Basic Information:

  VIRBase ID:  

HHID00068003

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-5p:  MIMAT0004955          TXNRD1:  NM_003330     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374b-5p	TXNRD1
miRBase Accession/Entrez ID	MIMAT0004955	7296
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GRIM-12//TR//TR1//TRXR1//TXNR

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TXNRD1	chr12:104690287(+) A-I      intronic chr12:104690872(+) A-I      intronic chr12:104692340(+) A-I      intronic chr12:104740025(+) A-I      intronic chr12:104731388(+) A-I      intronic chr12:104731385(+) A-I      intronic chr12:104731380(+) A-I      intronic chr12:104740782(+) A-I      intronic chr12:104739865(+) A-I      3'UTR chr12:104739877(+) A-I      3'UTR chr12:104731371(+) A-I      intronic chr12:104692381(+) A-I      intronic chr12:104711760(+) A-I      intronic chr12:104711757(+) A-I      intronic chr12:104621466(+) A-I      intronic chr12:104612854(+) A-I      intronic chr12:104711732(+) A-I      intronic chr12:104711693(+) A-I      intronic chr12:104739890(+) A-I      3'UTR chr12:104694586(+) A-I      intronic chr12:104692343(+) A-I      intronic chr12:104692342(+) A-I      intronic chr12:104692331(+) A-I      intronic chr12:104685451(+) A-I      intronic chr12:104685462(+) A-I      intronic chr12:104685442(+) A-I      intronic chr12:104685428(+) A-I      intronic chr12:104686236(+) A-I      intronic chr12:104687295(+) A-I      intronic chr12:104693402(+) A-I      intronic chr12:104740784(+) A-I      intronic chr12:104740785(+) A-I      intronic chr12:104676727(+) A-I      ncRNA chr12:104740013(+) A-I      intronic chr12:104740012(+) A-I      intronic chr12:104740011(+) A-I      intronic chr12:104654134(+) A-I      intronic chr12:104732756(+) A-I      intronic chr12:104684208(+) A-I      intronic chr12:104732755(+) A-I      intronic chr12:104732737(+) A-I      intronic chr12:104724464(+) A-I      intronic chr12:104732702(+) A-I      intronic chr12:104731379(+) A-I      intronic chr12:104732693(+) A-I      intronic chr12:104732670(+) A-I      intronic chr12:104732556(+) A-I      intronic chr12:104732341(+) A-I      intronic chr12:104732287(+) A-I      intronic chr12:104628310(+) A-I      intronic chr12:104731706(+) A-I      intronic chr12:104731682(+) A-I      intronic chr12:104726447(+) A-I      intronic chr12:104731665(+) A-I      intronic chr12:104726433(+) A-I      intronic chr12:104726424(+) A-I      intronic chr12:104724571(+) A-I      intronic chr12:104691403(+) A-I      intronic chr12:104690896(+) A-I      intronic chr12:104667156(+) A-I      intronic chr12:104724563(+) A-I      intronic chr12:104724445(+) A-I      intronic chr12:104723413(+) A-I      intronic chr12:104723226(+) A-I      intronic chr12:104723167(+) A-I      intronic chr12:104722443(+) A-I      intronic chr12:104711654(+) A-I      intronic chr12:104688496(+) A-I      intronic chr12:104710285(+) A-I      intronic chr12:104710272(+) A-I      intronic chr12:104710269(+) A-I      intronic chr12:104704162(+) A-I      intronic chr12:104704069(+) A-I      intronic chr12:104704067(+) A-I      intronic chr12:104704057(+) A-I      intronic chr12:104694626(+) A-I      intronic chr12:104693434(+) A-I      intronic chr12:104693424(+) A-I      intronic chr12:104693269(+) A-I      intronic chr12:104691426(+) A-I      intronic chr12:104691377(+) A-I      intronic chr12:104691333(+) A-I      intronic chr12:104691323(+) A-I      intronic chr12:104691280(+) A-I      intronic chr12:104691053(+) A-I      intronic chr12:104690976(+) A-I      intronic chr12:104690963(+) A-I      intronic chr12:104690832(+) A-I      intronic chr12:104690827(+) A-I      intronic chr12:104690826(+) A-I      intronic