Basic Information:

  VIRBase ID:  

HHID00068108

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-3p:  MIMAT0004956          STK4:  NR_147974     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374b-3p	STK4
miRBase Accession/Entrez ID	MIMAT0004956	6789
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	KRS2//MST1//YSK3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STK4	chr20:43674984(+) A-I      intronic chr20:43690082(+) A-I      intronic chr20:43706976(+) A-I      3'UTR chr20:43706972(+) A-I      3'UTR chr20:43690062(+) A-I      intronic chr20:43707861(+) A-I      3'UTR chr20:43688262(+) A-I      intronic chr20:43707794(+) A-I      3'UTR chr20:43707752(+) A-I      3'UTR chr20:43707704(+) A-I      3'UTR chr20:43707000(+) A-I      3'UTR chr20:43707867(+) A-I      3'UTR chr20:43690013(+) A-I      intronic chr20:43690014(+) A-I      intronic chr20:43634084(+) A-I      intronic chr20:43620323(+) A-I      intronic chr20:43617102(+) A-I      intronic chr20:43617035(+) A-I      intronic chr20:43616970(+) A-I      intronic chr20:43692488(+) A-I      intronic chr20:43675005(+) A-I      intronic chr20:43616936(+) A-I      intronic chr20:43674982(+) A-I      intronic chr20:43674860(+) A-I      intronic chr20:43674841(+) A-I      intronic chr20:43674682(+) A-I      intronic chr20:43674528(+) A-I      intronic chr20:43674470(+) A-I      intronic chr20:43663438(+) A-I      intronic chr20:43663330(+) A-I      intronic chr20:43660471(+) A-I      intronic chr20:43675532(+) A-I      intronic chr20:43660365(+) A-I      intronic chr20:43675523(+) A-I      intronic chr20:43675520(+) A-I      intronic chr20:43675468(+) A-I      intronic chr20:43620445(+) A-I      intronic chr20:43620327(+) A-I      intronic chr20:43659654(+) A-I      intronic chr20:43659583(+) A-I      intronic chr20:43658927(+) A-I      intronic chr20:43658921(+) A-I      intronic chr20:43658912(+) A-I      intronic chr20:43658904(+) A-I      intronic chr20:43647653(+) A-I      intronic chr20:43647508(+) A-I      intronic chr20:43642959(+) A-I      intronic chr20:43642879(+) A-I      intronic chr20:43640816(+) A-I      intronic chr20:43640794(+) A-I      intronic chr20:43640725(+) A-I      intronic chr20:43640697(+) A-I      intronic chr20:43636939(+) A-I      intronic chr20:43636896(+) A-I      intronic chr20:43636861(+) A-I      intronic chr20:43636841(+) A-I      intronic chr20:43636795(+) A-I      intronic chr20:43636049(+) A-I      intronic chr20:43636037(+) A-I      intronic chr20:43635993(+) A-I      intronic chr20:43635982(+) A-I      intronic chr20:43635922(+) A-I      intronic chr20:43634291(+) A-I      intronic chr20:43660384(+) A-I      intronic chr20:43634290(+) A-I      intronic chr20:43634168(+) A-I      intronic chr20:43634120(+) A-I      intronic chr20:43634101(+) A-I      intronic chr20:43634099(+) A-I      intronic chr20:43699265(+) A-I      intronic chr20:43692656(+) A-I      intronic chr20:43634058(+) A-I      intronic chr20:43633688(+) A-I      intronic chr20:43633674(+) A-I      intronic chr20:43633535(+) A-I      intronic chr20:43622569(+) A-I      intronic chr20:43622424(+) A-I      intronic chr20:43621599(+) A-I      intronic chr20:43621584(+) A-I      intronic chr20:43621571(+) A-I      intronic chr20:43621566(+) A-I      intronic chr20:43621502(+) A-I      intronic chr20:43621475(+) A-I      intronic chr20:43621287(+) A-I      intronic chr20:43620540(+) A-I      intronic chr20:43620527(+) A-I      intronic chr20:43620526(+) A-I      intronic chr20:43616922(+) A-I      intronic chr20:43620502(+) A-I      intronic chr20:43706926(+) A-I      3'UTR chr20:43707053(+) A-I      3'UTR chr20:43706233(+) A-I      3'UTR chr20:43707781(+) A-I      