Basic Information:

  VIRBase ID:  

HHID00068119

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-3p:  MIMAT0004956          PRMT3:  NM_001145167     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374b-3p	PRMT3
miRBase Accession/Entrez ID	MIMAT0004956	10196
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HRMT1L3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PRMT3	chr11:20412388(+) A-I      intronic chr11:20412420(+) A-I      intronic chr11:20441624(+) A-I      intronic chr11:20413051(+) A-I      intronic chr11:20517018(+) A-I      intronic chr11:20516745(+) A-I      intronic chr11:20441638(+) A-I      intronic chr11:20411570(+) A-I      intronic chr11:20529241(+) A-I      intronic chr11:20441639(+) A-I      intronic chr11:20441646(+) A-I      intronic chr11:20442608(+) A-I      intronic chr11:20442723(+) A-I      intronic chr11:20442806(+) A-I      intronic chr11:20520913(+) A-I      intronic chr11:20442822(+) A-I      intronic chr11:20526444(+) A-I      intronic chr11:20442845(+) A-I      intronic chr11:20412891(+) A-I      intronic chr11:20526468(+) A-I      intronic chr11:20442861(+) A-I      intronic chr11:20442864(+) A-I      intronic chr11:20490015(+) A-I      intronic chr11:20411654(+) A-I      intronic chr11:20497300(+) A-I      intronic chr11:20497342(+) A-I      intronic chr11:20497641(+) A-I      intronic chr11:20497687(+) A-I      intronic chr11:20526540(+) A-I      intronic chr11:20526571(+) A-I      intronic chr11:20497695(+) A-I      intronic chr11:20497718(+) A-I      intronic chr11:20497731(+) A-I      intronic chr11:20517857(+) A-I      intronic chr11:20417088(+) A-I      intronic chr11:20411478(+) A-I      intronic chr11:20529580(+) A-I      intronic chr11:20515954(+) A-I      intronic chr11:20442749(+) A-I      intronic chr11:20417089(+) A-I      intronic chr11:20517841(+) A-I      intronic chr11:20520912(+) A-I      intronic chr11:20425961(+) A-I      intronic chr11:20412921(+) A-I      intronic chr11:20516019(+) A-I      intronic chr11:20516063(+) A-I      intronic chr11:20516110(+) A-I      intronic chr11:20474897(+) A-I      intronic chr11:20516502(+) A-I      intronic chr11:20516520(+) A-I      intronic chr11:20516605(+) A-I      intronic chr11:20516678(+) A-I      intronic chr11:20516878(+) A-I      intronic chr11:20516054(+) A-I      intronic chr11:20412978(+) A-I      intronic chr11:20516890(+) A-I      intronic chr11:20411590(+) A-I      intronic chr11:20517064(+) A-I      intronic chr11:20442647(+) A-I      intronic chr11:20516903(+) A-I      intronic chr11:20529116(+) A-I      intronic chr11:20526410(+) A-I      intronic chr11:20516912(+) A-I      intronic chr11:20441553(+) A-I      intronic chr11:20442774(+) A-I      intronic chr11:20516884(+) A-I      intronic chr11:20413018(+) A-I      intronic chr11:20411618(+) A-I      intronic chr11:20412972(+) A-I      intronic chr11:20526421(+) A-I      intronic chr11:20442767(+) A-I      intronic chr11:20515979(+) A-I      intronic chr11:20526555(+) A-I      intronic chr11:20474938(+) A-I      intronic chr11:20517013(+) A-I      intronic chr11:20497778(+) A-I      intronic chr11:20520958(+) A-I      intronic chr11:20520110(+) A-I      intronic chr11:20441597(+) A-I      intronic chr11:20456860(+) A-I      intronic chr11:20413050(+) A-I      intronic chr11:20497779(+) A-I      intronic chr11:20497784(+) A-I      intronic chr11:20411429(+) A-I      intronic chr11:20412892(+) A-I      intronic chr11:20515997(+) A-I      intronic chr11:20521030(+) A-I      intronic chr11:20516106(+) A-I      intronic chr11:20529150(+) A-I      intronic chr11:20413085(+) A-I      intronic chr11:20516892(+) A-I      intronic chr11:20522173(+) A-I      intronic chr11:20497820(+) A-I      intronic chr11:20412385(+) A-I      intronic chr11:20413011(+) A-I      intronic chr11:20529205(+) A-I      intronic chr11:20517062(+) A-I      intronic chr11:20441498(+) A-I      intronic chr11:20529204(+) A-I      intronic chr11:20441547(+) A-I      intronic chr11:20411497(+) A-I      intronic chr11:20412446(+) A-I      intronic chr11:20497719(+) A-I      intronic chr11:20411579(+) A-I      intronic