Basic Information:

  VIRBase ID:  

HHID00068132

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-3p:  MIMAT0004956          RFK:  NM_018339     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374b-3p	RFK
miRBase Accession/Entrez ID	MIMAT0004956	55312
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	RIFK

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RFK	chr9:79002681(-) A-I      ncRNA chr9:79007717(-) A-I      intronic chr9:79007798(-) A-I      intronic chr9:79001882(-) A-I      3'UTR chr9:79001890(-) A-I      3'UTR chr9:79001891(-) A-I      3'UTR chr9:79007636(-) A-I      intronic chr9:79007566(-) A-I      intronic chr9:79007572(-) A-I      intronic chr9:79008350(-) A-I      intronic chr9:79008336(-) A-I      intronic chr9:79007814(-) A-I      intronic chr9:79006772(-) A-I      intronic chr9:79005498(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RFK	chr9:79001092-79001093(-) Y 3'UTR       25219674 chr9:79001295-79001296(-) m6A 3'UTR       26404942 chr9:79009094-79009095(-) m6A 5'UTR//exon       27773536 chr9:79009122-79009123(-) m6A 5'UTR//exon       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374b-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	RFK	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374b-3p
Interactor2: RFK

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.