chr12:104614934(+) A-I      intronic chr12:104687346(+) A-I      intronic chr12:104686420(+) A-I      intronic chr12:104686241(+) A-I      intronic chr12:104686228(+) A-I      intronic chr12:104685427(+) A-I      intronic chr12:104723250(+) A-I      intronic chr12:104685162(+) A-I      intronic chr12:104685153(+) A-I      intronic chr12:104732211(+) A-I      intronic chr12:104685072(+) A-I      intronic chr12:104684357(+) A-I      intronic chr12:104684241(+) A-I      intronic chr12:104723318(+) A-I      intronic chr12:104684220(+) A-I      intronic chr12:104683681(+) A-I      intronic chr12:104683628(+) A-I      intronic chr12:104688523(+) A-I      intronic chr12:104683610(+) A-I      intronic chr12:104677110(+) A-I      intronic chr12:104702916(+) A-I      intronic chr12:104671807(+) A-I      intronic chr12:104665235(+) A-I      intronic chr12:104665217(+) A-I      intronic chr12:104711759(+) A-I      intronic chr12:104665154(+) A-I      intronic chr12:104663675(+) A-I      intronic chr12:104653951(+) A-I      intronic chr12:104731826(+) A-I      intronic chr12:104650539(+) A-I      intronic chr12:104650538(+) A-I      intronic chr12:104648633(+) A-I      intronic chr12:104648621(+) A-I      intronic chr12:104648337(+) A-I      intronic chr12:104647668(+) A-I      intronic chr12:104643620(+) A-I      intronic chr12:104732420(+) A-I      intronic chr12:104640095(+) A-I      intronic chr12:104640085(+) A-I      intronic chr12:104635093(+) A-I      intronic chr12:104635086(+) A-I      intronic chr12:104690841(+) A-I      intronic chr12:104666689(+) A-I      intronic chr12:104619899(+) A-I      intronic chr12:104628173(+) A-I      intronic chr12:104621819(+) A-I      intronic chr12:104621307(+) A-I      intronic chr12:104692275(+) A-I      intronic chr12:104621280(+) A-I      intronic chr12:104612497(+) A-I      intronic chr12:104612481(+) A-I      intronic chr12:104740000(+) A-I      intronic chr12:104724395(+) A-I      intronic chr12:104732559(+) A-I      intronic chr12:104684309(+) A-I      intronic chr12:104692454(+) A-I      intronic chr12:104692248(+) A-I      intronic chr12:104645721(+) A-I      intronic chr12:104723339(+) A-I      intronic chr12:104650508(+) A-I      intronic chr12:104693486(+) A-I      intronic chr12:104690972(+) A-I      intronic chr12:104691326(+) A-I      intronic chr12:104631642(+) A-I      intronic chr12:104690286(+) A-I      intronic chr12:104722416(+) A-I      intronic chr12:104732701(+) A-I      intronic chr12:104740823(+) A-I      intronic chr12:104740822(+) A-I      intronic chr12:104740798(+) A-I      intronic chr12:104740794(+) A-I      intronic chr12:104740779(+) A-I      intronic chr12:104740623(+) A-I      intronic chr12:104740029(+) A-I      intronic chr12:104739891(+) A-I      3'UTR chr12:104739885(+) A-I      3'UTR chr12:104739908(+) A-I      3'UTR chr12:104684796(+) A-I      NonSyn:Arg->Gly chr12:104676689(+) A-I      ncRNA chr12:104739814(+) A-I      NonSyn:Stp->Trp chr12:104642283(+) A-I      intronic chr12:104740762(+) A-I      intronic chr12:104731419(+) A-I      intronic chr12:104699811(+) A-I      intronic chr12:104694564(+) A-I      intronic chr12:104711437(+) A-I      intronic chr12:104690290(+) A-I      intronic chr12:104684264(+) A-I      intronic chr12:104639128(+) A-I      intronic chr12:104719441(+) A-I      intronic chr12:104667172(+) A-I      intronic chr12:104661092(+) A-I      intronic chr12:104693425(+) A-I      intronic chr12:104690936(+) A-I      intronic chr12:104684215(+) A-I      intronic chr12:104693451(+) A-I      intronic chr12:104711662(+) A-I      intronic chr12:104614942(+) A-I      intronic chr12:104654031(+) A-I      intronic chr12:104711758(+) A-I      intronic chr12:104685522(+) A-I      intronic