3'UTR chr20:43706225(+) A-I      3'UTR chr20:43706921(+) A-I      3'UTR chr20:43706124(+) A-I      3'UTR chr20:43706119(+) A-I      3'UTR chr20:43603314(+) A-I      ncRNA chr20:43707860(+) A-I      3'UTR chr20:43706106(+) A-I      3'UTR chr20:43707037(+) A-I      3'UTR chr20:43707847(+) A-I      3'UTR chr20:43706872(+) A-I      3'UTR chr20:43707817(+) A-I      3'UTR chr20:43706868(+) A-I      3'UTR chr20:43706866(+) A-I      3'UTR chr20:43707798(+) A-I      3'UTR chr20:43706964(+) A-I      3'UTR chr20:43706927(+) A-I      3'UTR chr20:43707749(+) A-I      3'UTR chr20:43707702(+) A-I      3'UTR chr20:43707670(+) A-I      3'UTR chr20:43707658(+) A-I      3'UTR chr20:43612057(+) A-I      intronic chr20:43660467(+) A-I      intronic chr20:43663411(+) A-I      intronic chr20:43640807(+) A-I      intronic chr20:43662468(+) A-I      intronic chr20:43660288(+) A-I      intronic chr20:43620443(+) A-I      intronic chr20:43614008(+) A-I      intronic chr20:43674922(+) A-I      intronic chr20:43674920(+) A-I      intronic chr20:43700434(+) A-I      intronic chr20:43636140(+) A-I      intronic chr20:43673259(+) A-I      intronic chr20:43683098(+) A-I      intronic chr20:43660381(+) A-I      intronic chr20:43634166(+) A-I      intronic chr20:43663478(+) A-I      intronic chr20:43626151(+) A-I      intronic chr20:43655792(+) A-I      intronic chr20:43658848(+) A-I      intronic chr20:43662386(+) A-I      intronic chr20:43675423(+) A-I      intronic chr20:43662338(+) A-I      intronic chr20:43663435(+) A-I      intronic chr20:43635939(+) A-I      intronic chr20:43612108(+) A-I      intronic chr20:43674996(+) A-I      intronic chr20:43612197(+) A-I      intronic chr20:43674961(+) A-I      intronic chr20:43612215(+) A-I      intronic chr20:43674972(+) A-I      intronic chr20:43675061(+) A-I      intronic chr20:43621217(+) A-I      intronic chr20:43663371(+) A-I      intronic chr20:43621394(+) A-I      intronic chr20:43707839(+) A-I      3'UTR chr20:43707790(+) A-I      3'UTR chr20:43707108(+) A-I      3'UTR chr20:43707717(+) A-I      3'UTR chr20:43706947(+) A-I      3'UTR chr20:43706166(+) A-I      3'UTR chr20:43707759(+) A-I      3'UTR chr20:43706098(+) A-I      3'UTR chr20:43707806(+) A-I      3'UTR chr20:43707791(+) A-I      3'UTR chr20:43707699(+) A-I      3'UTR chr20:43707709(+) A-I      3'UTR chr20:43706101(+) A-I      3'UTR chr20:43707758(+) A-I      3'UTR chr20:43706988(+) A-I      3'UTR chr20:43707842(+) A-I      3'UTR chr20:43707669(+) A-I      3'UTR chr20:43707705(+) A-I      3'UTR chr20:43707050(+) A-I      3'UTR chr20:43706951(+) A-I      3'UTR chr20:43707845(+) A-I      3'UTR chr20:43707045(+) A-I      3'UTR chr20:43706063(+) A-I      3'UTR chr20:43706986(+) A-I      3'UTR chr20:43707814(+) A-I      3'UTR chr20:43707735(+) A-I      3'UTR chr20:43706145(+) A-I      3'UTR chr20:43707841(+) A-I      3'UTR chr20:43620433(+) A-I      intronic chr20:43662362(+) A-I      intronic chr20:43663408(+) A-I      intronic chr20:43621281(+) A-I      intronic chr20:43674874(+) A-I      intronic chr20:43674548(+) A-I      intronic chr20:43682928(+) A-I      intronic chr20:43675020(+) A-I      intronic chr20:43663492(+) A-I      intronic chr20:43662321(+) A-I      intronic chr20:43633539(+) A-I      intronic chr20:43612109(+) A-I      intronic chr20:43617036(+) A-I      intronic chr20:43616917(+) A-I      intronic chr20:43635925(+) A-I      intronic chr20:43655956(+) A-I      intronic chr20:43620451(+) A-I      intronic chr20:43663507(+) A-I      intronic chr20:43683125(+) A-I      intronic chr20:43658776(+) A-I      intronic chr20:43633551(+) A-I      intronic chr20:43634142(+) A-I      intronic chr20:43655951(+) A-I      intronic