Detail Information

Basic Information:


  VIRBase ID:  

HHID00068086

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-5p:           NHLRC2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-374b-5p NHLRC2
miRBase
Accession/Entrez ID		 MIMAT0004955 374354
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - FINCA

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NHLRC2
chr10:115675649(+) A-I      3'UTR
chr10:115675599(+) A-I      3'UTR
chr10:115675642(+) A-I      3'UTR
chr10:115627361(+) A-I      intronic
chr10:115675657(+) A-I      3'UTR
chr10:115675663(+) A-I      3'UTR
chr10:115675665(+) A-I      3'UTR
chr10:115624907(+) A-I      intronic
chr10:115624765(+) A-I      intronic
chr10:115624225(+) A-I      intronic
chr10:115624336(+) A-I      intronic
chr10:115624248(+) A-I      intronic
chr10:115624915(+) A-I      intronic
chr10:115624301(+) A-I      intronic
chr10:115624270(+) A-I      intronic
chr10:115624838(+) A-I      intronic
chr10:115624850(+) A-I      intronic
chr10:115648807(+) A-I      intronic
chr10:115624809(+) A-I      intronic
chr10:115624303(+) A-I      intronic
chr10:115624397(+) A-I      intronic
chr10:115624388(+) A-I      intronic
chr10:115624821(+) A-I      intronic
chr10:115647731(+) A-I      intronic
chr10:115621736(+) A-I      intronic
chr10:115624281(+) A-I      intronic
chr10:115624295(+) A-I      intronic
chr10:115624363(+) A-I      intronic
chr10:115621735(+) A-I      intronic
chr10:115624848(+) A-I      intronic
chr10:115624732(+) A-I      intronic
chr10:115624201(+) A-I      intronic
chr10:115624335(+) A-I      intronic
chr10:115622644(+) A-I      intronic
chr10:115624271(+) A-I      intronic
chr10:115666584(+) A-I      intronic
chr10:115647807(+) A-I      intronic
chr10:115666560(+) A-I      intronic
chr10:115675443(+) A-I      3'UTR
chr10:115628720(+) A-I      intronic
chr10:115631057(+) A-I      intronic
chr10:115628722(+) A-I      intronic
chr10:115628689(+) A-I      intronic
chr10:115675666(+) A-I      3'UTR
chr10:115670145(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NHLRC2
chr10:115628689(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NHLRC2
chr10:115614440-115614441(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr10:115614455-115614456(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr10:115614470-115614471(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr10:115614549-115614550(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr10:115614557-115614558(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr10:115614586-115614587(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22608085
chr10:115614629-115614630(+) m6A 5'UTR//exon       24209618//25456834//22608085
chr10:115614685-115614686(+) m6A CDS//exon       24209618
chr10:115614734-115614735(+) m6A CDS//exon       -
chr10:115614782-115614783(+) m6A CDS//exon       24284625
chr10:115618301-115618302(+) m6A CDS//exon       24284625
chr10:115618311-115618312(+) m6A CDS//exon       24284625
chr10:115618468-115618469(+) m6A exon//intron       24981863
chr10:115636415-115636416(+) m6A CDS       24284625//24981863//22575960//22608085
chr10:115636454-115636455(+) m6A CDS       24284625//24981863//22575960//22608085
chr10:115636465-115636466(+) m6A CDS       24284625//24981863//22575960//22608085
chr10:115636493-115636494(+) m6A CDS       24284625//24981863//22575960//22608085
chr10:115636546-115636547(+) m6A CDS       24284625//24209618//24981863//22608085
chr10:115636583-115636584(+) m6A CDS       24284625//24981863//22608085
chr10:115636642-115636643(+) m6A CDS       24284625//24981863//22608085
chr10:115636672-115636673(+) m6A CDS       24284625//24981863//22608085
chr10:115636679-115636680(+) m6A CDS       24284625//24981863//22608085
chr10:115636712-115636713(+) m6A CDS       24981863//22608085
chr10:115644132-115644133(+) m6A CDS       24981863
chr10:115664631-115664632(+) m6A CDS       24284625//24981863
chr10:115664638-115664639(+) m6A CDS       24284625//24981863
chr10:115664649-115664650(+) m6A CDS       24284625//24981863//22608085
chr10:115664707-115664708(+) m6A CDS       24284625//24209618//24981863//22608085
chr10:115664721-115664722(+) m6A CDS       24284625//24209618//24981863//22608085
chr10:115664732-115664733(+) m6A CDS       24284625//24209618//24981863//22608085
chr10:115668060-115668061(+) m6A CDS       24284625//24209618//24981863//22608085
chr10:115668086-115668087(+) m6A CDS       24284625//24209618//24981863//22608085
chr10:115668188-115668189(+) m6A CDS       24284625
chr10:115668373-115668374(+) m6A 3'UTR       24981863
chr10:115668951-115668952(+) m6A 3'UTR       24981863//22608085
chr10:115668972-115668973(+) m6A 3'UTR       24981863//22608085
chr10:115668989-115668990(+) m6A 3'UTR       24981863//22608085
chr10:115669076-115669077(+) m6A 3'UTR       24981863//22608085
chr10:115669084-115669085(+) m6A 3'UTR       24981863//22608085
chr10:115674950-115674951(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-374b-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Human mast cell line (HMC-1)     24009880
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Neural progenitor cells     21363885
NHLRC2
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-374b-5p
Sensorad 99342 Drug sensitive
Pyrazolo[1,5-b]pyridazine deriv. 40 6539382 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Antibiotic 1907-VIII 5477807 Drug sensitive
Artelasticin 5471311 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
8-Hydroxymanzamine A 5270765 Drug sensitive
Trichopolyn 431962 Drug sensitive
Rogiolol 402519 Drug sensitive
2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
7-Chloro-1-methyl-phenothiazone 369386 Drug sensitive
6-(5-Tetrahydropyranylossi-1-pentynyl)-2(2H)-pyranone 24203140 Drug sensitive
Victoria Blue R 16599 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug sensitive
Triethyltin chloride 13820 Drug sensitive
12-Iminodaunorubicin hcl 135539784 Drug sensitive
1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive
leucinostatine d - Drug sensitive
streptorubrin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-374b-5p
Gemcitabine 60750 Drug interaction    RC00007458
D-Glucose 5793 Drug interaction    RC00007457
Cholecalciferol 5280795 Drug interaction    RC00007461
Docosahexaenoic acid 445580 Drug interaction    RC00007459
5-Fluorouracil 3385 Drug interaction    RC00007456
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007455
Tamoxifen 2733526 Drug interaction    RC00007460
Marine fungal metabolite 1386A - Drug interaction    RC00007462

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-374b-5p
Interactor2: NHLRC2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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