11:34155596(+) A-I      intronic
chr11:34129301(+) A-I      intronic
chr11:34143169(+) A-I      intronic
chr11:34128798(+) A-I      intronic
chr11:34129250(+) A-I      intronic
chr11:34128829(+) A-I      intronic
chr11:34129350(+) A-I      intronic
chr11:34157359(+) A-I      intronic
chr11:34129219(+) A-I      intronic
chr11:34129342(+) A-I      intronic
chr11:34143616(+) A-I      intronic
chr11:34147470(+) A-I      intronic
chr11:34129264(+) A-I      intronic
chr11:34143602(+) A-I      intronic
chr11:34147255(+) A-I      intronic
chr11:34143153(+) A-I      intronic
chr11:34128680(+) A-I      intronic
chr11:34129347(+) A-I      intronic
chr11:34129403(+) A-I      intronic
chr11:34157363(+) A-I      intronic
chr11:34129311(+) A-I      intronic
chr11:34129328(+) A-I      intronic
chr11:34157771(+) A-I      intronic
chr11:34153505(+) A-I      intronic
chr11:34157812(+) A-I      intronic
chr11:34138167(+) A-I      intronic
chr11:34149722(+) A-I      intronic
chr11:34128817(+) A-I      intronic
chr11:34157648(+) A-I      intronic
chr11:34128681(+) A-I      intronic
chr11:34157358(+) A-I      intronic
chr11:34140323(+) A-I      intronic
chr11:34149648(+) A-I      intronic
chr11:34157685(+) A-I      intronic
chr11:34128671(+) A-I      intronic
chr11:34129354(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NAT10
chr11:34128680(+) A-I intron -    22327324
chr11:34128680(+) A-G intron -    22484847
chr11:34128681(+) A-G intron -    22484847
chr11:34129219(+) A-G intron -    22484847
chr11:34129342(+) A-G intron -    22484847
chr11:34129347(+) A-G intron -    22484847
chr11:34129354(+) A-G intron -    22484847
chr11:34129403(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NAT10
chr11:34127226-34127227(+) m6A 5'UTR//exon       24284625//24981863//22575960
chr11:34135341-34135342(+) Y CDS       26075521
chr11:34139120-34139121(+) Cm intron       -
chr11:34145928-34145929(+) m6A CDS//intron       -
chr11:34145938-34145939(+) m6A CDS//intron       -
chr11:34149050-34149051(+) m6A CDS//intron       -
chr11:34152456-34152457(+) m6A CDS//intron       -
chr11:34163346-34163347(+) m6A CDS//intron       24209618//24981863//27773535
chr11:34163850-34163851(+) m6A CDS//exon//intron       24209618//24981863//27773535
chr11:34163885-34163886(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535
chr11:34165035-34165036(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr11:34167657-34167658(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr11:34167663-34167664(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr11:34167669-34167670(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr11:34167689-34167690(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr11:34167697-34167698(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr11:34167704-34167705(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr11:34167720-34167721(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr11:34167748-34167749(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr11:34167795-34167796(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr11:34167810-34167811(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr11:34167936-34167937(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr11:34168168-34168169(+) m6A 3'UTR       24284625//24981863
chr11:34168190-34168191(+) m6A 3'UTR       24284625
chr11:34168285-34168286(+) m6A 3'UTR//exon       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-939-5p
Exosome B cell line (Raji)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
NAT10
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-939-5p
2-(2,4-Difluorophenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione 9905583 Drug sensitive
[(1R,2Z,4R,8R,9R,11R,12S)-1,12-Dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (Z)-2-methylbut-2-enoate 90475906 Drug sensitive
Artelasticin 5471311 Drug sensitive
Herveline O 5459269 Drug sensitive
3-Iodoacetamido-benzoic acid ethyl ester 398530 Drug sensitive
(-)7,8-Dihydrocalanolide A 383107 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Aplidazole C . TFA 362402 Drug sensitive
6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive
1H-Benzo[a]carbazole-1,4(11H)-dione, 11-methyl- 261066 Drug sensitive
Prumycin HCl 24197905 Drug resistant
9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive
P-Dioxane,5-bis[(benzoyloxymercuri)methyl]- 16683647 Drug sensitive
(3As,3bR)-3b-hydroxy-3a,5,5-trimethyl-3-methylidene-4H-cyclopenta[a]pentalene-2,6-dione 15699597 Drug sensitive
(2Z,9E,13Z,15E)-4',11-Dihydroxy-2,4',9-trimethylspiro[3-aza-1(2,4)-thiazolacyclohexadecaphanene-6,3'-[1,2]dithiolane]-9,13,15-triene-4,5',12-trione 2'-oxide 154730760 Drug sensitive
5-[(E)-[Amino(methyl)amino]azo]-1H-imidazole-4-carboxamide 135493930 Drug sensitive
DTIC-Dome 135398738 Drug sensitive
Melampodinin 11953936 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
(1s,2e,4r,7e,11e)-4-hydroxy-2,7,11-cembratrien-6-one - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis - Drug sensitive
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive
[bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug sensitive
2'-deoxy-2'-methoxycarbonylmethylidine-uridine - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-939-5p
Gemcitabine 60750 Drug interaction    RC00007524
Eloxatine 5310940 Drug interaction    RC00007528
Imatinib 5291 Drug interaction    RC00007523
Bortezomib 387447 Drug interaction    RC00007526
5-Fluorouracil 3385 Drug interaction    RC00007522
Tamoxifen 2733526 Drug interaction    RC00007527
Ginsenoside Rh2 119307 Drug interaction    RC00007525

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-939-5p
Interactor2: NAT10

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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