Detail Information

Basic Information:


  VIRBase ID:  

HHID00068070

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-5p:           PARD6B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-374b-5p PARD6B
miRBase
Accession/Entrez ID		 MIMAT0004955 84612
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PAR6B

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PARD6B
chr20:49357637(+) A-I      intronic
chr20:49353437(+) A-I      intronic
chr20:49353395(+) A-I      intronic
chr20:49351511(+) A-I      intronic
chr20:49351320(+) A-I      intronic
chr20:49355823(+) A-I      intronic
chr20:49351024(+) A-I      intronic
chr20:49355822(+) A-I      intronic
chr20:49351022(+) A-I      intronic
chr20:49351425(+) A-I      intronic
chr20:49372363(+) A-I      intronic
chr20:49365181(+) A-I      intronic
chr20:49364638(+) A-I      intronic
chr20:49364614(+) A-I      intronic
chr20:49362305(+) A-I      intronic
chr20:49360305(+) A-I      intronic
chr20:49360170(+) A-I      intronic
chr20:49358717(+) A-I      intronic
chr20:49358660(+) A-I      intronic
chr20:49358641(+) A-I      intronic
chr20:49358629(+) A-I      intronic
chr20:49355864(+) A-I      intronic
chr20:49351454(+) A-I      intronic
chr20:49355837(+) A-I      intronic
chr20:49372439(+) A-I      intronic
chr20:49372444(+) A-I      intronic
chr20:49360315(+) A-I      intronic
chr20:49355831(+) A-I      intronic
chr20:49355819(+) A-I      intronic
chr20:49355807(+) A-I      intronic
chr20:49353418(+) A-I      intronic
chr20:49353364(+) A-I      intronic
chr20:49353312(+) A-I      intronic
chr20:49353299(+) A-I      intronic
chr20:49353291(+) A-I      intronic
chr20:49351632(+) A-I      intronic
chr20:49351608(+) A-I      intronic
chr20:49351607(+) A-I      intronic
chr20:49372434(+) A-I      intronic
chr20:49360214(+) A-I      intronic
chr20:49351293(+) A-I      intronic
chr20:49353496(+) A-I      intronic
chr20:49360217(+) A-I      intronic
chr20:49351556(+) A-I      intronic
chr20:49370830(+) A-I      intronic
chr20:49350945(+) A-I      intronic
chr20:49351567(+) A-I      intronic
chr20:49353487(+) A-I      intronic
chr20:49360237(+) A-I      intronic
chr20:49357772(+) A-I      intronic
chr20:49350937(+) A-I      intronic
chr20:49365176(+) A-I      intronic
chr20:49365786(+) A-I      intronic
chr20:49349951(+) A-I      intronic
chr20:49368157(+) A-I      3'UTR
chr20:49364766(+) A-I      intronic
chr20:49365603(+) A-I      intronic
chr20:49360781(+) A-I      intronic
chr20:49362318(+) A-I      intronic
chr20:49365356(+) A-I      intronic
chr20:49353308(+) A-I      intronic
chr20:49365702(+) A-I      intronic
chr20:49365291(+) A-I      intronic
chr20:49365349(+) A-I      intronic
chr20:49351501(+) A-I      intronic
chr20:49362176(+) A-I      intronic
chr20:49349776(+) A-I      intronic
chr20:49361809(+) A-I      intronic
chr20:49360171(+) A-I      intronic
chr20:49360791(+) A-I      intronic
chr20:49365721(+) A-I      intronic
chr20:49355374(+) A-I      intronic
chr20:49358764(+) A-I      intronic
chr20:49351566(+) A-I      intronic
chr20:49372457(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PARD6B
chr20:49349747(+) A-I intron -    21960545
chr20:49351017(+) A-I intron -    21960545
chr20:49351022(+) A-I intron -    21960545
chr20:49351241(+) A-I intron -    21960545
chr20:49351293(+) A-I intron -    21960545
chr20:49351567(+) A-I intron -    21960545
chr20:49355420(+) A-I intron -    21960545
chr20:49362282(+) A-I intron -    21960545
chr20:49362305(+) A-I intron -    21960545
chr20:49362306(+) A-I intron -    21960545
chr20:49365291(+) A-I intron -    21960545
chr20:49365349(+) A-G intron -    22484847
chr20:49365689(+) G-C intron -    22484847
chr20:49365702(+) A-G intron -    22484847
chr20:49365721(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PARD6B
chr20:49348327-49348328(+) m6A CDS       -
chr20:49354434-49354435(+) m6A CDS       22608085
chr20:49354517-49354518(+) m6A CDS       24981863//22608085
chr20:49354529-49354530(+) m6A CDS       24981863//22608085
chr20:49366204-49366205(+) m6A CDS//intron       24284625//24981863//22608085
chr20:49366225-49366226(+) m6A CDS//intron       24284625//24981863//22608085
chr20:49366318-49366319(+) m6A CDS//intron       24284625//24981863//22608085
chr20:49366325-49366326(+) m6A CDS//intron       24284625//24981863//22608085
chr20:49366406-49366407(+) m6A CDS//intron       24284625//24981863//27773535//22608085
chr20:49366526-49366527(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085
chr20:49366603-49366604(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085
chr20:49366646-49366647(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085
chr20:49366654-49366655(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085
chr20:49366678-49366679(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085
chr20:49366686-49366687(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085
chr20:49366748-49366749(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085
chr20:49366774-49366775(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085
chr20:49366804-49366805(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085
chr20:49366895-49366896(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085
chr20:49366954-49366955(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085
chr20:49366968-49366969(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085
chr20:49366988-49366989(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085
chr20:49367007-49367008(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085
chr20:49367026-49367027(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085
chr20:49367066-49367067(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085
chr20:49367192-49367193(+) m6A 3'UTR//intron       24981863//27773535//22608085
chr20:49367226-49367227(+) m6A 3'UTR//intron       24981863//22608085
chr20:49367307-49367308(+) m6A 3'UTR//intron       22608085
chr20:49367320-49367321(+) m6A 3'UTR//intron       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-374b-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Human mast cell line (HMC-1)     24009880
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Neural progenitor cells     21363885
PARD6B
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-374b-5p
Sensorad 99342 Drug sensitive
Pyrazolo[1,5-b]pyridazine deriv. 40 6539382 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Antibiotic 1907-VIII 5477807 Drug sensitive
Artelasticin 5471311 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
8-Hydroxymanzamine A 5270765 Drug sensitive
Trichopolyn 431962 Drug sensitive
Rogiolol 402519 Drug sensitive
2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
7-Chloro-1-methyl-phenothiazone 369386 Drug sensitive
6-(5-Tetrahydropyranylossi-1-pentynyl)-2(2H)-pyranone 24203140 Drug sensitive
Victoria Blue R 16599 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug sensitive
Triethyltin chloride 13820 Drug sensitive
12-Iminodaunorubicin hcl 135539784 Drug sensitive
1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive
leucinostatine d - Drug sensitive
streptorubrin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-374b-5p
Gemcitabine 60750 Drug interaction    RC00007458
D-Glucose 5793 Drug interaction    RC00007457
Cholecalciferol 5280795 Drug interaction    RC00007461
Docosahexaenoic acid 445580 Drug interaction    RC00007459
5-Fluorouracil 3385 Drug interaction    RC00007456
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007455
Tamoxifen 2733526 Drug interaction    RC00007460
Marine fungal metabolite 1386A - Drug interaction    RC00007462

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-374b-5p
Interactor2: PARD6B

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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