chr12:104731704(+) A-I      intronic chr12:104693335(+) A-I      intronic chr12:104692355(+) A-I      intronic chr12:104740617(+) A-I      intronic chr12:104690917(+) A-I      intronic chr12:104711663(+) A-I      intronic chr12:104708795(+) A-I      intronic chr12:104685179(+) A-I      intronic chr12:104661160(+) A-I      intronic chr12:104648813(+) A-I      intronic chr12:104687341(+) A-I      intronic chr12:104623038(+) A-I      intronic chr12:104685452(+) A-I      intronic chr12:104740653(+) A-I      intronic chr12:104737760(+) A-I      intronic chr12:104691003(+) A-I      intronic chr12:104685507(+) A-I      intronic chr12:104731808(+) A-I      intronic chr12:104740752(+) A-I      intronic chr12:104711756(+) A-I      intronic chr12:104740658(+) A-I      intronic chr12:104693441(+) A-I      intronic chr12:104642627(+) A-I      intronic chr12:104691244(+) A-I      intronic chr12:104639125(+) A-I      intronic chr12:104666688(+) A-I      intronic chr12:104691243(+) A-I      intronic chr12:104732427(+) A-I      intronic chr12:104722426(+) A-I      intronic chr12:104690849(+) A-I      intronic chr12:104691395(+) A-I      intronic chr12:104721684(+) A-I      intronic chr12:104691273(+) A-I      intronic chr12:104686435(+) A-I      intronic chr12:104612770(+) A-I      intronic chr12:104628275(+) A-I      intronic chr12:104711436(+) A-I      intronic chr12:104693457(+) A-I      intronic chr12:104688511(+) A-I      intronic chr12:104690898(+) A-I      intronic chr12:104722458(+) A-I      intronic chr12:104687386(+) A-I      intronic chr12:104612496(+) A-I      intronic chr12:104623026(+) A-I      intronic chr12:104621843(+) A-I      intronic chr12:104683611(+) A-I      intronic chr12:104623012(+) A-I      intronic chr12:104648628(+) A-I      intronic chr12:104740644(+) A-I      intronic chr12:104731363(+) A-I      intronic chr12:104635288(+) A-I      intronic chr12:104692382(+) A-I      intronic chr12:104615279(+) A-I      intronic chr12:104685503(+) A-I      intronic chr12:104639108(+) A-I      intronic chr12:104631710(+) A-I      intronic chr12:104645695(+) A-I      intronic chr12:104711539(+) A-I      intronic chr12:104685342(+) A-I      intronic chr12:104691405(+) A-I      intronic chr12:104615262(+) A-I      intronic chr12:104691299(+) A-I      intronic chr12:104722482(+) A-I      intronic chr12:104662182(+) A-I      intronic chr12:104668288(+) A-I      intronic chr12:104740677(+) A-I      intronic chr12:104691247(+) A-I      intronic chr12:104615025(+) A-I      intronic chr12:104621062(+) A-I      intronic chr12:104692375(+) A-I      intronic chr12:104692249(+) A-I      intronic chr12:104690875(+) A-I      intronic chr12:104723173(+) A-I      intronic chr12:104732683(+) A-I      intronic chr12:104740618(+) A-I      intronic chr12:104711376(+) A-I      intronic chr12:104740026(+) A-I      intronic chr12:104654195(+) A-I      intronic chr12:104664809(+) A-I      intronic chr12:104650446(+) A-I      intronic chr12:104693291(+) A-I      intronic chr12:104724640(+) A-I      intronic chr12:104723220(+) A-I      intronic chr12:104690731(+) A-I      intronic chr12:104732286(+) A-I      intronic chr12:104667161(+) A-I      intronic chr12:104723342(+) A-I      intronic chr12:104662783(+) A-I      intronic chr12:104739920(+) A-I      3'UTR chr12:104739860(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TXNRD1	chr12:104688496(+) A-I intron -    21960545 chr12:104691395(+) A-G intron -    22484847 chr12:104692382(+) A-G intron -    22484847 chr12:104693425(+) A-G intron -    22484847 chr12:104718267(+) C-T intron -    22484847 chr12:104718280(+) C-T intron -    22484847 chr12:104718315(+) A-T intron -    22484847 chr12:104684208(+) A-G intron -    22484847 chr12:104684215(+) A-G intron -    