Basic Information:

  VIRBase ID:  

HHID00068127

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-3p:  MIMAT0004956          APPL1:  NM_012096     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374b-3p	APPL1
miRBase Accession/Entrez ID	MIMAT0004956	26060
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	APPL//DIP13alpha//MODY14

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	APPL1	chr3:57265264(+) A-I      intronic chr3:57265118(+) A-I      intronic chr3:57265657(+) A-I      intronic chr3:57285474(+) A-I      intronic chr3:57263859(+) A-I      intronic chr3:57265139(+) A-I      intronic chr3:57267969(+) A-I      intronic chr3:57290178(+) A-I      intronic chr3:57265113(+) A-I      intronic chr3:57267965(+) A-I      intronic chr3:57267962(+) A-I      intronic chr3:57265112(+) A-I      intronic chr3:57265025(+) A-I      intronic chr3:57267910(+) A-I      intronic chr3:57264974(+) A-I      intronic chr3:57267952(+) A-I      intronic chr3:57268778(+) A-I      intronic chr3:57265411(+) A-I      intronic chr3:57284248(+) A-I      intronic chr3:57268905(+) A-I      intronic chr3:57268801(+) A-I      intronic chr3:57265709(+) A-I      intronic chr3:57265686(+) A-I      intronic chr3:57268777(+) A-I      intronic chr3:57268748(+) A-I      intronic chr3:57306803(+) A-I      3'UTR chr3:57306794(+) A-I      3'UTR chr3:57306809(+) A-I      3'UTR chr3:57306826(+) A-I      3'UTR chr3:57306889(+) A-I      3'UTR chr3:57306745(+) A-I      3'UTR chr3:57306898(+) A-I      3'UTR chr3:57306767(+) A-I      3'UTR chr3:57306721(+) A-I      3'UTR chr3:57306683(+) A-I      3'UTR chr3:57306793(+) A-I      3'UTR chr3:57306708(+) A-I      3'UTR chr3:57267947(+) A-I      intronic chr3:57284420(+) A-I      intronic chr3:57290162(+) A-I      intronic chr3:57265220(+) A-I      intronic chr3:57265468(+) A-I      intronic chr3:57267991(+) A-I      intronic chr3:57265486(+) A-I      intronic chr3:57268784(+) A-I      intronic chr3:57268813(+) A-I      intronic chr3:57264867(+) A-I      intronic chr3:57306647(+) A-I      3'UTR chr3:57306901(+) A-I      3'UTR chr3:57306834(+) A-I      3'UTR chr3:57267950(+) A-I      intronic chr3:57280940(+) A-I      intronic chr3:57265431(+) A-I      intronic chr3:57265436(+) A-I      intronic chr3:57267948(+) A-I      intronic chr3:57265660(+) A-I      intronic chr3:57265637(+) A-I      intronic chr3:57290116(+) A-I      intronic chr3:57267855(+) A-I      intronic chr3:57285431(+) A-I      intronic chr3:57287968(+) A-I      intronic chr3:57263883(+) A-I      intronic chr3:57285366(+) A-I      intronic chr3:57268001(+) A-I      intronic chr3:57265683(+) A-I      intronic chr3:57302076(+) A-I      intronic chr3:57268104(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	APPL1	chr3:57264867(+) A-G intron -    22484847 chr3:57265661(+) A-G intron -    22484847 chr3:57265737(+) A-G intron -    22484847 chr3:57267854(+) A-G intron -    22484847 chr3:57267947(+) A-G intron -    22484847 chr3:57267948(+) A-G intron -    22484847 chr3:57267950(+) A-G intron -    22484847 chr3:57267954(+) A-G intron -    22484847 chr3:57267991(+) A-G intron -    22484847 chr3:57268001(+) A-G intron -    22484847 chr3:57268037(+) A-G intron -    22484847 chr3:57268784(+) A-G intron -    22484847 chr3:57268813(+) A-G intron -    22484847 chr3:57284420(+) A-G intron -    22484847 chr3:57287968(+) A-G intron -    22484847 chr3:57295598(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	APPL1	chr3:57293958-57293959(+) m6A CDS//exon       - chr3:57294447-57294448(+) m6A exon//intron       - chr3:57294727-57294728(+) m6A CDS//exon       - chr3:57294785-57294786(+) m6A CDS//exon       24209618//27773535 chr3:57301786-57301787(+) m6A CDS//exon       24209618//24981863//27773535//22608085 chr3:57301795-57301796(+) m6A CDS//exon       24209618//24981863//27773535//22608085 chr3:57301816-57301817(+) m6A CDS//exon       24209618//24981863//27773535//22608085 chr3:57301920-57301921(+) m6A exon//intron       27773535//22608085 chr3:57301943-57301944(+) m6A exon//intron       22608085 chr3:57302445-57302446(+) m6A CDS       24981863//27773535//22608085 chr3:57302487-57302488(+) m6A CDS       24981863//27773535//22608085 chr3:57302496-57302497(+) m6A CDS       24981863//27773535//22608085 chr3:57302502-57302503(+) m6A CDS       24981863//27773535//22608085 chr3:57303579-57303580(+) m6A CDS       24981863//27773535//22608085 chr3:57303609-57303610(+) m6A CDS       24981863//27773535//22608085 chr3:57303614-57303615(+) m6A CDS       24981863//27773535//22608085 chr3:57303864-57303865(+) m6A 3'UTR       24209618//22608085 chr3:57303906-57303907(+) m6A 3'UTR       24284625//24981863//22608085 chr3:57303939-57303940(+) m6A 3'UTR       24284625//24981863//22608085 chr3:57303962-57303963(+) m6A 3'UTR       24284625//24981863//22608085 chr3:57304011-57304012(+) m6A 3'UTR       24284625//24981863//22608085 chr3:57305542-57305543(+) m6A 3'UTR       - chr3:57305553-57305554(+) m6A 3'UTR       - chr3:57306528-57306529(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374b-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	APPL1	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374b-3p
Interactor2: APPL1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.