Detail Information

Basic Information:


  VIRBase ID:  

HHID00068459

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-939-5p:           ZFP36:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-939-5p ZFP36
miRBase
Accession/Entrez ID		 MIMAT0004982 7538
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - G0S24//GOS24//NUP475//RNF162A//TIS11//TTP//zfp-36

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-939-5p
rs1327403764 chr8:144394195    C/T
rs1384036144 chr8:144394216    A/G
rs374825674 chr8:144394197    C/A
rs376683753 chr8:144394207    C/G
rs530381565 chr8:144394198    C/T
rs781946129 chr8:144394196    C/G
rs1311227571 chr8:144394211    T/A
rs1395761717 chr8:144394212    C/A
rs371302764 chr8:144394210    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZFP36
chr19:39897641-39897642(+) m6A CDS//intron       24981863
chr19:39897729-39897730(+) m6A CDS//intron       24981863
chr19:39898093-39898094(+) m6A CDS//intron       25456834//24981863
chr19:39898100-39898101(+) m6A CDS//intron       25456834//24981863
chr19:39898115-39898116(+) m6A CDS//intron       25456834
chr19:39898433-39898434(+) m6A 3'UTR//CDS       25456834
chr19:39898465-39898466(+) m6A 3'UTR//CDS       24284625
chr19:39898673-39898674(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942
chr19:39898688-39898689(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942
chr19:39898792-39898793(+) m6A 3'UTR//CDS       24284625//25456834//24981863//26404942
chr19:39898869-39898870(+) m6A CDS       24284625//24209618//25456834//24981863//26404942
chr19:39898943-39898944(+) m6A CDS       24284625//24209618//25456834//24981863
chr19:39899028-39899029(+) m6A CDS       24284625//25456834//24981863
chr19:39899088-39899089(+) m6A CDS       24284625//25456834//24981863
chr19:39899168-39899169(+) m6A CDS       24284625//24981863
chr19:39899413-39899414(+) m6A 3'UTR       25456834//24981863//26404942
chr19:39899430-39899431(+) m6A 3'UTR       25456834//24981863//26404942
chr19:39899439-39899440(+) m6A 3'UTR       25456834//24981863//26404942
chr19:39899703-39899704(+) m6A 3'UTR       27773535
chr19:39899735-39899736(+) m6A 3'UTR       27773535
chr19:39899804-39899805(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-939-5p
Exosome B cell line (Raji)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
ZFP36
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-939-5p
2-(2,4-Difluorophenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione 9905583 Drug sensitive
[(1R,2Z,4R,8R,9R,11R,12S)-1,12-Dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (Z)-2-methylbut-2-enoate 90475906 Drug sensitive
Artelasticin 5471311 Drug sensitive
Herveline O 5459269 Drug sensitive
3-Iodoacetamido-benzoic acid ethyl ester 398530 Drug sensitive
(-)7,8-Dihydrocalanolide A 383107 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Aplidazole C . TFA 362402 Drug sensitive
6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive
1H-Benzo[a]carbazole-1,4(11H)-dione, 11-methyl- 261066 Drug sensitive
Prumycin HCl 24197905 Drug resistant
9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive
P-Dioxane,5-bis[(benzoyloxymercuri)methyl]- 16683647 Drug sensitive
(3As,3bR)-3b-hydroxy-3a,5,5-trimethyl-3-methylidene-4H-cyclopenta[a]pentalene-2,6-dione 15699597 Drug sensitive
(2Z,9E,13Z,15E)-4',11-Dihydroxy-2,4',9-trimethylspiro[3-aza-1(2,4)-thiazolacyclohexadecaphanene-6,3'-[1,2]dithiolane]-9,13,15-triene-4,5',12-trione 2'-oxide 154730760 Drug sensitive
5-[(E)-[Amino(methyl)amino]azo]-1H-imidazole-4-carboxamide 135493930 Drug sensitive
DTIC-Dome 135398738 Drug sensitive
Melampodinin 11953936 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
(1s,2e,4r,7e,11e)-4-hydroxy-2,7,11-cembratrien-6-one - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis - Drug sensitive
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive
[bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug sensitive
2'-deoxy-2'-methoxycarbonylmethylidine-uridine - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-939-5p
Gemcitabine 60750 Drug interaction    RC00007524
Eloxatine 5310940 Drug interaction    RC00007528
Imatinib 5291 Drug interaction    RC00007523
Bortezomib 387447 Drug interaction    RC00007526
5-Fluorouracil 3385 Drug interaction    RC00007522
Tamoxifen 2733526 Drug interaction    RC00007527
Ginsenoside Rh2 119307 Drug interaction    RC00007525

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-939-5p
Interactor2: ZFP36

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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