Basic Information:

  VIRBase ID:  

HHID00068025

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-5p:  MIMAT0004955          SWAP70:  NM_001297714     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374b-5p	SWAP70
miRBase Accession/Entrez ID	MIMAT0004955	23075
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSPC321//SWAP-70

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SWAP70	chr11:9716720(+) A-I      intronic chr11:9743205(+) A-I      intronic chr11:9743168(+) A-I      intronic chr11:9724203(+) A-I      intronic chr11:9743203(+) A-I      intronic chr11:9743204(+) A-I      intronic chr11:9743212(+) A-I      intronic chr11:9743148(+) A-I      intronic chr11:9721252(+) A-I      intronic chr11:9721250(+) A-I      intronic chr11:9721245(+) A-I      intronic chr11:9721243(+) A-I      intronic chr11:9721173(+) A-I      intronic chr11:9721169(+) A-I      intronic chr11:9721128(+) A-I      intronic chr11:9719092(+) A-I      intronic chr11:9719077(+) A-I      intronic chr11:9719039(+) A-I      intronic chr11:9718969(+) A-I      intronic chr11:9742546(+) A-I      intronic chr11:9718923(+) A-I      intronic chr11:9718503(+) A-I      intronic chr11:9716761(+) A-I      intronic chr11:9696625(+) A-I      intronic chr11:9724126(+) A-I      intronic chr11:9696097(+) A-I      intronic chr11:9716710(+) A-I      intronic chr11:9716626(+) A-I      intronic chr11:9696076(+) A-I      intronic chr11:9716660(+) A-I      intronic chr11:9716616(+) A-I      intronic chr11:9712747(+) A-I      intronic chr11:9766332(+) A-I      intronic chr11:9723061(+) A-I      intronic chr11:9763536(+) A-I      intronic chr11:9712739(+) A-I      intronic chr11:9712704(+) A-I      intronic chr11:9712674(+) A-I      intronic chr11:9712665(+) A-I      intronic chr11:9711972(+) A-I      intronic chr11:9711941(+) A-I      intronic chr11:9711926(+) A-I      intronic chr11:9711857(+) A-I      intronic chr11:9704809(+) A-I      intronic chr11:9732691(+) A-I      intronic chr11:9704783(+) A-I      intronic chr11:9704271(+) A-I      intronic chr11:9696567(+) A-I      intronic chr11:9696498(+) A-I      intronic chr11:9696334(+) A-I      intronic chr11:9696300(+) A-I      intronic chr11:9696146(+) A-I      intronic chr11:9696009(+) A-I      intronic chr11:9696007(+) A-I      intronic chr11:9695991(+) A-I      intronic chr11:9695710(+) A-I      intronic chr11:9695631(+) A-I      intronic chr11:9692562(+) A-I      intronic chr11:9692561(+) A-I      intronic chr11:9692507(+) A-I      intronic chr11:9692499(+) A-I      intronic chr11:9692474(+) A-I      intronic chr11:9692467(+) A-I      intronic chr11:9691528(+) A-I      intronic chr11:9691460(+) A-I      intronic chr11:9691436(+) A-I      intronic chr11:9691039(+) A-I      intronic chr11:9690977(+) A-I      intronic chr11:9749052(+) A-I      intronic chr11:9747033(+) A-I      intronic chr11:9690876(+) A-I      intronic chr11:9690814(+) A-I      intronic chr11:9747302(+) A-I      intronic chr11:9687819(+) A-I      intronic chr11:9687758(+) A-I      intronic chr11:9719104(+) A-I      intronic chr11:9694110(+) A-I      intronic chr11:9704673(+) A-I      intronic chr11:9704786(+) A-I      intronic chr11:9718531(+) A-I      intronic chr11:9747027(+) A-I      intronic chr11:9721201(+) A-I      intronic chr11:9734057(+) A-I      intronic chr11:9765649(+) A-I      intronic chr11:9734026(+) A-I      intronic chr11:9721130(+) A-I      intronic chr11:9766200(+) A-I      intronic chr11:9721289(+) A-I      intronic chr11:9764064(+) A-I      intronic chr11:9764050(+) A-I      intronic chr11:9764049(+) A-I      intronic chr11:9763904(+) A-I      intronic chr11:9759349(+) A-I      intronic chr11:9759345(+) A-I      intronic chr11:9759292(+) A-I      intronic chr11:9759267(+) A-I      intronic chr11:9770923(+) A-I      intronic chr11:9766406(+) A-I      intronic chr11:9766371(+) A-I      intronic chr11:9759262(+) A-I      intronic chr11:9759257(+) A-I      intronic chr11:9691413(+) A-I      