Basic Information:

  VIRBase ID:  

HHID00068125

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-3p:  MIMAT0004956          IFIT5:  NM_012420     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374b-3p	IFIT5
miRBase Accession/Entrez ID	MIMAT0004956	24138
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ISG58//P58//RI58

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFIT5	chr10:91174518-91174519(+) m6A 5'UTR       24209618//24981863 chr10:91176975-91176976(+) m6A CDS       24209618//24981863//22608085 chr10:91177038-91177039(+) m6A CDS       24209618//24981863//22608085 chr10:91177105-91177106(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr10:91177138-91177139(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr10:91177180-91177181(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr10:91177207-91177208(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr10:91177215-91177216(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr10:91177251-91177252(+) m6A CDS       24209618//24981863//26404942//27773535//22575960//22608085 chr10:91177278-91177279(+) m6A CDS       24209618//24981863//26404942//27773535//22575960//22608085 chr10:91177373-91177374(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr10:91177587-91177588(+) m6A CDS       24981863//22608085 chr10:91177683-91177684(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:91177752-91177753(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr10:91177765-91177766(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr10:91177825-91177826(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:91177876-91177877(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:91177894-91177895(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:91177956-91177957(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:91177983-91177984(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:91178031-91178032(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:91178061-91178062(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:91178080-91178081(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:91178178-91178179(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:91178200-91178201(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:91178236-91178237(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374b-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	IFIT5	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374b-3p
Interactor2: IFIT5

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.