Basic Information:

  VIRBase ID:  

HHID00068112

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-3p:  MIMAT0004956          PTP4A1:  NR_169595     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374b-3p	PTP4A1
miRBase Accession/Entrez ID	MIMAT0004956	7803
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HH72//PRL-1//PRL1//PTP(CAAX1)//PTPCAAX1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PTP4A1	chr6:64237883-64237884(+) m6A exon       24981863 chr6:64282007-64282008(+) m6A 5'UTR//intron       24284625//27773535//22608085 chr6:64282045-64282046(+) m6A 5'UTR//intron       24284625//24981863//27773535//22608085 chr6:64282576-64282577(+) m6A 5'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr6:64282614-64282615(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr6:64283219-64283220(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr6:64286428-64286429(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:64286436-64286437(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:64286445-64286446(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:64286493-64286494(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:64286557-64286558(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:64286702-64286703(+) m6A 5'UTR       24284625//24209618//24981863//22575960//22608085 chr6:64286798-64286799(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr6:64286831-64286832(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr6:64286876-64286877(+) m6A CDS       24981863//27773535//22575960 chr6:64287373-64287374(+) Tm intron       - chr6:64288343-64288344(+) m6A CDS       24981863//27773535//22575960 chr6:64288888-64288889(+) m6A CDS       22575960 chr6:64289233-64289234(+) m6A CDS//intron       22575960 chr6:64290059-64290060(+) m6A CDS       26404942//22575960 chr6:64290110-64290111(+) m6A 3'UTR       26404942//22575960 chr6:64290488-64290489(+) m6A 3'UTR       27773535 chr6:64290495-64290496(+) m6A 3'UTR       27773535 chr6:64290502-64290503(+) m6A 3'UTR       27773535 chr6:64290535-64290536(+) m6A 3'UTR       26404942//27773535 chr6:64291113-64291114(+) m6A 3'UTR       27773535 chr6:64291307-64291308(+) m6A 3'UTR       27773535//22575960 chr6:64291326-64291327(+) m6A 3'UTR       27773535 chr6:64291401-64291402(+) m6A 3'UTR       27773535 chr6:64291496-64291497(+) m6A 3'UTR       22575960 chr6:64291524-64291525(+) m6A 3'UTR       22575960 chr6:64291582-64291583(+) m6A 3'UTR       26404942 chr6:64291883-64291884(+) m6A 3'UTR       22575960 chr6:64292133-64292134(+) m6A 3'UTR       27773535 chr6:64292167-64292168(+) m6A 3'UTR       27773535 chr6:64292190-64292191(+) m6A 3'UTR       27773535 chr6:64292241-64292242(+) m6A 3'UTR       27773535 chr6:64292959-64292960(+) m6A 3'UTR       27773535 chr6:64293122-64293123(+) m6A 3'UTR       26404942//27773535 chr6:64293153-64293154(+) m6A 3'UTR       27773535 chr6:64293267-64293268(+) m6A 3'UTR       27773535 chr6:64293365-64293366(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374b-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	PTP4A1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374b-3p
Interactor2: PTP4A1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.