22484847 chr12:104687341(+) A-G intron -    22484847 chr12:104688496(+) A-G intron -    22484847 chr12:104688511(+) A-G intron -    22484847 chr12:104688523(+) A-G intron -    22484847 chr12:104690286(+) A-G intron -    22484847 chr12:104690290(+) A-G intron -    22484847 chr12:104690841(+) A-G intron -    22484847 chr12:104690849(+) A-G intron -    22484847 chr12:104690875(+) A-G intron -    22484847 chr12:104690972(+) A-G intron -    22484847 chr12:104691003(+) A-G intron -    22484847 chr12:104691243(+) A-G intron -    22484847 chr12:104691244(+) A-G intron -    22484847 chr12:104691247(+) A-G intron -    22484847 chr12:104691273(+) A-G intron -    22484847 chr12:104691299(+) A-G intron -    22484847 chr12:104691403(+) A-G intron -    22484847 chr12:104691405(+) A-G intron -    22484847 chr12:104692249(+) A-G intron -    22484847 chr12:104692275(+) A-G intron -    22484847 chr12:104692375(+) A-G intron -    22484847 chr12:104693335(+) A-G intron -    22484847 chr12:104704021(+) G-A intron -    22484847 chr12:104711756(+) A-G intron -    22484847 chr12:104711758(+) A-G intron -    22484847 chr12:104711759(+) A-G intron -    22484847 chr12:104718148(+) G-T intron -    22484847 chr12:104719480(+) A-T intron -    22484847 chr12:104724395(+) A-G intron -    22484847 chr12:104724464(+) A-G intron -    22484847 chr12:104731434(+) G-A intron -    22484847 chr12:104731704(+) A-G intron -    22484847 chr12:104732211(+) A-G intron -    22484847 chr12:104732286(+) A-G intron -    22484847 chr12:104732683(+) A-G intron -    22484847 chr12:104732701(+) A-G intron -    22484847 chr12:104739860(+) A-G intron -    22484847 chr12:104740617(+) A-G intron -    22484847 chr12:104740752(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TXNRD1	chr12:104659285-104659286(+) Y intron       26075521 chr12:104680780-104680781(+) m6A 5'UTR//intron       24284625//24981863//26404942 chr12:104680908-104680909(+) m6A 5'UTR//intron       24284625//24981863//26404942//27773535//22575960 chr12:104680913-104680914(+) m6A 5'UTR//intron       24284625//24981863//26404942//27773535//22575960 chr12:104681059-104681060(+) m6A 5'UTR//intron       24981863 chr12:104682755-104682756(+) m6A 5'UTR//CDS//exon//intron       24981863//27773535//22575960 chr12:104682781-104682782(+) m6A 5'UTR//CDS//exon//intron       24981863//27773535//22575960 chr12:104697958-104697959(+) m6A intron       24981863//22575960 chr12:104698034-104698035(+) m6A intron       24981863//22575960//22608085 chr12:104698046-104698047(+) m6A intron       24981863//22575960//22608085 chr12:104698210-104698211(+) m6A intron       25456834//24981863//22575960//22608085 chr12:104698272-104698273(+) m6A intron       25456834//24981863//22575960//22608085 chr12:104698337-104698338(+) m6A intron       25456834//24981863//22575960//22608085 chr12:104698399-104698400(+) m6A intron       24981863//22608085 chr12:104698460-104698461(+) m6A intron       24981863//22608085 chr12:104705084-104705085(+) m6A 5'UTR//CDS//intron       26404942 chr12:104707059-104707060(+) m6A CDS//intron       26404942//22575960 chr12:104707085-104707086(+) m6A CDS//intron       26404942 chr12:104709565-104709566(+) m6A CDS//intron       26404942//27773535 chr12:104709597-104709598(+) m6A CDS//intron       26404942//27773535//22575960 chr12:104709624-104709625(+) m6A CDS//intron       26404942//27773535//22575960 chr12:104709638-104709639(+) m6A CDS//intron       26404942//27773535//22575960 chr12:104709670-104709671(+) m6A CDS//intron       26404942//27773535//22575960 chr12:104712705-104712706(+) m6A CDS//intron       27773535//22575960 chr12:104715020-104715021(+) m6A CDS//intron       26404942//27773535 chr12:104715042-104715043(+) m6A CDS//intron       26404942//27773535 