Basic Information:

  VIRBase ID:  

HHID00068141

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-3p:  MIMAT0004956          SECISBP2:  NM_024077     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374b-3p	SECISBP2
miRBase Accession/Entrez ID	MIMAT0004956	79048
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SBP2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SECISBP2	chr9:91950035(+) A-I      intronic chr9:91950400(+) A-I      intronic chr9:91942830(+) A-I      intronic chr9:91950463(+) A-I      intronic chr9:91942820(+) A-I      intronic chr9:91942806(+) A-I      intronic chr9:91942800(+) A-I      intronic chr9:91941889(+) A-I      intronic chr9:91950462(+) A-I      intronic chr9:91950428(+) A-I      intronic chr9:91950445(+) A-I      intronic chr9:91950081(+) A-I      intronic chr9:91950309(+) A-I      intronic chr9:91950312(+) A-I      intronic chr9:91949944(+) A-I      intronic chr9:91950375(+) A-I      intronic chr9:91949875(+) A-I      intronic chr9:91950348(+) A-I      intronic chr9:91941997(+) A-I      intronic chr9:91949973(+) A-I      intronic chr9:91949942(+) A-I      intronic chr9:91950088(+) A-I      intronic chr9:91942921(+) A-I      intronic chr9:91950020(+) A-I      intronic chr9:91950448(+) A-I      intronic chr9:91941920(+) A-I      intronic chr9:91950341(+) A-I      intronic chr9:91949896(+) A-I      intronic chr9:91950010(+) A-I      intronic chr9:91949952(+) A-I      intronic chr9:91950352(+) A-I      intronic chr9:91942826(+) A-I      intronic chr9:91944564(+) A-I      ncRNA chr9:91949946(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SECISBP2	chr9:91949942(+) A-G intron -    22484847 chr9:91949946(+) A-G intron -    22484847 chr9:91950052(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SECISBP2	chr9:91938404-91938405(+) m6A exon//intron       22575960 chr9:91938450-91938451(+) m6A exon//intron       22575960 chr9:91938499-91938500(+) m6A exon//intron       22575960 chr9:91953401-91953402(+) m6A CDS//exon       27773535 chr9:91954824-91954825(+) m6A CDS//exon       24981863 chr9:91954835-91954836(+) m6A CDS//exon       24981863 chr9:91961867-91961868(+) m6A CDS       - chr9:91961886-91961887(+) m6A CDS       - chr9:91964709-91964710(+) m6A CDS//exon       24284625 chr9:91964735-91964736(+) m6A CDS//exon       24284625 chr9:91964774-91964775(+) m6A CDS//exon       24284625 chr9:91965606-91965607(+) m6A CDS//exon       24284625//24981863 chr9:91965623-91965624(+) m6A CDS//exon       24284625//24981863 chr9:91965658-91965659(+) m6A CDS//exon       24981863 chr9:91972376-91972377(+) m6A CDS//exon       - chr9:91972967-91972968(+) m6A CDS//exon       24284625 chr9:91973651-91973652(+) m6A CDS       24284625 chr9:91973792-91973793(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374b-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	SECISBP2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374b-3p
Interactor2: SECISBP2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.