Basic Information:

  VIRBase ID:  

HHID00067974

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374b-5p:  MIMAT0004955          DCK:  NM_000788     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374b-5p	DCK
miRBase Accession/Entrez ID	MIMAT0004955	1633
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DCK	chr4:71871471(+) A-I      intronic chr4:71871482(+) A-I      intronic chr4:71871493(+) A-I      intronic chr4:71894224(+) A-I      intronic chr4:71887559(+) A-I      intronic chr4:71883914(+) A-I      intronic chr4:71883913(+) A-I      intronic chr4:71876747(+) A-I      intronic chr4:71871696(+) A-I      intronic chr4:71861812(+) A-I      intronic chr4:71894164(+) A-I      intronic chr4:71887647(+) A-I      intronic chr4:71887598(+) A-I      intronic chr4:71894476(+) A-I      intronic chr4:71894047(+) A-I      intronic chr4:71871439(+) A-I      intronic chr4:71894369(+) A-I      Syn:Gln->Gln chr4:71887491(+) A-I      intronic chr4:71861819(+) A-I      intronic chr4:71861713(+) A-I      intronic chr4:71871366(+) A-I      intronic chr4:71871402(+) A-I      intronic chr4:71894158(+) A-I      intronic chr4:71861042(+) A-I      intronic chr4:71894099(+) A-I      intronic chr4:71894127(+) A-I      intronic chr4:71864561(+) A-I      intronic chr4:71894811(+) A-I      intronic chr4:71894374(+) A-I      NonSyn:His->Arg

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DCK	chr4:71871366(+) A-G intron -    22484847 chr4:71871439(+) A-G intron -    22484847 chr4:71885509(+) A-T intron -    22484847 chr4:71887491(+) A-G intron -    22484847 chr4:71894369(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DCK	chr4:71859283-71859284(+) m6A 5'UTR//intron       24981863 chr4:71859399-71859400(+) m6A 5'UTR//intron       24981863 chr4:71859544-71859545(+) m6A 5'UTR       24284625 chr4:71859606-71859607(+) m6A CDS       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374b-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Human mast cell line (HMC-1)     24009880 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Neural progenitor cells     21363885
	DCK	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-374b-5p	Sensorad 99342 Drug sensitive Pyrazolo[1,5-b]pyridazine deriv. 40 6539382 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive Antibiotic 1907-VIII 5477807 Drug sensitive Artelasticin 5471311 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive 8-Hydroxymanzamine A 5270765 Drug sensitive Trichopolyn 431962 Drug sensitive Rogiolol 402519 Drug sensitive 2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive 7-Chloro-1-methyl-phenothiazone 369386 Drug sensitive 6-(5-Tetrahydropyranylossi-1-pentynyl)-2(2H)-pyranone 24203140 Drug sensitive Victoria Blue R 16599 Drug sensitive Butyltriphenylphosphonium bromide 159628 Drug sensitive Triethyltin chloride 13820 Drug sensitive 12-Iminodaunorubicin hcl 135539784 Drug sensitive 1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive leucinostatine d - Drug sensitive streptorubrin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-374b-5p	Gemcitabine 60750 Drug interaction    RC00007458 D-Glucose 5793 Drug interaction    RC00007457 Cholecalciferol 5280795 Drug interaction    RC00007461 Docosahexaenoic acid 445580 Drug interaction    RC00007459 5-Fluorouracil 3385 Drug interaction    RC00007456 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007455 Tamoxifen 2733526 Drug interaction    RC00007460 Marine fungal metabolite 1386A - Drug interaction    RC00007462

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374b-5p
Interactor2: DCK

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.