intronic chr11:9766335(+) A-I      intronic chr11:9759234(+) A-I      intronic chr11:9766308(+) A-I      intronic chr11:9766299(+) A-I      intronic chr11:9766296(+) A-I      intronic chr11:9766294(+) A-I      intronic chr11:9747393(+) A-I      intronic chr11:9766293(+) A-I      intronic chr11:9747391(+) A-I      intronic chr11:9766290(+) A-I      intronic chr11:9746975(+) A-I      intronic chr11:9766279(+) A-I      intronic chr11:9741016(+) A-I      intronic chr11:9740702(+) A-I      intronic chr11:9722818(+) A-I      intronic chr11:9740697(+) A-I      intronic chr11:9740482(+) A-I      intronic chr11:9734076(+) A-I      intronic chr11:9734059(+) A-I      intronic chr11:9766208(+) A-I      intronic chr11:9740536(+) A-I      intronic chr11:9766205(+) A-I      intronic chr11:9734040(+) A-I      intronic chr11:9765716(+) A-I      intronic chr11:9734018(+) A-I      intronic chr11:9704933(+) A-I      intronic chr11:9726140(+) A-I      intronic chr11:9726021(+) A-I      intronic chr11:9765708(+) A-I      intronic chr11:9726006(+) A-I      intronic chr11:9726005(+) A-I      intronic chr11:9765694(+) A-I      intronic chr11:9724110(+) A-I      intronic chr11:9724059(+) A-I      intronic chr11:9704731(+) A-I      intronic chr11:9765675(+) A-I      intronic chr11:9740516(+) A-I      intronic chr11:9724018(+) A-I      intronic chr11:9722982(+) A-I      intronic chr11:9722953(+) A-I      intronic chr11:9721342(+) A-I      intronic chr11:9721282(+) A-I      intronic chr11:9765651(+) A-I      intronic chr11:9721272(+) A-I      intronic chr11:9716655(+) A-I      intronic chr11:9721256(+) A-I      intronic chr11:9771773(+) A-I      3'UTR chr11:9771732(+) A-I      3'UTR chr11:9771698(+) A-I      3'UTR chr11:9771816(+) A-I      3'UTR chr11:9771767(+) A-I      3'UTR chr11:9771768(+) A-I      3'UTR chr11:9771843(+) A-I      3'UTR chr11:9771890(+) A-I      3'UTR chr11:9740398(+) A-I      intronic chr11:9693962(+) A-I      intronic chr11:9724230(+) A-I      intronic chr11:9712005(+) A-I      intronic chr11:9740586(+) A-I      intronic chr11:9766438(+) A-I      intronic chr11:9747356(+) A-I      intronic chr11:9763984(+) A-I      intronic chr11:9691473(+) A-I      intronic chr11:9694142(+) A-I      intronic chr11:9704973(+) A-I      intronic chr11:9696395(+) A-I      intronic chr11:9712630(+) A-I      intronic chr11:9742463(+) A-I      intronic chr11:9748680(+) A-I      intronic chr11:9718959(+) A-I      intronic chr11:9721147(+) A-I      intronic chr11:9722819(+) A-I      intronic chr11:9721251(+) A-I      intronic chr11:9734063(+) A-I      intronic chr11:9740952(+) A-I      intronic chr11:9740775(+) A-I      intronic chr11:9696082(+) A-I      intronic chr11:9740399(+) A-I      intronic chr11:9704814(+) A-I      intronic chr11:9726123(+) A-I      intronic chr11:9740877(+) A-I      intronic chr11:9719064(+) A-I      intronic chr11:9691514(+) A-I      intronic chr11:9704692(+) A-I      intronic chr11:9763541(+) A-I      intronic chr11:9724061(+) A-I      intronic chr11:9691515(+) A-I      intronic chr11:9717491(+) A-I      intronic chr11:9732509(+) A-I      intronic chr11:9704883(+) A-I      intronic chr11:9719347(+) A-I      intronic chr11:9721253(+) A-I      intronic chr11:9748749(+) A-I      intronic chr11:9722813(+) A-I      intronic chr11:9717443(+) A-I      intronic chr11:9687726(+) A-I      intronic chr11:9691554(+) A-I      intronic chr11:9731256(+) A-I      intronic chr11:9695503(+) A-I      intronic chr11:9724477(+) A-I      intronic chr11:9734013(+) A-I      intronic chr11:9724058(+) A-I      intronic chr11:9704404(+) A-I      intronic chr11:9748814(+) A-I      intronic chr11:9732669(+) A-I      intronic chr11:9740926(+) A-I      intronic chr11:9690879(+) A-I      intronic chr11:9688494(+) A-I      intronic chr11:9734025(+) A-I      intronic chr11:9724516(+) A-I      intronic chr11:9732703(+) A-I      intronic chr11:9696369(+) A-I      intronic chr11:9734031(+) A-I      intronic