Basic Information:

  VIRBase ID:  

HHID00068145

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-3p:  MIMAT0004956          DCTN5:  NR_037573     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374b-3p	DCTN5
miRBase Accession/Entrez ID	MIMAT0004956	84516
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DCTN5	chr16:23668855(+) A-I      ncRNA chr16:23666732(+) A-I      intronic chr16:23658131(+) A-I      intronic chr16:23658099(+) A-I      intronic chr16:23654544(+) A-I      intronic chr16:23668298(+) A-I      intronic chr16:23660931(+) A-I      intronic chr16:23672900(+) A-I      intronic chr16:23672879(+) A-I      intronic chr16:23672875(+) A-I      intronic chr16:23672861(+) A-I      intronic chr16:23668965(+) A-I      intronic chr16:23668591(+) A-I      intronic chr16:23667489(+) A-I      intronic chr16:23667481(+) A-I      intronic chr16:23667457(+) A-I      intronic chr16:23667454(+) A-I      intronic chr16:23667402(+) A-I      intronic chr16:23668931(+) A-I      intronic chr16:23668786(+) A-I      intronic chr16:23668785(+) A-I      intronic chr16:23660930(+) A-I      intronic chr16:23660886(+) A-I      intronic chr16:23659909(+) A-I      intronic chr16:23658581(+) A-I      intronic chr16:23667137(+) A-I      intronic chr16:23667134(+) A-I      intronic chr16:23667128(+) A-I      intronic chr16:23667101(+) A-I      intronic chr16:23667066(+) A-I      intronic chr16:23667049(+) A-I      intronic chr16:23666929(+) A-I      intronic chr16:23664214(+) A-I      intronic chr16:23663288(+) A-I      intronic chr16:23663263(+) A-I      intronic chr16:23663109(+) A-I      intronic chr16:23661830(+) A-I      intronic chr16:23661663(+) A-I      intronic chr16:23661038(+) A-I      intronic chr16:23660980(+) A-I      intronic chr16:23660963(+) A-I      intronic chr16:23660962(+) A-I      intronic chr16:23660954(+) A-I      intronic chr16:23684185(+) A-I      3'UTR chr16:23684265(+) A-I      3'UTR chr16:23684345(+) A-I      3'UTR chr16:23668670(+) A-I      intronic chr16:23660988(+) A-I      intronic chr16:23667104(+) A-I      intronic chr16:23666724(+) A-I      intronic chr16:23660282(+) A-I      intronic chr16:23668910(+) A-I      intronic chr16:23660944(+) A-I      intronic chr16:23659854(+) A-I      intronic chr16:23669037(+) A-I      intronic chr16:23661055(+) A-I      intronic chr16:23667050(+) A-I      intronic chr16:23684699(+) A-I      3'UTR chr16:23684690(+) A-I      3'UTR chr16:23659789(+) A-I      intronic chr16:23653437(+) A-I      intronic chr16:23663072(+) A-I      intronic chr16:23663311(+) A-I      intronic chr16:23664202(+) A-I      intronic chr16:23661052(+) A-I      intronic chr16:23668053(+) A-I      intronic chr16:23667051(+) A-I      intronic chr16:23668501(+) A-I      intronic chr16:23658557(+) A-I      intronic chr16:23661074(+) A-I      intronic chr16:23661039(+) A-I      intronic chr16:23659525(+) A-I      intronic chr16:23668496(+) A-I      intronic chr16:23660361(+) A-I      intronic chr16:23661084(+) A-I      intronic chr16:23666978(+) A-I      intronic chr16:23668121(+) A-I      intronic chr16:23661702(+) A-I      intronic chr16:23668508(+) A-I      intronic chr16:23660906(+) A-I      intronic chr16:23663209(+) A-I      intronic chr16:23659770(+) A-I      intronic chr16:23660296(+) A-I      intronic chr16:23660403(+) A-I      intronic chr16:23667317(+) A-I      intronic chr16:23659757(+) A-I      intronic chr16:23660279(+) A-I      intronic chr16:23668581(+) A-I      intronic chr16:23653427(+) A-I      intronic chr16:23666774(+) A-I      intronic chr16:23660383(+) A-I      intronic chr16:23666722(+) A-I      intronic chr16:23667380(+) A-I      intronic chr16:23660364(+) A-I      intronic chr16:23664383(+) A-I      intronic chr16:23660424(+) A-I      intronic chr16:23658691(+) A-I      intronic chr16:23659781(+) A-I      intronic chr16:23668623(+) A-I      intronic chr16:23661080(+) A-I      intronic chr16:23660283(+) A-I      intronic chr16:23667363(+) A-I      intronic chr16:23667015(+) A-I      intronic chr16:23661002(+) A-I      intronic chr16:23661079(+) A-I      intronic chr16:23668818(+) A-I      ncRNA chr16:23660205(+) A-I      intronic chr16:23668812(+) A-I      ncRNA chr16:23668630(+) A-I      intronic chr16:23668862(+) A-I      ncRNA chr16:23661001(+) A-I      intronic chr16:23667487(+) A-I      intronic chr16:23668518(+) A-I      intronic chr16:23655578(+) A-I      intronic chr16:23654582(+) A-I      intronic chr16:23667005(+) A-I      intronic chr16:23668974(+) A-I      intronic chr16:23668627(+) A-I      intronic chr16:23660442(+) A-I      intronic chr16:23660215(+) A-I      intronic chr16:23668595(+) A-I      intronic chr16:23664629(+) A-I      intronic chr16:23668067(+) A-I      intronic chr16:23668576(+) A-I      intronic chr16:23667412(+) A-I      intronic chr16:23667418(+) A-I      intronic chr16:23664709(+) A-I      intronic chr16:23684689(+) A-I      3'UTR chr16:23684702(+) A-I      3'UTR