Detail Information

Basic Information:


  VIRBase ID:  

HHID00068324

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-301b-3p:           NPTN:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-301b-3p NPTN
miRBase
Accession/Entrez ID		 MIMAT0004958 27020
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - GP55//GP65//np55//np65//SDFR1//SDR1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-301b-3p
rs1220123890 chr22:21653046    G/A
rs1226670983 chr22:21653034    G/T
rs1231224722 chr22:21653025    C/T
rs1291500859 chr22:21653038    T/C
rs1451855707 chr22:21653043    A/G
rs1299084984 chr22:21653027    G/A
rs751706590 chr22:21653030    C/CAATG

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NPTN
chr15:73866949(-) A-I      intronic
chr15:73866902(-) A-I      intronic
chr15:73866918(-) A-I      intronic
chr15:73866950(-) A-I      intronic
chr15:73874422(-) A-I      intronic
chr15:73906138(-) A-I      intronic
chr15:73906119(-) A-I      intronic
chr15:73906094(-) A-I      intronic
chr15:73902572(-) A-I      intronic
chr15:73902566(-) A-I      intronic
chr15:73902524(-) A-I      intronic
chr15:73902506(-) A-I      intronic
chr15:73901950(-) A-I      intronic
chr15:73901889(-) A-I      intronic
chr15:73901872(-) A-I      intronic
chr15:73901860(-) A-I      intronic
chr15:73901850(-) A-I      intronic
chr15:73901807(-) A-I      intronic
chr15:73867027(-) A-I      intronic
chr15:73866886(-) A-I      intronic
chr15:73901728(-) A-I      intronic
chr15:73919525(-) A-I      intronic
chr15:73916022(-) A-I      intronic
chr15:73915952(-) A-I      intronic
chr15:73906623(-) A-I      intronic
chr15:73906195(-) A-I      intronic
chr15:73919428(-) A-I      intronic
chr15:73906617(-) A-I      intronic
chr15:73901824(-) A-I      intronic
chr15:73906566(-) A-I      intronic
chr15:73906253(-) A-I      intronic
chr15:73905077(-) A-I      intronic
chr15:73902525(-) A-I      intronic
chr15:73901800(-) A-I      intronic
chr15:73902551(-) A-I      intronic
chr15:73853897(-) A-I      intronic
chr15:73902611(-) A-I      intronic
chr15:73906545(-) A-I      intronic
chr15:73882284(-) A-I      intronic
chr15:73867543(-) A-I      intronic
chr15:73917811(-) A-I      intronic
chr15:73915946(-) A-I      intronic
chr15:73906592(-) A-I      intronic
chr15:73915880(-) A-I      intronic
chr15:73919407(-) A-I      intronic
chr15:73906164(-) A-I      intronic
chr15:73904729(-) A-I      intronic
chr15:73906585(-) A-I      intronic
chr15:73866882(-) A-I      intronic
chr15:73902592(-) A-I      intronic
chr15:73866908(-) A-I      intronic
chr15:73906159(-) A-I      intronic
chr15:73906577(-) A-I      intronic
chr15:73919464(-) A-I      intronic
chr15:73906660(-) A-I      intronic
chr15:73906628(-) A-I      intronic
chr15:73919494(-) A-I      intronic
chr15:73906615(-) A-I      intronic
chr15:73906539(-) A-I      intronic
chr15:73906579(-) A-I      intronic
chr15:73919413(-) A-I      intronic
chr15:73906254(-) A-I      intronic
chr15:73906549(-) A-I      intronic
chr15:73906299(-) A-I      intronic
chr15:73866892(-) A-I      intronic
chr15:73881555(-) A-I      intronic
chr15:73917801(-) A-I      intronic
chr15:73906306(-) A-I      intronic
chr15:73882342(-) A-I      intronic
chr15:73919393(-) A-I      intronic
chr15:73901750(-) A-I      intronic
chr15:73906165(-) A-I      intronic
chr15:73906220(-) A-I      intronic
chr15:73901936(-) A-I      intronic
chr15:73919319(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NPTN
chr15:73852775-73852776(-) m6A 3'UTR       26404942
chr15:73852825-73852826(-) m6A 3'UTR       26404942
chr15:73853333-73853334(-) m6A 3'UTR//exon       26404942
chr15:73853371-73853372(-) m6A 3'UTR//exon       26404942
chr15:73854260-73854261(-) m6A 3'UTR//CDS//exon       24981863//26404942//27773535
chr15:73854275-73854276(-) m6A 3'UTR//CDS//exon       24981863//26404942//27773535
chr15:73854306-73854307(-) m6A CDS//exon       24981863//26404942//27773535
chr15:73855581-73855582(-) m6A CDS//exon       24981863//26404942//27773535
chr15:73855590-73855591(-) m6A CDS//exon//intron       24981863//26404942//27773535