chr11:9695628(+) A-I      intronic chr11:9740690(+) A-I      intronic chr11:9732697(+) A-I      intronic chr11:9695473(+) A-I      intronic chr11:9691544(+) A-I      intronic chr11:9712604(+) A-I      intronic chr11:9691524(+) A-I      intronic chr11:9734080(+) A-I      intronic chr11:9721220(+) A-I      intronic chr11:9747258(+) A-I      intronic chr11:9763983(+) A-I      intronic chr11:9747348(+) A-I      intronic chr11:9726120(+) A-I      intronic chr11:9704798(+) A-I      intronic chr11:9718506(+) A-I      intronic chr11:9696468(+) A-I      intronic chr11:9759189(+) A-I      intronic chr11:9704888(+) A-I      intronic chr11:9719465(+) A-I      intronic chr11:9734506(+) A-I      intronic chr11:9716721(+) A-I      intronic chr11:9704446(+) A-I      intronic chr11:9712545(+) A-I      intronic chr11:9742543(+) A-I      intronic chr11:9766344(+) A-I      intronic chr11:9740497(+) A-I      intronic chr11:9696612(+) A-I      intronic chr11:9704365(+) A-I      intronic chr11:9696018(+) A-I      intronic chr11:9704324(+) A-I      intronic chr11:9704411(+) A-I      intronic chr11:9712606(+) A-I      intronic chr11:9740825(+) A-I      intronic chr11:9695657(+) A-I      intronic chr11:9718934(+) A-I      intronic chr11:9691580(+) A-I      intronic chr11:9696100(+) A-I      intronic chr11:9712004(+) A-I      intronic chr11:9696106(+) A-I      intronic chr11:9716762(+) A-I      intronic chr11:9721249(+) A-I      intronic chr11:9695559(+) A-I      intronic chr11:9764067(+) A-I      intronic chr11:9716665(+) A-I      intronic chr11:9718577(+) A-I      intronic chr11:9747299(+) A-I      intronic chr11:9691499(+) A-I      intronic chr11:9771777(+) A-I      3'UTR chr11:9771709(+) A-I      3'UTR chr11:9771699(+) A-I      3'UTR chr11:9771741(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SWAP70	chr11:9720731(+) A-I intron -    21960545 chr11:9724058(+) A-I intron -    21960545 chr11:9724059(+) A-I intron -    21960545 chr11:9724477(+) A-G intron -    22484847 chr11:9724516(+) A-G intron -    22484847 chr11:9734080(+) A-G intron -    22484847 chr11:9696100(+) A-G intron -    22484847 chr11:9718531(+) A-G intron -    22484847 chr11:9740536(+) A-G intron -    22484847 chr11:9763536(+) A-G intron -    22484847 chr11:9763983(+) A-G intron -    22484847 chr11:9763984(+) A-G intron -    22484847 chr11:9771698(+) A-G intron -    22484847 chr11:9771732(+) A-G intron -    22484847 chr11:9771767(+) A-G intron -    22484847 chr11:9771768(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SWAP70	chr11:9746260-9746261(+) m6A 3'UTR//CDS//exon       22608085 chr11:9746269-9746270(+) m6A 3'UTR//CDS//exon       24981863//26404942//22608085 chr11:9746320-9746321(+) m6A 3'UTR//CDS//exon       24981863//26404942//22608085 chr11:9746344-9746345(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22608085 chr11:9746364-9746365(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22608085 chr11:9746372-9746373(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22608085 chr11:9746407-9746408(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22608085 chr11:9754151-9754152(+) m6A 3'UTR//CDS//exon       24981863 chr11:9754175-9754176(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9754184-9754185(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9754205-9754206(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9759761-9759762(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9759813-9759814(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9759824-9759825(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761732-9761733(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761747-9761748(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761771-9761772(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761777-9761778(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761809-9761810(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761849-9761850(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761871-9761872(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761913-9761914(+) m6A