chr11:20516021(+) A-I      intronic chr11:20412449(+) A-I      intronic chr11:20413069(+) A-I      intronic chr11:20516523(+) A-I      intronic chr11:20521031(+) A-I      intronic chr11:20521093(+) A-I      intronic chr11:20516025(+) A-I      intronic chr11:20529178(+) A-I      intronic chr11:20526406(+) A-I      intronic chr11:20526354(+) A-I      intronic chr11:20412419(+) A-I      intronic chr11:20442616(+) A-I      intronic chr11:20508074(+) A-I      intronic chr11:20517045(+) A-I      intronic chr11:20517046(+) A-I      intronic chr11:20441508(+) A-I      intronic chr11:20411491(+) A-I      intronic chr11:20515983(+) A-I      intronic chr11:20445330(+) A-I      intronic chr11:20526013(+) A-I      intronic chr11:20517007(+) A-I      intronic chr11:20521936(+) A-I      intronic chr11:20526553(+) A-I      intronic chr11:20525757(+) A-I      intronic chr11:20442697(+) A-I      intronic chr11:20411616(+) A-I      intronic chr11:20497293(+) A-I      intronic chr11:20526526(+) A-I      intronic chr11:20423193(+) A-I      intronic chr11:20516974(+) A-I      intronic chr11:20516909(+) A-I      intronic chr11:20515980(+) A-I      intronic chr11:20412418(+) A-I      intronic chr11:20442659(+) A-I      intronic chr11:20516134(+) A-I      intronic chr11:20526397(+) A-I      intronic chr11:20529050(+) A-I      intronic chr11:20516952(+) A-I      intronic chr11:20497436(+) A-I      intronic chr11:20463539(+) A-I      intronic chr11:20419465(+) A-I      intronic chr11:20529149(+) A-I      intronic chr11:20516978(+) A-I      intronic chr11:20497853(+) A-I      intronic chr11:20529488(+) A-I      intronic chr11:20529066(+) A-I      intronic chr11:20526488(+) A-I      intronic chr11:20521961(+) A-I      intronic chr11:20515904(+) A-I      intronic chr11:20526360(+) A-I      intronic chr11:20529237(+) A-I      intronic chr11:20412969(+) A-I      intronic chr11:20517843(+) A-I      intronic chr11:20412485(+) A-I      intronic chr11:20517837(+) A-I      intronic chr11:20516060(+) A-I      intronic chr11:20526514(+) A-I      intronic chr11:20516674(+) A-I      intronic chr11:20516771(+) A-I      intronic chr11:20497710(+) A-I      intronic chr11:20526379(+) A-I      intronic chr11:20517015(+) A-I      intronic chr11:20446411(+) A-I      intronic chr11:20515960(+) A-I      intronic chr11:20521092(+) A-I      intronic chr11:20426039(+) A-I      intronic chr11:20516679(+) A-I      intronic chr11:20497255(+) A-I      intronic chr11:20526081(+) A-I      intronic chr11:20429302(+) A-I      intronic chr11:20516498(+) A-I      intronic chr11:20529531(+) A-I      intronic chr11:20516105(+) A-I      intronic chr11:20516675(+) A-I      intronic chr11:20526462(+) A-I      intronic chr11:20520042(+) A-I      intronic chr11:20445522(+) A-I      intronic chr11:20526012(+) A-I      intronic chr11:20516549(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PRMT3	chr11:20526257(+) A-I intron -    22327324 chr11:20515979(+) A-G intron -    22484847 chr11:20515980(+) A-G intron -    22484847 chr11:20515983(+) A-G intron -    22484847 chr11:20516105(+) A-G intron -    22484847 chr11:20516498(+) A-G intron -    22484847 chr11:20516675(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PRMT3	chr11:20409263-20409264(+) m6A 5'UTR       24981863 chr11:20409390-20409391(+) m6A CDS//intron       24284625//24981863//22608085 chr11:20409400-20409401(+) m6A CDS//intron       24284625//24981863//22608085 chr11:20409594-20409595(+) m6A 3'UTR//CDS//intron       25456834//24981863//22608085 chr11:20409604-20409605(+) m6A 3'UTR//CDS//intron       25456834//24981863//22608085 chr11:20409612-20409613(+) m6A 3'UTR//CDS//intron       25456834//24981863//22608085 chr11:20409677-20409678(+) m6A 3'UTR//CDS//intron       25456834//22608085 chr11:20429480-20429481(+) m6A 3'UTR//CDS//exon       - chr11:20486077-20486078(+) m6A 3'UTR//CDS//exon       - chr11:20530059-20530060(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374b-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	PRMT3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374b-3p
Interactor2: PRMT3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.