Detail Information

Basic Information:


  VIRBase ID:  

HHID00068040

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-5p:           DCTN4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-374b-5p DCTN4
miRBase
Accession/Entrez ID		 MIMAT0004955 51164
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DYN4//P62

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DCTN4
chr5:150093209(-) A-I      intronic
chr5:150093185(-) A-I      intronic
chr5:150093179(-) A-I      intronic
chr5:150091922(-) A-I      intronic
chr5:150096369(-) A-I      intronic
chr5:150096333(-) A-I      intronic
chr5:150096435(-) A-I      intronic
chr5:150108506(-) A-I      intronic
chr5:150108528(-) A-I      intronic
chr5:150113581(-) A-I      intronic
chr5:150091784(-) A-I      intronic
chr5:150113605(-) A-I      intronic
chr5:150091759(-) A-I      intronic
chr5:150113622(-) A-I      intronic
chr5:150091749(-) A-I      intronic
chr5:150091707(-) A-I      intronic
chr5:150094103(-) A-I      intronic
chr5:150121276(-) A-I      intronic
chr5:150095733(-) A-I      intronic
chr5:150095611(-) A-I      intronic
chr5:150095564(-) A-I      intronic
chr5:150095552(-) A-I      intronic
chr5:150134439(-) A-I      intronic
chr5:150094105(-) A-I      intronic
chr5:150134343(-) A-I      intronic
chr5:150096398(-) A-I      intronic
chr5:150134399(-) A-I      intronic
chr5:150129115(-) A-I      intronic
chr5:150121290(-) A-I      intronic
chr5:150121212(-) A-I      intronic
chr5:150121081(-) A-I      intronic
chr5:150120651(-) A-I      intronic
chr5:150120645(-) A-I      intronic
chr5:150109295(-) A-I      intronic
chr5:150108703(-) A-I      intronic
chr5:150108699(-) A-I      intronic
chr5:150108665(-) A-I      intronic
chr5:150108660(-) A-I      intronic
chr5:150095518(-) A-I      intronic
chr5:150095539(-) A-I      intronic
chr5:150095543(-) A-I      intronic
chr5:150095623(-) A-I      intronic
chr5:150095747(-) A-I      intronic
chr5:150096230(-) A-I      intronic
chr5:150096300(-) A-I      intronic
chr5:150095635(-) A-I      intronic
chr5:150095636(-) A-I      intronic
chr5:150095638(-) A-I      intronic
chr5:150096424(-) A-I      intronic
chr5:150096256(-) A-I      intronic
chr5:150108469(-) A-I      intronic
chr5:150093602(-) A-I      intronic
chr5:150093551(-) A-I      intronic
chr5:150108470(-) A-I      intronic
chr5:150095529(-) A-I      intronic
chr5:150096455(-) A-I      intronic
chr5:150104657(-) A-I      intronic
chr5:150104706(-) A-I      intronic
chr5:150108568(-) A-I      intronic
chr5:150108555(-) A-I      intronic
chr5:150108497(-) A-I      intronic
chr5:150093516(-) A-I      intronic
chr5:150093487(-) A-I      intronic
chr5:150093233(-) A-I      intronic
chr5:150134468(-) A-I      intronic
chr5:150096471(-) A-I      intronic
chr5:150108723(-) A-I      intronic
chr5:150097013(-) A-I      intronic
chr5:150108500(-) A-I      intronic
chr5:150095639(-) A-I      intronic
chr5:150095627(-) A-I      intronic
chr5:150105532(-) A-I      intronic
chr5:150108601(-) A-I      intronic
chr5:150093550(-) A-I      intronic
chr5:150093068(-) A-I      intronic
chr5:150135774(-) A-I      intronic
chr5:150094148(-) A-I      intronic
chr5:150093108(-) A-I      intronic
chr5:150093596(-) A-I      intronic
chr5:150109281(-) A-I      intronic
chr5:150091165(-) A-I      intronic
chr5:150096277(-) A-I      intronic
chr5:150121085(-) A-I      intronic
chr5:150134270(-) A-I      intronic
chr5:150093170(-) A-I      intronic
chr5:150108532(-) A-I      intronic
chr5:150093060(-) A-I      intronic
chr5:150113606(-) A-I      intronic
chr5:150135780(-) A-I      intronic
chr5:150093513(-) A-I      intronic
chr5:150113500(-) A-I      intronic
chr5:150108502(-) A-I      intronic
chr5:150113642(-) A-I      intronic
chr5:150134511(-) A-I      intronic
chr5:150096950(-) A-I      intronic
chr5:150132611(-) A-I      intronic
chr5:150135715(-) A-I      intronic
chr5:150093154(-) A-I      intronic
chr5:150108505(-) A-I      intronic
chr5:150093593(-) A-I      intronic
chr5:150121111(-) A-I      intronic
chr5:150134430(-) A-I      intronic
chr5:150093579(-) A-I      intronic
chr5:150113523(-) A-I      intronic
chr5:150093641(-) A-I      intronic
chr5:150093597(-) A-I      intronic
chr5:150134354(-) A-I      intronic
chr5:150095631(-) A-I      intronic
chr5:150093676(-) A-I      intronic
chr5:150120658(-) A-I      intronic
chr5:150132598(-) A-I      intronic
chr5:150096237(-) A-I      intronic
chr5:150093144(-) A-I      intronic
chr5:150113589(-) A-I      intronic
chr5:150134442(-) A-I      intronic
chr5:150120725(-) A-I      intronic
chr5:150096312(-) A-I      intronic
chr5:150121238(-) A-I      intronic
chr5:150113624(-) A-I      intronic
chr5:150095722(-) A-I      intronic
chr5:150109322(-) A-I      intronic
chr5:150113573(-) A-I      intronic
chr5:150121072(-) A-I      intronic
chr5:150091285(-) A-I      intronic
chr5:150134449(-) A-I      intronic
chr5:150093531(-) A-I      intronic
chr5:150121262(-) A-I      intronic
chr5:150094077(-) A-I      intronic
chr5:150108564(-) A-I      intronic
