Basic Information:

  VIRBase ID:  

HHID00068116

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-3p:  MIMAT0004956          POLR1C:  NM_001363658     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374b-3p	POLR1C
miRBase Accession/Entrez ID	MIMAT0004956	9533
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AC40//HLD11//RPA39//RPA40//RPA5//RPAC1//RPC40//TCS3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	POLR1C	chr6:43492035(+) A-I      intronic chr6:43491949(+) A-I      intronic chr6:43495127(+) A-I      intronic chr6:43492010(+) A-I      intronic chr6:43492011(+) A-I      intronic chr6:43495189(+) A-I      intronic chr6:43495178(+) A-I      intronic chr6:43495139(+) A-I      intronic chr6:43491817(+) A-I      intronic chr6:43491856(+) A-I      intronic chr6:43491857(+) A-I      intronic chr6:43495122(+) A-I      intronic chr6:43489363(+) A-I      intronic chr6:43495042(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	POLR1C	chr6:43484820-43484821(+) m6A 5'UTR//exon//intron       24981863 chr6:43485095-43485096(+) m6A 5'UTR//CDS//exon       24981863 chr6:43485101-43485102(+) m6A 5'UTR//CDS//exon       24981863 chr6:43487866-43487867(+) m6A CDS//exon//intron       - chr6:43487903-43487904(+) m6A CDS//exon//intron       - chr6:43487914-43487915(+) m6A CDS//exon//intron       - chr6:43489013-43489014(+) m6A CDS//exon//intron       24284625//25456834//24981863//22575960//22608085 chr6:43489033-43489034(+) m6A CDS//exon//intron       24284625//25456834//24981863//22575960//22608085 chr6:43489096-43489097(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22575960//22608085 chr6:43489104-43489105(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22575960//22608085 chr6:43489145-43489146(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22575960//22608085 chr6:43489195-43489196(+) m6A 3'UTR//exon//intron       24284625//24981863//22575960//22608085 chr6:43489232-43489233(+) m6A 3'UTR//intron       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374b-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	POLR1C	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374b-3p
Interactor2: POLR1C

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.