chr15:73855608-73855609(-) m6A exon//intron       24981863//27773535
chr15:73855613-73855614(-) m6A exon//intron       24981863//27773535
chr15:73862675-73862676(-) m6A CDS//exon       26404942//27773535//27371828
chr15:73862688-73862689(-) Cm CDS//exon       -
chr15:73862693-73862694(-) m6A CDS//exon       26404942//27773535//27371828
chr15:73862702-73862703(-) m6A CDS//exon       26404942//27773535//27371828
chr15:73866039-73866040(-) m6A CDS//exon       26404942//27773535//22575960
chr15:73866099-73866100(-) m6A CDS//exon       27773535
chr15:73884347-73884348(-) m6A CDS//exon//intron       26404942//27773535
chr15:73884364-73884365(-) m6A CDS//exon//intron       26404942//27773535
chr15:73884438-73884439(-) m6A CDS//exon//intron       27773535
chr15:73889412-73889413(-) m6A CDS//intron       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-301b-3p
Cytoplasm Neural progenitor cells     21363885
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Plasma     23663360
Exosome Endothelial cells     -
Microvesicle Colon cancer cell line (LIM1863)     -
NPTN
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-301b-3p
Iodine Green 9956454 Drug sensitive
Sensorad 99342 Drug sensitive
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug resistant
5-Iodo-8-quinolinol 96111 Drug sensitive
Tetraethyleniminobenzo-quinone 95735 Drug resistant
2,5-Dimethyl-1,4-benzoquinone 8718 Drug sensitive
Acridine Yellow G 8672 Drug sensitive
Pingyangmycin 84046 Drug resistant
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
L-2-Aminobutyric acid 80283 Drug sensitive
4,7-Diphenyl-1,10-phenanthroline 72812 Drug sensitive
Dermocybin 72742 Drug sensitive
Morpholine-N-dithiocarbamate 72675 Drug sensitive
Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive
7-Hydroxystaurosporine 72271 Drug sensitive
Edatrexate 6917908 Drug sensitive
Sulbentine 67686 Drug sensitive
Kikubasaponin 6712587 Drug resistant
Neocuproine 65237 Drug sensitive
Ursolic acid 64945 Drug sensitive
Mevastatin 64715 Drug resistant
trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive
Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Iejimalide A. 5473233 Drug sensitive
Artelasticin 5471311 Drug sensitive
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive
Antineoplastic-328785 54607693 Drug sensitive
Bleomycin 5460769 Drug resistant
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Simvastatin 54454 Drug resistant
Melampodin B acetate 5359212 Drug sensitive
Hemiasterlin 5352092 Drug sensitive
4-Cycloheptyl-N-(1-pyridin-2-ylethylideneamino)piperazine-1-carbothioamide 5351332 Drug sensitive
Hydroxy AT 125 5351254 Drug sensitive
Reumycin 5351216 Drug resistant
Lovastatin 53232 Drug resistant
Herbimycin 5311102 Drug sensitive
Vorinostat 5311 Drug sensitive
Plumericin 5281545 Drug sensitive
Erioflorin acetate 5281443 Drug sensitive
Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug sensitive
6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive
BAS100 Monohydrate 45028404 Drug sensitive
Suavedol 442245 Drug sensitive
Fastigilin B 442241 Drug sensitive
Elephantopin 442206 Drug sensitive
Bleomycin-BAPP 431594 Drug resistant
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide 42640 Drug sensitive
5-(Chloromethyl)quinolin-8-ol 416881 Drug sensitive
Ethanone, 1-[3-(bromomethyl)-1,4-dioxido-2-quinoxalinyl]- 404859 Drug sensitive
Rogiolol 402519 Drug sensitive
(2S)-2,6-Diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxochromen-2-yl)-2-fluorophenyl]hexanamide;methanesulfonic acid 399587 Drug sensitive
Massoia lactone 39914 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
Lapachol 3884 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
4-Phenacyloxychromen-2-one 386272 Drug resistant
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
1-Azido-2-phenyl-3-phenalenone 381891 Drug sensitive
(1R)-3,3-Dibromocamphor 376765 Drug sensitive
3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive
N-Hydroxy-N-methylpropanethioamide 371713 Drug sensitive