chr5:150120721(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DCTN4
chr5:150106698(-) A-I intron -    22327324
chr5:150106660(-) A-I intron -    21960545
chr5:150121135(-) A-I intron -    21960545
chr5:150091733(-) G-A intron -    22484847
chr5:150093108(-) A-G intron -    22484847
chr5:150093513(-) A-G intron -    22484847
chr5:150093555(-) A-G intron -    22484847
chr5:150093593(-) A-G intron -    22484847
chr5:150093596(-) A-G intron -    22484847
chr5:150093597(-) A-G intron -    22484847
chr5:150093641(-) A-G intron -    22484847
chr5:150093676(-) A-G intron -    22484847
chr5:150094148(-) A-G intron -    22484847
chr5:150095627(-) A-G intron -    22484847
chr5:150095732(-) A-G intron -    22484847
chr5:150096237(-) A-G intron -    22484847
chr5:150096277(-) A-G intron -    22484847
chr5:150096312(-) A-G intron -    22484847
chr5:150096314(-) A-G intron -    22484847
chr5:150096317(-) A-G intron -    22484847
chr5:150096359(-) A-G intron -    22484847
chr5:150096405(-) A-G intron -    22484847
chr5:150096950(-) A-G intron -    22484847
chr5:150096989(-) A-G intron -    22484847
chr5:150100200(-) A-G intron -    22484847
chr5:150100237(-) T-C intron -    22484847
chr5:150107360(-) G-T intron -    22484847
chr5:150113500(-) A-G intron -    22484847
chr5:150113561(-) A-G intron -    22484847
chr5:150113589(-) A-G intron -    22484847
chr5:150113624(-) A-G intron -    22484847
chr5:150113642(-) A-G intron -    22484847
chr5:150120659(-) A-G intron -    22484847
chr5:150120721(-) A-G intron -    22484847
chr5:150120725(-) A-G intron -    22484847
chr5:150121135(-) A-G intron -    22484847
chr5:150132611(-) A-G intron -    22484847
chr5:150134430(-) A-G intron -    22484847
chr5:150134438(-) G-A intron -    22484847
chr5:150135715(-) A-G intron -    22484847
chr5:150135764(-) A-G intron -    22484847
chr5:150135774(-) A-G intron -    22484847
chr5:150135780(-) A-G intron -    22484847
chr5:150106697(-) A-G intron -    22484847
chr5:150106698(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DCTN4
chr5:150090389-150090390(-) m6A 3'UTR       24981863//27773535
chr5:150090479-150090480(-) m6A 3'UTR       24284625//24981863//27773535
chr5:150090550-150090551(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr5:150090664-150090665(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr5:150090679-150090680(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr5:150090737-150090738(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr5:150090769-150090770(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr5:150090813-150090814(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr5:150112968-150112969(-) m6A 3'UTR//CDS//exon       -
chr5:150113032-150113033(-) m6A 3'UTR//CDS//exon       -
chr5:150121699-150121700(-) m6A 3'UTR//5'UTR//CDS//exon//intron       27773535
chr5:150122435-150122436(-) m6A 5'UTR//intron       27773535
chr5:150133051-150133052(-) m6A 3'UTR//CDS//exon       24981863
chr5:150133124-150133125(-) m6A 3'UTR//CDS//exon       24981863
chr5:150135100-150135101(-) m6A CDS//exon//intron       27773535
chr5:150135992-150135993(-) m6A CDS//exon       27773535
chr5:150136044-150136045(-) m6A 5'UTR//CDS//exon       27773535
chr5:150137501-150137502(-) m6A 5'UTR//exon//intron       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-374b-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Human mast cell line (HMC-1)     24009880
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Neural progenitor cells     21363885
DCTN4
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-374b-5p
Sensorad 99342 Drug sensitive
Pyrazolo[1,5-b]pyridazine deriv. 40 6539382 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Antibiotic 1907-VIII 5477807 Drug sensitive
Artelasticin 5471311 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
8-Hydroxymanzamine A 5270765 Drug sensitive
Trichopolyn 431962 Drug sensitive
Rogiolol 402519 Drug sensitive
2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
7-Chloro-1-methyl-phenothiazone 369386 Drug sensitive
6-(5-Tetrahydropyranylossi-1-pentynyl)-2(2H)-pyranone 24203140 Drug sensitive
Victoria Blue R 16599 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug sensitive
Triethyltin chloride 13820 Drug sensitive
12-Iminodaunorubicin hcl 135539784 Drug sensitive
1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive
leucinostatine d - Drug sensitive
streptorubrin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-374b-5p
Gemcitabine 60750 Drug interaction    RC00007458
D-Glucose 5793 Drug interaction    RC00007457
Cholecalciferol 5280795 Drug interaction    RC00007461
Docosahexaenoic acid 445580 Drug interaction    RC00007459
5-Fluorouracil 3385 Drug interaction    RC00007456
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007455
Tamoxifen 2733526 Drug interaction    RC00007460
Marine fungal metabolite 1386A - Drug interaction    RC00007462

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-374b-5p
Interactor2: DCTN4

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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