Basic Information:

  VIRBase ID:  

HHID00068118

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-3p:  MIMAT0004956          FEM1B:  NM_015322     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374b-3p	FEM1B
miRBase Accession/Entrez ID	MIMAT0004956	10116
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	F1A-ALPHA//F1AA//FEM1-beta

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FEM1B	chr15:68575747(+) A-I      intronic chr15:68574214(+) A-I      intronic chr15:68575740(+) A-I      intronic chr15:68575981(+) A-I      intronic chr15:68574060(+) A-I      intronic chr15:68575820(+) A-I      intronic chr15:68575998(+) A-I      intronic chr15:68574226(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FEM1B	chr15:68570300-68570301(+) Y 5'UTR       26075521 chr15:68570379-68570380(+) m6A 5'UTR       22608085 chr15:68570503-68570504(+) m6A 5'UTR       24209618//25456834//24981863//22575960//22608085 chr15:68570925-68570926(+) m6A CDS       24284625//24209618//24981863//22608085 chr15:68570955-68570956(+) m6A CDS       24284625//24209618//24981863//22608085 chr15:68570971-68570972(+) m6A CDS       24284625//24209618//24981863//22608085 chr15:68570980-68570981(+) m6A CDS       24284625//24209618//24981863//22608085 chr15:68572338-68572339(+) m6A 5'UTR//intron       24284625//24209618//22608085 chr15:68581992-68581993(+) m6A 5'UTR//CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr15:68582010-68582011(+) m6A 5'UTR//CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr15:68582039-68582040(+) m6A 5'UTR//CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr15:68582094-68582095(+) m6A 5'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68582099-68582100(+) m6A 5'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68582190-68582191(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:68582220-68582221(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68582403-68582404(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:68582457-68582458(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:68582492-68582493(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:68582509-68582510(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:68582611-68582612(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:68582634-68582635(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:68582654-68582655(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:68582817-68582818(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68582834-68582835(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68582896-68582897(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68582912-68582913(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68582952-68582953(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68582963-68582964(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68583008-68583009(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68583064-68583065(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68583136-68583137(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68583254-68583255(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68583281-68583282(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68583293-68583294(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:68583408-68583409(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:68583418-68583419(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:68583428-68583429(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:68583466-68583467(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:68583536-68583537(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr15:68583550-68583551(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr15:68583627-68583628(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr15:68583641-68583642(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr15:68583754-68583755(+) m6A 3'UTR       24981863//22575960//22608085 chr15:68583769-68583770(+) m6A 3'UTR       24981863//22575960//22608085 chr15:68585208-68585209(+) m6A 3'UTR       26404942 chr15:68585220-68585221(+) m6A 3'UTR       26404942 chr15:68585667-68585668(+) m6A 3'UTR       27773535 chr15:68585702-68585703(+) m6A 3'UTR       27773535 chr15:68585730-68585731(+) m6A 3'UTR       27773535//22608085 chr15:68585746-68585747(+) m6A 3'UTR       27773535//22608085 chr15:68585795-68585796(+) m6A 3'UTR       24981863//26404942//27773535//22608085 chr15:68585834-68585835(+) m6A 3'UTR       24981863//26404942//27773535//22608085 chr15:68585854-68585855(+) m6A 3'UTR       24981863//26404942//27773535//22608085 chr15:68585897-68585898(+) m6A 3'UTR       24981863//26404942//27773535//22608085 chr15:68585909-68585910(+) m6A 3'UTR       24981863//27773535//22608085 chr15:68585916-68585917(+) m6A 3'UTR       24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374b-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	FEM1B	Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374b-3p
Interactor2: FEM1B

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.