chr20:43674549(+) A-I      intronic chr20:43640866(+) A-I      intronic chr20:43642964(+) A-I      intronic chr20:43636716(+) A-I      intronic chr20:43674631(+) A-I      intronic chr20:43658864(+) A-I      intronic chr20:43674965(+) A-I      intronic chr20:43631698(+) A-I      intronic chr20:43700639(+) A-I      intronic chr20:43636796(+) A-I      intronic chr20:43632854(+) A-I      intronic chr20:43612196(+) A-I      intronic chr20:43640927(+) A-I      intronic chr20:43675060(+) A-I      intronic chr20:43621384(+) A-I      intronic chr20:43611053(+) A-I      intronic chr20:43622400(+) A-I      intronic chr20:43674587(+) A-I      intronic chr20:43640806(+) A-I      intronic chr20:43620525(+) A-I      intronic chr20:43674888(+) A-I      intronic chr20:43621575(+) A-I      intronic chr20:43634178(+) A-I      intronic chr20:43700640(+) A-I      intronic chr20:43611988(+) A-I      intronic chr20:43617022(+) A-I      intronic chr20:43636789(+) A-I      intronic chr20:43612207(+) A-I      intronic chr20:43616901(+) A-I      intronic chr20:43660279(+) A-I      intronic chr20:43612165(+) A-I      intronic chr20:43699409(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STK4	chr20:43706870(+) A-I exon 3'UTR    15342557 chr20:43706878(+) A-I exon 3'UTR    15342557 chr20:43706940(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr20:43706946(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr20:43706947(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr20:43706951(+) A-I exon 3'UTR    15342557   //15258596 chr20:43707013(+) A-I exon 3'UTR    15342557   //15258596 chr20:43707108(+) A-I exon 3'UTR    15258596 chr20:43707709(+) A-I exon 3'UTR    15342557   //22327324 chr20:43707736(+) A-I exon 3'UTR    15342557   //22327324 chr20:43707758(+) A-I exon 3'UTR    15342557   //15258596 chr20:43707759(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr20:43707776(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr20:43707785(+) A-I exon 3'UTR    15342557   //22327324 chr20:43707790(+) A-I exon 3'UTR    15258596 chr20:43707842(+) A-I exon 3'UTR    15342557 chr20:43688119(+) A-I intron -    22327324 chr20:43688123(+) A-I intron -    22327324 chr20:43688210(+) A-I intron -    22327324 chr20:43706098(+) A-I intron -    22327324 chr20:43706101(+) A-I intron -    22327324 chr20:43706988(+) A-I intron -    22327324 chr20:43707669(+) A-I intron -    22327324 chr20:43707771(+) A-I intron -    22327324 chr20:43707845(+) A-I intron -    22327324 chr20:43688117(+) A-G intron -    22484847 chr20:43688119(+) A-G intron -    22484847 chr20:43688123(+) A-G intron -    22484847 chr20:43688196(+) A-G intron -    22484847 chr20:43688202(+) A-G intron -    22484847 chr20:43688210(+) A-G intron -    22484847 chr20:43688220(+) A-G intron -    22484847 chr20:43689992(+) A-G intron -    22484847 chr20:43689996(+) A-G intron -    22484847 chr20:43690072(+) A-G intron -    22484847 chr20:43690096(+) A-G intron -    22484847 chr20:43690099(+) A-G intron -    22484847 chr20:43690100(+) A-G intron -    22484847 chr20:43694633(+) A-G intron -    22484847 chr20:43612108(+) A-G intron -    22484847 chr20:43614008(+) A-G intron -    22484847 chr20:43614012(+) A-G intron -    22484847 chr20:43663371(+) A-G intron -    22484847 chr20:43663408(+) A-G intron -    22484847 chr20:43706098(+) A-G intron -    22484847 chr20:43706870(+) A-G intron -    22484847 chr20:43706878(+) A-G intron -    22484847 chr20:43706940(+) A-G intron -    22484847 chr20:43706946(+) A-G intron -    22484847 chr20:43706947(+) A-G intron -    22484847 chr20:43706951(+) A-G intron -    22484847 chr20:43706988(+) A-G intron -    22484847 chr20:43707669(+) A-G intron -    22484847 chr20:43707699(+) A-G