chr12:104715054-104715055(+) m6A CDS//intron       26404942//27773535 chr12:104715075-104715076(+) m6A CDS//intron       24981863//26404942//27773535 chr12:104719119-104719120(+) m6A 5'UTR//CDS       24981863//26404942//27773535 chr12:104719135-104719136(+) m6A 5'UTR//CDS       24981863//26404942//27773535 chr12:104720175-104720176(+) m6A CDS       24981863//26404942//27773535//22575960 chr12:104721322-104721323(+) m6A CDS       24981863//26404942//27773535//22575960 chr12:104727964-104727965(+) m6A exon//intron       26404942 chr12:104728105-104728106(+) m6A CDS//exon       26404942 chr12:104732932-104732933(+) Y CDS//exon       26075521 chr12:104732996-104732997(+) m6A CDS//exon       26404942 chr12:104733016-104733017(+) m6A CDS//exon       26404942 chr12:104739926-104739927(+) m6A 3'UTR//intron       24284625//22575960 chr12:104742225-104742226(+) m6A 3'UTR//exon       24284625//26404942//22575960 chr12:104742232-104742233(+) m6A 3'UTR//exon       24284625//26404942//22575960 chr12:104742401-104742402(+) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22575960//22608085 chr12:104742486-104742487(+) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22575960//22608085 chr12:104742735-104742736(+) m6A 3'UTR       26404942//22575960 chr12:104742756-104742757(+) m6A 3'UTR       26404942//22575960 chr12:104742807-104742808(+) m6A 3'UTR       26404942 chr12:104742973-104742974(+) m6A 3'UTR       26404942 chr12:104742997-104742998(+) m6A 3'UTR       26404942 chr12:104743069-104743070(+) m6A 3'UTR       26404942 chr12:104743155-104743156(+) m6A 3'UTR       26404942 chr12:104743264-104743265(+) m6A 3'UTR       26404942 chr12:104743829-104743830(+) m6A 3'UTR       26404942//27773535 chr12:104743930-104743931(+) m6A 3'UTR       27773535 chr12:104743971-104743972(+) m6A 3'UTR       27773535 chr12:104744019-104744020(+) m6A 3'UTR       27773535 chr12:104744024-104744025(+) m6A 3'UTR       27773535 chr12:104744034-104744035(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374b-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Human mast cell line (HMC-1)     24009880 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Neural progenitor cells     21363885
	TXNRD1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-374b-5p	Sensorad 99342 Drug sensitive Pyrazolo[1,5-b]pyridazine deriv. 40 6539382 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive Antibiotic 1907-VIII 5477807 Drug sensitive Artelasticin 5471311 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive 8-Hydroxymanzamine A 5270765 Drug sensitive Trichopolyn 431962 Drug sensitive Rogiolol 402519 Drug sensitive 2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive 7-Chloro-1-methyl-phenothiazone 369386 Drug sensitive 6-(5-Tetrahydropyranylossi-1-pentynyl)-2(2H)-pyranone 24203140 Drug sensitive Victoria Blue R 16599 Drug sensitive Butyltriphenylphosphonium bromide 159628 Drug sensitive Triethyltin chloride 13820 Drug sensitive 12-Iminodaunorubicin hcl 135539784 Drug sensitive 1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive leucinostatine d - Drug sensitive streptorubrin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-374b-5p	Gemcitabine 60750 Drug interaction    RC00007458 D-Glucose 5793 Drug interaction    RC00007457 Cholecalciferol 5280795 Drug interaction    RC00007461 Docosahexaenoic acid 445580 Drug interaction    RC00007459 5-Fluorouracil 3385 Drug interaction    RC00007456 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007455 Tamoxifen 2733526 Drug interaction    RC00007460 Marine fungal metabolite 1386A - Drug interaction    RC00007462

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374b-5p
Interactor2: TXNRD1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.