Tetrakis(8-chinolineolato)titanium(IV)-tetrahydrochloride 368279 Drug sensitive
3-Nitro-5-formylisoxazole 362479 Drug sensitive
Discorhabdin C . TFA 362393 Drug sensitive
Thiosangivamycin 3580213 Drug sensitive
Predorine 333830 Drug sensitive
Rustaiyan A 324967 Drug sensitive
Ellipticine 3213 Drug sensitive
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive
N,N-Dibenzyldaunorubicin 3081598 Drug sensitive
Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug sensitive
1,1-Dimethyl-5-(2-naphthalenyl)dithiobiuret 3004012 Drug sensitive
Gardenin A 261859 Drug resistant
Hydrazine sulfate 24842 Drug sensitive
Antimycin A3 245869 Drug sensitive
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug sensitive
1-[1-(Diethylamino)propan-2-ylamino]-4-nitrothioxanthen-9-one;chloride 24186469 Drug resistant
Scillirosidin, glycoside 222160 Drug sensitive
4-[[(8-Hydroxyquinolin-7-yl)-phenylmethyl]amino]benzoic acid 219564 Drug sensitive
(1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 20835084 Drug sensitive
8-Hydroxyquinoline 1923 Drug sensitive
Sudan II 18386 Drug sensitive
4-Chloro-5-(pyridin-2-ylthio)-3H-1,2-dithiole-3-thione 16766538 Drug sensitive
Dihydroartemisinin (mixture of alpha and beta isomers) 16399850 Drug sensitive
Acrovestone 159969 Drug sensitive
Antineoplastic-633273 15954131 Drug sensitive
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug sensitive
Inosine dialdehyde 135400916 Drug sensitive
43-Dioxypectenotoxin 131751434 Drug resistant
Unii-C616DV5Y11 117587576 Drug sensitive
Cyanoaminopyranopyridine derivatives 11494577 Drug resistant
15,16-Dihydrocuracin A 101683509 Drug sensitive
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
naphthalene-1,2-dione, 4-[(4-bromophenyl)amino]-, 1-oxime - Drug resistant
protein: pahiv4 - Drug resistant
tp4ek-k6 - Drug resistant
(z) 3,3',4,5-tetramethoxystilbene - Drug sensitive
1,4-anthracenedione, 5-hydroxy- - Drug sensitive
1,6,7,8-tetra-o-phenylcarbamoylcastnospermine - Drug sensitive
1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug sensitive
1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive
1-piperidinecarbodithioic acid, antimony complex - Drug sensitive
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive
aceanthryleno[1,2-b]quinoxaline, 12-nitro- - Drug sensitive
aquatris(1,3-diphenylpropane-1,3-dionato)neodymium(iii) - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive
ellipticine, 6-(3-aminopropyl)-, dihydrochloride - Drug sensitive
ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive
geldanamycin, n,n'-dimethyl - Drug sensitive
n,n'-di-9-acridinyl-1,6-hexanediamine - Drug sensitive
(s)(-)-methyl perillate - Drug sensitive
(Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
5-hydroxyamino camptothecin - Drug sensitive
antibiotic a54556 - Drug sensitive
antineoplastic-625543 - Drug sensitive
antineoplastic-641296 - Drug sensitive
antineoplastic-641297 - Drug sensitive
antineoplastic-654376 - Drug sensitive
antineoplastic-654379 - Drug sensitive
Carboxyphthalatoplatinum - Drug sensitive
cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
isatin dr - Drug sensitive
leucinostatine d - Drug sensitive
methyl 3-farnesylthioacetate - Drug sensitive
n-acetyl-4-s-cystaminyl phenol - Drug sensitive
obtained by culturing a strain of micromonospora - Drug sensitive
pneumocandin b(sub 0) - Drug sensitive
streptorubrin - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
thiadiazines - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-301b-3p
Gemcitabine 60750 Drug interaction    RC00007477
5-Fluorouracil 3385 Drug interaction    RC00007475
Doxorubicin 31703 Drug interaction    RC00007476
Verapamil 2520 Drug interaction    RC00007474
Docetaxel 148124 Drug interaction    RC00007478
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-301b-3p
Cisplatin 5702198       31113460
Gefitinib 123631       31113460

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-301b-3p
Interactor2: NPTN

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

Starting a new search, please wait ...