chr16:23684186(+) A-I      3'UTR chr16:23684193(+) A-I      3'UTR chr16:23684625(+) A-I      3'UTR chr16:23684194(+) A-I      3'UTR chr16:23684328(+) A-I      3'UTR chr16:23684636(+) A-I      3'UTR chr16:23684650(+) A-I      3'UTR chr16:23684645(+) A-I      3'UTR chr16:23684246(+) A-I      3'UTR chr16:23684647(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DCTN5	chr16:23684636(+) A-I intron -    21960545 chr16:23660364(+) A-G intron -    22484847 chr16:23661074(+) A-G intron -    22484847 chr16:23684186(+) A-G intron -    22484847 chr16:23684193(+) A-G intron -    22484847 chr16:23684194(+) A-G intron -    22484847 chr16:23684625(+) A-G intron -    22484847 chr16:23684636(+) A-G intron -    22484847 chr16:23684702(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DCTN5	chr16:23652810-23652811(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22608085 chr16:23653939-23653940(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr16:23653946-23653947(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr16:23654215-23654216(+) m6A 5'UTR//intron       24981863 chr16:23654230-23654231(+) m6A 5'UTR//intron       24981863 chr16:23654285-23654286(+) m6A 5'UTR//CDS       24981863 chr16:23654324-23654325(+) m6A 5'UTR//CDS       24981863 chr16:23678368-23678369(+) m6A 3'UTR//CDS//exon       24284625//22608085 chr16:23678508-23678509(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:23678516-23678517(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:23678646-23678647(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr16:23678700-23678701(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr16:23678728-23678729(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr16:23678798-23678799(+) m6A 3'UTR//exon       24284625//24981863//22575960//22608085 chr16:23679007-23679008(+) m6A 3'UTR//exon       24284625//22608085 chr16:23679084-23679085(+) m6A 3'UTR//exon       24284625//22608085 chr16:23679133-23679134(+) m6A 3'UTR//exon       24284625 chr16:23679247-23679248(+) m6A 3'UTR//exon       24284625 chr16:23679262-23679263(+) m6A 3'UTR//exon       24284625 chr16:23679283-23679284(+) m6A 3'UTR//exon       24284625 chr16:23679313-23679314(+) m6A 3'UTR//exon       24284625 chr16:23679929-23679930(+) m6A 3'UTR//exon       24284625 chr16:23679988-23679989(+) m6A 3'UTR//exon       24284625 chr16:23679999-23680000(+) m6A 3'UTR//exon       24284625 chr16:23680277-23680278(+) m6A 3'UTR//exon       24981863//22608085 chr16:23680293-23680294(+) m6A 3'UTR//exon       24981863//22608085 chr16:23680299-23680300(+) m6A 3'UTR//exon       24981863//22608085 chr16:23680315-23680316(+) m6A 3'UTR//exon       24981863//22608085 chr16:23680399-23680400(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr16:23680431-23680432(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr16:23680439-23680440(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr16:23680515-23680516(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr16:23680532-23680533(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr16:23680544-23680545(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr16:23680635-23680636(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:23680642-23680643(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:23680764-23680765(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr16:23680855-23680856(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:23680880-23680881(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:23680954-23680955(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:23681333-23681334(+) m6A 3'UTR       - chr16:23681467-23681468(+) m6A 3'UTR       - chr16:23682726-23682727(+) m6A 3'UTR       24981863 chr16:23682758-23682759(+) m6A 3'UTR       24981863 chr16:23685328-23685329(+) m6A 3'UTR       - chr16:23685442-23685443(+) m6A 3'UTR       - chr16:23685494-23685495(+) m6A 3'UTR       - chr16:23685525-23685526(+) m6A 3'UTR       - chr16:23685556-23685557(+) m6A 3'UTR       - chr16:23685577-23685578(+) m6A 3'UTR       - chr16:23685596-23685597(+) m6A 3'UTR       - chr16:23685628-23685629(+) m6A 3'UTR       - chr16:23685743-23685744(+) m6A 3'UTR       - chr16:23685772-23685773(+) m6A 3'UTR       - chr16:23685777-23685778(+) m6A 3'UTR       - chr16:23685783-23685784(+) m6A 3'UTR       - chr16:23685861-23685862(+) m6A 3'UTR       - chr16:23687181-23687182(+) m6A 3'UTR       - chr16:23687190-23687191(+) m6A 3'UTR       - chr16:23687200-23687201(+) m6A 3'UTR       - chr16:23687236-23687237(+) m6A 3'UTR       - chr16:23687245-23687246(+) m6A 3'UTR       - chr16:23687259-23687260(+) m6A 3'UTR       - chr16:23687266-23687267(+) m6A 3'UTR       - chr16:23687390-23687391(+) m6A 3'UTR       - chr16:23688426-23688427(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374b-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	DCTN5	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374b-3p
Interactor2: DCTN5

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.