exon//intron       24284625//24209618//24981863 chr11:9762039-9762040(+) m6A exon//intron       25456834//24981863 chr11:9762048-9762049(+) m6A exon//intron       25456834//24981863 chr11:9762093-9762094(+) m6A exon//intron       25456834 chr11:9763436-9763437(+) m6A exon//intron       - chr11:9763474-9763475(+) m6A exon//intron       24209618//24981863 chr11:9769437-9769438(+) m6A CDS//intron       24209618//24981863//22575960 chr11:9769477-9769478(+) m6A CDS//intron       24284625//24209618//24981863//22575960 chr11:9769527-9769528(+) m6A CDS//intron       24284625//24209618//24981863//22575960 chr11:9769571-9769572(+) Tm CDS//intron       - chr11:9770669-9770670(+) m6A CDS//intron       24284625//24209618//24981863//27773535 chr11:9770685-9770686(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr11:9770725-9770726(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr11:9771419-9771420(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr11:9771444-9771445(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr11:9771468-9771469(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr11:9771488-9771489(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:9771505-9771506(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:9771582-9771583(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:9771591-9771592(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:9771708-9771709(+) m6A 3'UTR//intron       24981863 chr11:9771877-9771878(+) m6A 3'UTR       24284625//24981863 chr11:9771890-9771891(+) m6A 3'UTR       24284625//24981863 chr11:9771895-9771896(+) m6A 3'UTR       24284625//24981863 chr11:9771900-9771901(+) m6A 3'UTR       24284625//24981863 chr11:9771905-9771906(+) m6A 3'UTR       24284625//24981863 chr11:9771910-9771911(+) m6A 3'UTR       24284625//24981863 chr11:9771918-9771919(+) m6A 3'UTR       24284625//24981863 chr11:9772209-9772210(+) m6A 3'UTR       24981863 chr11:9772268-9772269(+) m6A 3'UTR       24981863 chr11:9772999-9773000(+) m6A 3'UTR       26404942 chr11:9773857-9773858(+) m6A 3'UTR       24284625 chr11:9773894-9773895(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374b-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Human mast cell line (HMC-1)     24009880 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Neural progenitor cells     21363885
	SWAP70	Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-374b-5p	Sensorad 99342 Drug sensitive Pyrazolo[1,5-b]pyridazine deriv. 40 6539382 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive Antibiotic 1907-VIII 5477807 Drug sensitive Artelasticin 5471311 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive 8-Hydroxymanzamine A 5270765 Drug sensitive Trichopolyn 431962 Drug sensitive Rogiolol 402519 Drug sensitive 2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive 7-Chloro-1-methyl-phenothiazone 369386 Drug sensitive 6-(5-Tetrahydropyranylossi-1-pentynyl)-2(2H)-pyranone 24203140 Drug sensitive Victoria Blue R 16599 Drug sensitive Butyltriphenylphosphonium bromide 159628 Drug sensitive Triethyltin chloride 13820 Drug sensitive 12-Iminodaunorubicin hcl 135539784 Drug sensitive 1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive leucinostatine d - Drug sensitive streptorubrin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-374b-5p	Gemcitabine 60750 Drug interaction    RC00007458 D-Glucose 5793 Drug interaction    RC00007457 Cholecalciferol 5280795 Drug interaction    RC00007461 Docosahexaenoic acid 445580 Drug interaction    RC00007459 5-Fluorouracil 3385 Drug interaction    RC00007456 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007455 Tamoxifen 2733526 Drug interaction    RC00007460 Marine fungal metabolite 1386A - Drug interaction    RC00007462

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374b-5p
Interactor2: SWAP70

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.