intron -    22484847 chr20:43707709(+) A-G intron -    22484847 chr20:43707736(+) A-G intron -    22484847 chr20:43707759(+) A-G intron -    22484847 chr20:43707771(+) A-G intron -    22484847 chr20:43707776(+) A-G intron -    22484847 chr20:43707814(+) A-G intron -    22484847 chr20:43707839(+) A-G intron -    22484847 chr20:43707842(+) A-G intron -    22484847 chr20:43707845(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STK4	chr20:43595231-43595232(+) m6A CDS//exon       25456834//24981863 chr20:43600765-43600766(+) m1A 5'UTR//CDS//exon       26863196 chr20:43603034-43603035(+) m6A 3'UTR//exon//intron       22608085 chr20:43603076-43603077(+) m6A 3'UTR//intron       22608085 chr20:43603100-43603101(+) m6A 3'UTR//intron       22608085 chr20:43603451-43603452(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr20:43603496-43603497(+) m6A 3'UTR//intron       24284625//24209618//24981863//22575960//22608085 chr20:43603577-43603578(+) m6A 3'UTR//intron       24284625//22608085 chr20:43604099-43604100(+) m6A 3'UTR//intron       22608085 chr20:43604156-43604157(+) m6A 3'UTR//intron       22608085 chr20:43604166-43604167(+) m6A 3'UTR//intron       22608085 chr20:43604203-43604204(+) m6A 3'UTR//intron       22608085 chr20:43629075-43629076(+) m6A CDS       24981863 chr20:43629103-43629104(+) m6A CDS       24981863 chr20:43629138-43629139(+) m6A CDS       24981863 chr20:43629156-43629157(+) m6A CDS       24981863 chr20:43629984-43629985(+) m6A CDS       24981863 chr20:43653624-43653625(+) m6A CDS       24981863 chr20:43653641-43653642(+) m6A CDS       24981863 chr20:43653665-43653666(+) m6A CDS       24981863 chr20:43653682-43653683(+) m6A CDS       24981863 chr20:43653760-43653761(+) m6A CDS       24284625 chr20:43681729-43681730(+) m6A CDS//intron       24284625 chr20:43681740-43681741(+) m6A CDS//intron       24284625 chr20:43681757-43681758(+) m6A CDS//intron       24284625 chr20:43681784-43681785(+) m6A CDS//intron       24284625//25456834//22608085 chr20:43681813-43681814(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr20:43703670-43703671(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085 chr20:43703680-43703681(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085 chr20:43703707-43703708(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr20:43703809-43703810(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr20:43703936-43703937(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr20:43704065-43704066(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr20:43704074-43704075(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr20:43704080-43704081(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr20:43704163-43704164(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:43704297-43704298(+) m6A 3'UTR       24981863 chr20:43704312-43704313(+) m6A 3'UTR       24981863 chr20:43704626-43704627(+) m6A 3'UTR       24284625//24981863//22608085 chr20:43704644-43704645(+) m6A 3'UTR       24284625//24981863//22608085 chr20:43704655-43704656(+) m6A 3'UTR       24284625//24981863//22608085 chr20:43704662-43704663(+) m6A 3'UTR       24284625//24981863//22608085 chr20:43705910-43705911(+) Tm 3'UTR       - chr20:43706867-43706868(+) m6A 3'UTR       - chr20:43707350-43707351(+) m6A 3'UTR       26404942 chr20:43707595-43707596(+) m6A 3'UTR       24981863//26404942//27773535 chr20:43707687-43707688(+) m6A 3'UTR       24981863 chr20:43708443-43708444(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374b-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	STK4	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374b-3p
Interactor2: STK4

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.